Acute kidney injury related to cardiac surgery (CS-AKI) is a serious medical issue that creates significant social and economic challenges globally. Inflammatory responses and disruptions in water and salt balance are important contributors to CS-AKI. Earlier studies indicated that pre-surgery levels of NT-proBNP were a dependable indicator of CS-AKI.
View Article and Find Full Text PDFContaminants capable of crossing the placental barrier (PB) adversely affect female reproduction and fetal development. The rapid identification of PB-permeable contaminants is urgently needed due to the inefficiencies of conventional cell-based transwell assays for the screening of large quantities of chemicals. Herein, we construct a PBScreen server using a multifusion deep learning (DL) model for the accurate and rapid screening of PB-permeable chemicals.
View Article and Find Full Text PDFLight Sci Appl
February 2025
Photodetectors equipped with multi-parameter control hold the potential to deliver exceptional performance in a wide range of scenarios, paving the way for developing novel spin-opto-electronic devices. Nevertheless, the integration of such capabilities within a single device is challenging due to the necessity of harmonizing multiple materials with varying degrees of freedom. In this study, we introduce the van der Waals magnet CrSBr, featuring inherent anisotropy and distinctive spin-electronic coupling, to this realm.
View Article and Find Full Text PDFA reconfigurable holographic metasurface (HM) with multifunctional modulation of radiation and scattering for conformal applications is designed in this paper. Based on optical holography theory, a holographic conformal modulation mechanism is proposed, and the conformal surface impedance distribution of HM is derived. To illustrate this mechanism, the designed conformal reconfigurable HM is used to demonstrate a series of radiation and scattering modulation functions, with its reconfigurable property enabling dynamic beam control.
View Article and Find Full Text PDFBMC Cardiovasc Disord
December 2024
Background: Delayed lead perforation is a rare complication of cardiac implantable electronic device (CIED). Clinical presentations range from completely asymptomatic to pericardial tamponade. Surgical lead extraction is recommended and transvenous lead extraction (TLE) with surgical backup is an alternative method.
View Article and Find Full Text PDFDespite extensive studies on magnetic proximity effects, the fundamental excitonic properties of the 2D semiconductor-magnet heterostructures remain elusive. Here, the presence of localized excitons in MoSe/CrSBr heterostructures is unveiled, represented by a new photoluminescence emission feature, X. Our findings reveal that X originates from excitons confined by intrinsic defects in the CrSBr layer.
View Article and Find Full Text PDFThe hydrolysis phase is recognized as the bottleneck in the anaerobic conversion of food waste. This study firstly investigates an innovative surfactant-enhanced thermal hydrolysis (STH) process, using alkyl polyglucoside (APG), a bio-based surfactant, in combination with improved response surface methodology (RSM) to optimize pretreatment conditions for volatile fatty acids (VFAs) production in anaerobic digestion (AD) of food waste. The synergistic effects of the coupled technology and its impact on acid production were explored, and the contributions of the pretreatment techniques were quantified.
View Article and Find Full Text PDFComposting is a sustainable method for managing livestock manure, but the residual heavy metals and antibiotics in the compost pose can pose environmental risks when applied to land. Although many studies focus on occurrence and risk mitigation of heavy metals and antibiotics in manure compost land application, there is a lack of systematic analysis covering the entire chain from source to process and final disposal. Given this, this article provides a comprehensive review of the sources, migration, fate, risk assessment, and risk reduction of heavy metals and antibiotics contamination in land application of livestock manure compost for the first time.
View Article and Find Full Text PDFDeveloping rechargeable batteries that operate within a wide temperature range and possess high safety has become necessary with increasing demands. Rapid and accurate assessment of the melting points (MPs), boiling points (BPs), and flash points (FPs) of electrolyte molecules is essential for expediting battery development. Herein, we introduce Knowledge-based electrolyte Property prediction Integration (KPI), a knowledge-data dual-driven framework for molecular property prediction of electrolytes.
View Article and Find Full Text PDFSolid-state polymer lithium metal batteries are an important strategy for achieving high safety and high energy density. However, the issue of Li dendrites and inherent inferior interface greatly restricts practical application. Herein, this study introduces tris(2,2,2-trifluoroethyl)phosphate solvent with moderate solvation ability, which can not only complex with Li to promote the in-situ ring-opening polymerization of 1,3-dioxolane (DOL), but also build solvated structure models to explore the effect of different solvation structures in the polymer electrolyte.
View Article and Find Full Text PDFBackground/aims: Although endoscopic resection is an effective treatment of rectal neuroendocrine neoplasms (R-NENs) with low malignant potential, there is no consensus on the most recommended endoscopic method. This study aimed to assess the efficacy and acceptability of different endoscopic treatments for R-NENs with low malignant potential.
Materials And Methods: We searched databases for studies on treatments of R-NENs using endoscopic resection.
The escalating levels of plastic waste and energy crises underscore the urgent need for effective waste-to-energy strategies. This study focused on converting polypropylene wastes into high-value products employing various iron-based catalysts and microwave radiative thermal processing. The Al-Fe catalysts exhibited exceptional performance, achieving a hydrogen utilization efficiency of 97.
View Article and Find Full Text PDFThe unique physical tumor microenvironment (TME) and aberrant immune metabolic status are two obstacles that must be overcome in cancer immunotherapy to improve clinical outcomes. Here, an in situ mechano-immunometabolic therapy involving the injection of a biomimetic hydrogel is presented with sequential release of the anti-fibrotic agent pirfenidone, which softens the stiff extracellular matrix, and small interfering RNA IDO1, which disrupts kynurenine-mediated immunosuppressive metabolic pathways, together with the multi-kinase inhibitor sorafenib, which induces immunogenic cell death. This combination synergistically augmented tumor immunogenicity and induced anti-tumor immunity.
View Article and Find Full Text PDFPatients with refractory immune thrombocytopenia (ITP) frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) present a promising alternative, capitalizing on their low immunogenicity and potent immunomodulatory effects for treating diverse autoimmune disorders. This prospective phase I trial enrolled eighteen eligible patients to explore the safety and efficacy of UC-MSCs in treating refractory ITP.
View Article and Find Full Text PDFThis study investigated the Maillard reaction in Baijiu and the effects of extended aging in the presence of Maillard reaction intermediates (MRIs) on aromatic compounds, particularly focusing on heterocyclic changes. MRIs with different aroma types in Baijiu aged 1-18 years and force-aged for 6 weeks were determined. Results revealed that MRIs in soy sauce aroma-type Baijiu were significantly more abundant than those in other types of Baijiu.
View Article and Find Full Text PDFBackground: Open repair of thoracoabdominal aortic aneurysm (TAAA) was characterized by significant risk of postoperative mortality and morbidity. The aim of this study was to determine the perioperative predictors of early and long-term mortality in patients undergoing open repair of TAAA. Besides, the postoperative outcomes in patients with open repair of TAAA were described.
View Article and Find Full Text PDFA novel porous manganese and nitrogen co-doped biochar (Mn-N@SBC) was synthesized via one-step pyrolysis, utilizing loofah agricultural waste as the precursor and NaHCO as the activator. The behavior of bisphenol A adsorbed on Mn-N@SBC was evaluated using static batch adsorption experiments. Compared to direct manganese-nitrogen co-doping, co-doping based on NaHCO activation significantly increased the specific surface area (231 to 1027 m·g) and adsorption capacity (15 to 351 mg·g).
View Article and Find Full Text PDFBackground: Cancer of unknown primary (CUP) is a very challenging disease, accounting for 2% to 9% of all new cancer cases. This type of tumor is a heterogeneous tumor whose primary site cannot be determined by standard examination. It has the characteristics of early metastasis, strong aggressiveness, and unpredictable mode of metastasis.
View Article and Find Full Text PDFSolid-state distillation is a distinctive process for extracting the baijiu aroma compounds that determine the flavor character of baijiu. In this study, the changes in various chemical properties of the aroma compounds in three classical baijiu fermented grain distillation processes were analyzed. The changes in the aroma compounds in the instantaneous distillates were quantified and correlation analyzes were conducted.
View Article and Find Full Text PDFPurpose: Kidney stone disease (KSD) is a common urological disease, but its pathogenesis remains unclear. In this study, we screened KSD-related hub genes using bioinformatic methods and predicted the related pathways and potential drug targets.
Methods: The GSE75542 and GSE18160 datasets in the Gene Expression Omnibus (GEO) were selected to identify common differentially expressed genes (DEGs).
Long-term storage Baijiu has an appealing sensory property, yet the chemical makeup is rarely reported. This study investigated a 30-year-old Jiangxiangxing (JXX) Baijiu and recognized and measured 69 aroma compounds. 3-Methyl-2,4-nonanedione (2.
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