The cerebellar glucose metabolism in moyamoya vasculopathy and its correlation with neurocognitive performance after cerebral revascularization surgery: a [F]FDG PET study.

Background: The vascular cognitive impairment (VCI) is quite common in moyamoya vasculopathy (MMV). However, the abnormality of cerebellar glucose metabolism in MMV and its relationship with patients' neurocognitive performance were few reported.

Objective: In this study, we aimed to investigate the relationship between neurocognitive performance and cerebellar glucose metabolism.

Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.

Aim: The class I histone deacetylases (HDACs) implicate in microglial heterogenization and neuroinflammation following Intracerebral hemorrhage (ICH). Ferroptosis has also been reported in the ICH model. However, the relationship between HDAC1/2's role in microglial heterogenization and neuronal ferroptosis remains unclear.

Comparative study of UV/HO and UV/PMS processes for treating pulp and paper wastewater.

Pulp and paper wastewater (PPWW) contains numerous refractory and harmful contaminants that require advanced treatment to meet the discharge criteria. This study compared the efficacy of two PPWW treatments: ultraviolet/peroxymonosulfate (UV/PMS) and ultraviolet/HO (UV/HO) working under similar circumstances. The initial pH value, oxidant dosage, UV radiation intensity, and pseudo-first-order constant k were systematically studied in both systems.

Impact of intratumoural CD73 expression on prognosis and therapeutic response in patients with gastric cancer.

Aim: CD73 overexpression has been reported in several malignancies and is considered to be a novel immune checkpoint. However, the role and significance of CD73 in gastric cancer (GC) still remain obscure. We aim to investigate the role of CD73 expression in predicting prognosis, shaping immune contexture and guiding therapeutic strategy in GC.

Intratumoral CXCR5CD8T associates with favorable clinical outcomes and immunogenic contexture in gastric cancer.

Studies that examined an association between CD8T and prognosis in gastric cancer are inconsistent, and a distinct population of CXCR5CD8T associated with better overall survival has been reported among various malignancies. Here, we show that the abundance of intratumoral CXCR5CD8T cells is associated with better overall survival in patients with gastric cancer. Patients with TNM II + III gastric cancer with higher intratumoral CXCR5CD8T cell infiltration are more likely to benefit from adjuvant chemotherapy.

Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patients.

As an adverse survival prognosticator, chemokine (C-X-C motif) ligand 13 (CXCL13) has been studied in several types of malignancies. The secretion and physiological roles of CXCL13 in follicular helper T cells (T) cells have been well described, while the clinical significance of CD8 tumor-infiltrating lymphocytes (TILs)-associated CXCL13 remains unknown. This study aims to investigate the clinical significance of CXCL13CD8 T cells in survival and chemotherapeutic responsiveness prediction in gastric cancer.

Intratumoral Foxp3RORγt T cell infiltration determines poor prognosis and immunoevasive contexture in gastric cancer patients.

Background: Foxp3RORγt T cells possess both characteristics of regulatory T cells and T helper 17 cells and show significant immunoregulatory functions in autoimmune diseases. However, the role and clinical significance of Foxp3RORγt T cells in gastric cancer remains unclear.

Methods: We enrolled 452 gastric cancer tissue microarray samples and 60 fresh tumor tissue samples from Zhongshan Hospital.

Clinical Outcomes and Immune Metrics in Intratumoral Basophil-Enriched Gastric Cancer Patients.

Background: Accumulation of basophils has been reported in several malignancies. In gastric cancer, the relation between tumor-infiltrating basophils and patient overall survival and chemotherapeutic responsiveness still remains obscure.

Objective: We aimed to investigate the postoperative prognostic and predictive significance of basophils to survival outcomes and chemotherapeutic responsiveness in resectable gastric cancer.

Molecular detection of Blastocystis in black bears and sika deer in northern China.

Protists of the Blastocystis genus are distributed worldwide and can infect a range of hosts. However, data concerning Blastocystis infection are limited for sika deer and are not available for black bears. Therefore, in the present study, a total of 312 black bears (Ursus thibetanus) from Heilongjiang Province and 760 sika deer (Cervus nippon) from four different northern Chinese provinces were investigated.

Intratumoral interleukin-9 delineates a distinct immunogenic class of gastric cancer patients with better prognosis and adjuvant chemotherapeutic response.

Interleukin-9 (IL-9) is a T cell cytokine that is associated with inflammation and allergy, but the expression level of IL-9 in gastric cancer and its clinical significance are less well established. Our study aims to uncover the critical role of IL-9 in the progression of gastric cancer. Here, a total of 453 patients with gastric cancer undergoing curative resection were enrolled for immunohistochemical analyses, and Kaplan-Meier analysis was conducted to compare overall survival of patients in different subgroups.

Tumor-infiltrating podoplanin cells in gastric cancer: clinical outcomes and association with immune contexture.

Podoplanin (PDPN) has been proved to have significant immunoregulatory effects in several types of malignancies and is considered to be a novel immune checkpoint molecule. However, the clinical significance of PDPN and its potential influence on immune contexture in gastric cancer remain obscure. Here, we aimed to investigate the clinical outcomes and immunoregulatory role of tumor-infiltrating PDPN cells (tPDPNs) in gastric cancer.

Lymphocyte-activation gene 3 expression associates with poor prognosis and immunoevasive contexture in Epstein-Barr virus-positive and MLH1-defective gastric cancer patients.

Lymphocyte activation gene 3 (LAG-3) is a transmembrane immune checkpoint that facilitates immune escape via suppressing T-cell-mediated anti-tumor immunity. The role of LAG-3 in gastric cancer is little known. Consequently, we assessed the clinical significance of LAG-3 in gastric cancer.

Poor Clinical Outcomes and Immunoevasive Contexture in Intratumoral IL-10-Producing Macrophages Enriched Gastric Cancer Patients.

Objective: To investigate the clinical significance of IL-10+ tumor-associated macrophages (TAMs) in gastric cancer.

Background: Due to the plasticity and diversity of TAMs, it is necessary to phenotypically and functionally classify subsets of TAMs to better understand the critical role of TAMs in cancer progression. TAMs expressing interleukin-10 (IL-10) have been found to facilitate immune evasion in many malignancies, but the role of IL-10+ TAMs in gastric cancer remains obscure.

Meta-analysis of Toxoplasma gondii in pigs intended for human consumption in Mainland China.

Toxoplasma gondii, is one of the most important foodborne zoonotic pathogens, which can infect virtually all warm-blooded animals, including pigs, and causes severe illness in congenitally infected infants and even death in patients with AIDS. Pigs (Sus scrofa) are one of the most important intermediate hosts of T. gondii, and human transmission occurs through consumption of raw or poorly cooked pork.