Publications by authors named "Yuchang Li"

Tick-borne encephalitis virus (TBEV) can cause life-threatening central nervous system infection. Changes in cerebrospinal fluid (CSF) metabolites may reflect critical aspects of host responses and end-organ damage in neuro infection and neuroinflammation. In this study, we applied an untargeted metabolomics screen of CSF samples to investigate the metabolites profile and explore biomarkers for TBEV infection.

View Article and Find Full Text PDF

An MXene material absorbs visible and IR light which makes a MXene-based solar absorber an ideal absorber. Here, we propose a high-absorption broadband absorber based on an array of MXene composite cylinder ring structures. The structure designed in this article fully utilizes the MXene material's large surface area to volume ratio, and in the wavelength range of 300-5000 nm, the average absorption efficiency is as high as 98.

View Article and Find Full Text PDF
Article Synopsis
  • The study looked at a protein called TSPO that helps move cholesterol in mitochondria, and Atriol is a substance that can stop TSPO from binding to cholesterol.
  • Researchers found that Atriol can help improve a liver disease called MASH by fixing mitochondrial function and reducing inflammation.
  • In tests on rats with MASH, Atriol helped reduce fat buildup, inflammation, and other harmful effects, showing it might be a helpful treatment for this liver condition.
View Article and Find Full Text PDF

In this study, we proposed a bifunctional sensor of high sensitivity and slow light based on carbon nanotubes (CNTs). An array of left semicircular ring (LSR), right semicircular ring (RSR), and circular ring (CR) resonators are utilized to form the proposed metamaterial. The proposed structure can achieve double plasmon-induced transparency (PIT) effects under the excitation of a TM-polarization wave.

View Article and Find Full Text PDF

In this paper, we propose a borophene-based grating structure (BBGS) to realize multi-band plasmon-induced absorption. The coupling of two resonance modes excited by upper borophene grating (UBG) and lower borophene grating (LBG) leads to plasmon-induced absorption. The coupled-mode theory (CMT) is utilized to fit the absorption spectrum.

View Article and Find Full Text PDF

The global headlines have been dominated by the sudden and widespread outbreak of monkeypox, a rare and endemic zoonotic disease caused by the monkeypox virus (MPXV). Genomic composition based machine learning (ML) methods have recently shown promise in identifying host adaptability and evolutionary patterns of virus. Our study aimed to analyze the genomic characteristics and evolutionary patterns of MPXV using ML methods.

View Article and Find Full Text PDF

We proposed a triple-band narrowband device based on a metal-insulator-metal (MIM) structure in visible and near-infrared regions. The finite difference time domain (FDTD) simulated results illustrated that the absorber possessed three perfect absorption peaks under TM polarization, and the absorption efficiencies were about 99.76%, 99.

View Article and Find Full Text PDF

Epitranscriptomic RNA modifications can regulate the stability of mRNA and affect cellular and viral RNA functions. The N4-acetylcytidine (ac4C) modification in the RNA viral genome was recently found to promote viral replication; however, the mechanism by which RNA acetylation in the host mRNA regulates viral replication remains unclear. To help elucidate this mechanism, the roles of N-acetyltransferase 10 (NAT10) and ac4C during the infection and replication processes of the alphavirus, Sindbis virus (SINV), were investigated.

View Article and Find Full Text PDF

Translocator protein (TSPO, 18 kDa), previously known as peripheral-type benzodiazepine receptor, is an evolutionarily conserved and tryptophan-rich 169-amino-acid protein located on the outer mitochondrial membrane. TSPO plays a crucial role in various fundamental physiological functions and cellular processes. Its expression is altered in pathological conditions, thus rendering TSPO a potential tool for diagnostic imaging and an appealing therapeutic target.

View Article and Find Full Text PDF

In this paper, we proposed an ultra-broadband and high absorption rate absorber based on Fe materials. The proposed absorber consists of a rectangle pillar, two rings, a SiO film, a GeSbTe(GST) planar cavity, an Fe mirror, and a SiO substrate. The average absorption reaches 98.

View Article and Find Full Text PDF

In this paper, a TM polarization multi-band absorber is achieved in a graphene-Ag asymmetrical grating structure. The proposed absorber can achieve perfect absorption at 1108 nm, 1254 nm, and 1712 nm (the absorption exceeds 98.4% at the three peaks).

View Article and Find Full Text PDF

Influenza A virus (IAV) is a leading cause of human respiratory infections and poses a major public health concern. IAV replication can affect the expression of DNA methyltransferases (DNMTs), and the subsequent changes in DNA methylation regulate gene expression and may lead to abnormal gene transcription and translation, yet the underlying mechanisms of virus-induced epigenetic changes from DNA methylation and its role in virus-host interactions remain elusive. Here in this paper, we showed that DNMT1 expression could be suppressed following the inhibition of miR-142-5p or the PI3K/AKT signaling pathway during IAV infection, resulting in demethylation of the promotor region of the 2'-5'-oligoadenylate synthetase-like (OASL) protein and promotion of its expression in A549 cells.

View Article and Find Full Text PDF

Mitochondrial membrane protein ATAD3A is a member of the AAA-domain-containing ATPases superfamily. It is important for the maintenance of mitochondrial DNA, structure, and function. In recent years, an increasing number of mutations have been identified in patients with neurological symptoms.

View Article and Find Full Text PDF

Swine coronaviruses (CoVs) have been found to cause infection in humans, suggesting that Suiformes might be potential intermediate hosts in CoV transmission from their natural hosts to humans. The present study aims to establish convolutional neural network (CNN) models to predict host adaptation of swine CoVs. Decomposing of each and sequence was performed with dinucleotide composition representation (DCR) and other traits.

View Article and Find Full Text PDF

Human adenovirus 55 (HAdV-55) has recently caused outbreaks of acute respiratory disease (ARD), posing a significant public threat to civilians and military trainees. Efforts to develop antiviral inhibitors and quantify neutralizing antibodies require an experimental system to rapidly monitor viral infections, which can be achieved through the use of a plasmid that can produce an infectious virus. Here, we used a bacteria-mediated recombination approach to construct a full-length infectious cDNA clone, pAd55-FL, containing the whole genome of HadV-55.

View Article and Find Full Text PDF

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a SARS-like coronavirus, continues to produce mounting infections and fatalities all over the world. Recent data point to SARS-CoV-2 viral infections in the human testis. As low testosterone levels are associated with SARS-CoV-2 viral infections in males and human Leydig cells are the main source of testosterone, we hypothesized that SARS-CoV-2 could infect human Leydig cells and impair their function.

View Article and Find Full Text PDF

Background: Direct-acting antivirals (DAAs) for hepatitis C treatment in China became available since 2017. This study expects to generate evidence to inform decision-making in a nationwide scale-up of DAA treatment in China.

Methods: We described the number of standard DAA treatment at both national and provincial levels in China from 2017 to 2021 based on the China Hospital Pharmacy Audit (CHPA) data.

View Article and Find Full Text PDF
Article Synopsis
  • - Two rapid detection methods for monkeypox virus (MPXV) called F-RPA and VF-RPA have been created.
  • - The VF-RPA method is more sensitive, detecting lower viral quantities (8.53 copies/μL) compared to F-RPA (15.32 copies/μL).
  • - Both methods show no interference from other related viruses and are straightforward, suggesting they could be effective for on-site MPXV testing.
View Article and Find Full Text PDF

The mitochondrial translocator protein (18 kDa; TSPO) is a high-affinity cholesterol-binding protein that is an integral component of the cholesterol trafficking scaffold responsible for determining the rate of cholesterol import into the mitochondria for steroid biosynthesis. Previous studies have shown that TSPO declines in aging Leydig cells (LCs) and that its decline is associated with depressed circulating testosterone levels in aging rats. However, TSPO's role in the mechanistic decline in LC function is not fully understood.

View Article and Find Full Text PDF

SARS-CoV-2 variants have posed significant challenges to the hopes of using ancestral strain-based vaccines to address the risk of breakthrough infection by variants. We designed and developed a bivalent vaccine based on SARS-CoV-2 Alpha and Beta variants (named SCTV01C). SCTV01C antigens were stable at 25 C for at least 6 months.

View Article and Find Full Text PDF

During the coronavirus disease 2019 pandemic, we considered the case of a child with developmental language disorder (DLD) who could not go to the hospital on time to receive timely rehabilitation treatment due to disrupted hospital operations. The application of cloud-based rehabilitation platforms has provided significant advantages and convenience for children with DLD in-home remote rehabilitation. Among them, the JingYun Rehab Cloud Platform is the most widely used in mainland China.

View Article and Find Full Text PDF

Background: Viral antigen detection test is the most common method used to detect viruses in the field rapidly. However, due to the low sensitivity, it can only be used as an auxiliary diagnosis method for virus infection. Improving sensitivity is crucial for developing more accurate viral antigen tests.

View Article and Find Full Text PDF

Introduction: As a country that is heavily burdened by hepatitis C, China's successful responses to this public health threat have significant implications for the achievement of the global elimination goal.

Methods: This article reviews China's strategies for prevention, screening, diagnosis, access to direct-acting antiviral agents (DAA) therapy, and patient management of hepatitis C. It also analyses the major challenges and summarizes the valuable successful international experiences that have implications for China to achieve the elimination goal.

View Article and Find Full Text PDF

The COVID-19 pandemic has frequently produced more highly transmissible SARS-CoV-2 variants, such as Omicron, which has produced sublineages. It is a challenge to tell apart high-risk Omicron sublineages and other lineages of SARS-CoV-2 variants. We aimed to build a fine-grained deep learning (DL) model to assess SARS-CoV-2 transmissibility, updating our former coarse-grained model, with the training/validating data of early-stage SARS-CoV-2 variants and based on sequential Spike samples.

View Article and Find Full Text PDF