Publications by authors named "Yuchang Lang"
Atherosclerosis (AS) is a common disease that seriously threatens human health. So far, the pathogenesis of AS has not been fully understood. This project investigates the effects of circARHGAP12 on AS and its regulatory mechanism.
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- This study explores how miR-18a-5p influences the development of pulmonary arterial hypertension (PAH) by examining its role in smooth muscle cell behavior.
- Clinical samples showed that miR-18a-5p is increased in PAH patients and is linked to the over-proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) under low oxygen conditions.
- The findings indicate that miR-18a-5p targets and suppresses Notch2, a protein that, when overexpressed, can counteract the effects of miR-18a-5p, suggesting a significant molecular mechanism in PAH pathology.