Publications by authors named "Yucan Guan"
Background: Diabetes is a multi-factorial disorder and related complications constitute one of the principal causes of global mortality and disability. The role of ferroptosis in diabetes and its complications is intricate and significant. This study endeavors to disclose the role of ferroptosis in the aforementioned diseases from multiple perspectives through multi-omics.
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- * Human umbilical cord mesenchymal stem cells (hUCMSCs) have shown promise in treating DN by improving kidney structure and function, while also reducing cell death caused by ferroptosis.
- * The study reveals that hUCMSCs inhibit ferroptosis through mechanisms that involve affecting iron content, reactive oxygen species levels, and specific signaling pathways, particularly the JNK/KEAP1/NRF2 pathway, suggesting a potential new way to combat DN.
Obesity-related glomerulopathy, which is an obesity-triggered kidney damage, has become a significant threat to human health. Several studies have recently highlighted the critical role of inflammation in obesity-related glomerulopathy development. Additionally, excess adipose tissue and adipocytes in patients with obesity produce various inflammatory factors that cause systemic low-grade inflammation with consequent damage to vascular endothelial cells, exacerbating glomerular injury.
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