Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma.

This letter comments on the recently published manuscript by Yu , in which the authors revealed a novel mechanism by which the m6A-modified long noncoding RNA kinesin family member 9-antisense RNA 1 promotes stemness and sorafenib resistance of hepatocellular carcinoma (HCC) through ubiquitin-specific peptidase 1-mediated deubiquitination of oncogene short stature homeobox 2. Given the high mortality rate and poor prognosis of HCC, the findings by Yu open a new avenue for overcoming HCC burden by focusing on kinesin family member 9-antisense RNA 1 and short stature homeobox 2 as prognostic markers and therapeutic targets.

[Research Advances in the Roles of High-Altitude Hypoxic Stress in Hepatocellular Carcinoma].

Hepatocellular carcinoma (HCC), one of the most prevalent malignant tumors causing the highest mortality globally, imposes an especially heavy burden of disease in China. Individuals living in high-altitude areas have a lower incidence of and mortality resulting from HCC compared with those in low-altitude regions do, potentially due to adaptive evolution in responses to hypoxic stress. Notably, high-altitude hypoxic stress is associated with the development and progression of HCC.

Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis.

Purpose: This study aimed to investigate whether tumor-associated lymphatic vessel density (LVD) could predict the survival of patients with hepato-biliary-pancreatic (HBP) cancers after radical resection.

Methods: A systematic search was conducted using PubMed, Embase, and Cochrane Library from the inception to July 31, 2024 for literature that reported the role of LVD in overall survival (OS) and recurrence-free survival (RFS) of patients with HBP cancers after radical resection.

Results: Ten studies with 761 patients were included for the meta-analysis.

Tumor-associated lymphatic vessel density is a reliable biomarker for prognosis of esophageal cancer after radical resection: a systemic review and meta-analysis.

Purpose: To explore whether tumor-associated lymphatic vessel density (LVD) could be a biomarker for the prognosis of patients with esophageal cancer after radical resection.

Methods: A systematic literature search was performed through PubMed, EMBASE, Wanfang Data, and Cochrane Library from the inception of databases until March 19, 2024. The selected studies investigated overall survival (OS) and/or recurrence-free survival (RFS) of patients with esophageal cancer with different levels of LVD after radical resection.

Portal Venous and Hepatic Arterial Coefficients Predict Post-Hepatectomy Overall and Recurrence-Free Survival in Patients with Hepatocellular Carcinoma: A Retrospective Study.

Background: The dominant artery blood supply is a characteristic of hepatocellular carcinoma (HCC). However, it is not known whether the blood supply can predict the post-hepatectomy prognosis of patients with HCC. This retrospective study investigated the prognostic value of the portal venous and arterial blood supply estimated on triphasic liver CT (as a portal venous coefficient, PVC, and hepatic arterial coefficient, HAC, respectively) in patients with HCC following hepatectomy.

Using solid phase adsorption toxin tracking and extended local similarity analysis to monitor lipophilic shellfish toxins in a mussel culture ranch in the Yangtze River Estuary.

Harmful algal blooms (HABs) and their associated phycotoxins are increasing globally, posing great threats to local coastal ecosystems and human health. Nutrients have been carried by the freshwater Yangtze River and have entered the estuary, which was reported to be a biodiversity-rich but HAB-frequent region. Here, in situ solid phase adsorption toxin tracking (SPATT) was used to monitor lipophilic shellfish toxins (LSTs) in seawaters, and extended local similarity analysis (eLSA) was conducted to trace the temporal and special regions of those LSTs in a one-year trail in a mussel culture ranch in the Yangtze River Estuary.

Brucine suppresses proliferation and promotes apoptosis of human cholangiacarcinoma cells via the inhibition of COX2 expression.

The aim of this study was to investigate the anti-tumor efficacy of brucine on intrahepatic cholangiocarcinoma (ICC). ICC QBC939 cells were treated with brucine, cell viability, cell cycle and apoptosis were analyzed using CCK-8 and flow cytometry. The expression of COX-2 and apoptosis related proteins Casp3, Bax and Bcl-2 were detected by Western blot analysis.

Ag Single Atoms Anchored on CeO with Interfacial Oxygen Vacancies for Efficient CO Electroreduction.

Ag single-atom catalysts (SACs) have great potential in selective electrocatalysis of the CO reduction reaction (CORR) to CO, while it is still a challenge to achieve high current density and high atom efficiency simultaneously. Here, we present a new and simple adsorption-reduction method to prepare Ag SACs supported on CeO (Ag/CeO). It is found that Ag single atoms are anchored on CeO through strong metal-support interaction (SMSI), and each Ag atom is accompanied with three interfacial oxygen vacancies.

3D Dirac semimetals-dielectric elliptical fiber supported tunable terahertz hybrid waveguide.

Based on the proposed elliptical dielectric fiber-polyethylene gap-3D Dirac semimetal (DSM) hybrid plasmonic waveguide structure, the tunable propagation characteristics have been systematically investigated in the terahertz region, taking into account the influences of the structural parameters, the modified dielectric fiber, and the 3D DSM Fermi levels. The results show that as the ratio of the elliptical semi-axis along the -direction and the -direction (/) increases, the hybrid mode confinement increases. The real part of the effective mode index and propagation length increase with increasing the refractive index of the elliptical fiber.

Progress on the investigation and monitoring of marine phycotoxins in China.

Marine phycotoxins associated with paralytic shellfish poisoning (PSP), diarrhetic shellfish poisoning (DSP), amnesic shellfish poisoning (ASP), neurotoxic shellfish poisoning (NSP), ciguatera fish poisoning (CFP), tetrodotoxin (TTX), palytoxin (PLTX) and neurotoxin β-N-methylamino-L-alanine (BMAA) have been investigated and routinely monitored along the coast of China. The mouse bioassay for monitoring of marine toxins has been progressively replaced by the enzyme-linked immunosorbent assay (ELISA) and liquid chromatography tandem mass spectrometry (LC-MS/MS), which led to the discovery of many new hydrophilic and lipophilic marine toxins. PSP toxins have been detected in the whole of coastal waters of China, where they are the most serious marine toxins.

Geographical distribution and seasonal variation in paralytic shellfish toxins in the coastal water of the South China Sea.

Paralytic shellfish toxins (PSTs) are a group of the most harmful neurotoxins distributed worldwide. Marine organism samples, including mollusks, crustaceans and fish, collected from 11 sites around the coastal water of the South China Sea, were analyzed in terms of the PST and toxicity via high-performance liquid chromatography. The PST geographical distribution, detectable rate for PST and toxin content all increased slightly from 2006 to 2008 to 2015.

Seasonal variability of Protoceratium reticulatum and yessotoxins in Japanese scallop Patinopecten yessoensis in northern Yellow Sea of China.

This paper reports a toxic strain of Protoceratium reticulatum, its morphology, phylogeny, yessotoxins (YTXs) production and abundance in northern Yellow Sea of China from 2011 to 2015 was investigated. YTXs in hepatopancreas and edible parts of bottom sowing cultured Japanese scallop Patinopecten yessoensis in this sea area were determined weekly for 5 years. Other potential producers of YTXs, Gonyaulax spinifera and Lingulodinium polyedrum, were also investigated.

[Contamination of typical human enteric viruses in economic shellfish along the Chinese coast].

Objective: The objective of this study is to understand the contamination of human enteric viruses in economic shellfish along the Chinese coast, an important issue of ensuring the seafood safety.

Methods: We established the specific, sensitive and high-throughput gene chip technology, to investigate the contamination of economic shellfish by enteric viruses across a large geographical region of China.

Results: The percentage of positive samples for each virus was as follows: Hepatitis A Virus 4.

A Marteilia-like parasite in blue mussels Mytilus edulis in China.

Species of the genus Marteilia (Phylum Paramyxea) are protozoan parasites of marine mollusks. Marteilia spp. have been detected in mollusks from different parts of the world, but the presence of these parasites in China has not been previously reported.

Haplosporidium nelsoni (MSX) in Japanese scallops Patinopecten yessoensis (Jay, 1857) from Dalian along the northern coast of the Yellow Sea, China.

The protozoan parasite Haplosporidium nelsoni (MSX) was identified in Japanese scallops Patinopecten yessoensis (Jay, 1857) from Dalian along the northern coast of the Yellow Sea, China by histopathologic examination, polymerase chain reaction (PCR) amplification, and in situ hybridization (ISH) assay. H. nelsoni plasmodia-like structures were identified in the digestive glands of scallops by histologic examination, but no parasite spores were observed.

[Self-pollution in Ruditapes philippinarum bottom-cultured area of Zhuanghe coast].

By using sediment trap and closed respirator, a year-round in situ investigation was made on the bio-deposition rate, ammonia excretion rate, and phosphate excretion rate in the Ruditapes philippinarum bottom-cultured area of Zhuanghe coast. The three test rates of R. philippinarum all showed obvious seasonal variability, with the bio-deposition rate ranged in 0.

Haplosporidium nelsoni and H. costale in the Pacific oyster Crassostrea gigas from China's coasts.

We examined 220 Pacific oysters Crassostrea gigas obtained from 11 locations along China's coasts for the presence of the 2 protistan parasites Haplosporidium nelsoni (MSX; multinucleated sphere X) and H. costale (SSO; seaside organism). Haplosporidium-like plasmodia were histologically observed in 9 oysters (4.

A 1-year investigation of the parasite Haplosporidium nelsoni (MSX) in the Pacific oyster Crassostrea gigas from Dayaowan Bay, China.

The infection prevalence of the protozoan parasite Haplosporidium nelsoni (MSX) in Pacific oysters (Crassostrea gigas), collected from Dayaowan Bay on the north coast of the Yellow Sea, China, was investigated in 2007. The traditional histological method of diagnosing H. nelsoni infection in oysters was compared to that of polymerase chain reaction (PCR).

[Cyclic imine toxin gymnodimine: a review].

Gymnodimine (GYM), an algal toxin first detected from New Zealand oysters in 1994, is identified as a cyclic imine toxin and produced by Karenia selliformis, with imino nitrogen attached on loop-coil. Imine is the poisonous functional group of the toxin. GYM has a low oral toxicity, but its acute lethal toxicity of intra-peritoneal injection for mice is very high.

[A indirect competitive ELISA to detect domoic acid in seawater and shellfish].

Objective: A competitive enzyme-linked immunosorbent assay (ELISA) was developed for measurent domoic acid (DA) in seawater and shellfish.

Methods: DA was coupled to bovine serum albumin (BSA) and ovalbumin (OVA) by carbodiimide reaction. DA-BSA as immunogen was injected in BALB/c mice.

[Preparation and application of the monoclonal antibody against okadaic acid].

An competitive indirect enzyme-linked immunosorbent assay was developed for measurement of okadaic acid (OA), a marine biotoxin associated with red tide. OA was coupled to BSA and OVA by carbodiimide reaction. OA-BSA as immunogen were injected in BALB/c mice.