Publications by authors named "Yubing Leng"

Retinal diseases are a rising concern as major causes of blindness in an aging society; therapeutic options are limited, and the precise pathogenesis of these diseases remains largely unknown. Intraocular drug delivery and nanomedicines offering targeted, sustained, and controllable delivery are the most challenging and popular topics in ocular drug development and toxicological evaluation. Retinal organoids (ROs) and organoid-on-a-chip (ROoC) are both emerging as promising in-vitro models to faithfully recapitulate human eyes for retinal research in the replacement of experimental animals and primary cells.

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Three-dimensional (3D) extrusion-based bioprinting is the most widely used bioprinting technology to fabricate bionic tissue or organ constructs by combining biomaterial ink and living cells for tissue engineering and regenerative medicine. One critical issue of this technique is the selection of suitable biomaterial ink to simulate extracellular matrix (ECM) that provides mechanical support for cells and regulates their physiological activities. Previous studies have demonstrated that it is an enormous challenge to form and maintain reproducible 3D constructs and eventually achieve the balance among biocompatibility, mechanical properties, and printability.

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Article Synopsis
  • * Recent advances in techniques like in vitro NMJ models (2D and 3D cultures, organ-on-a-chip, and organoids) allow for better study and manipulation of NMJ functions, complemented by methods for functional analysis such as calcium imaging and optogenetic stimulation.
  • * The paper outlines the use of these in vitro NMJ models for disease modeling and drug screening, highlighting future development trends and the challenges that researchers face in this area.
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