Publications by authors named "Yubin Su"

Colorectal cancer (CRC) ranks third in the number of cancers mainly because of the inability to diagnose it at an early stage. The pathogenesis of CRC is complicated, which is the result of the complex interaction of multiple genetic and environmental factors. Currently, one of the main treatments for CRC is chemotherapy.

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  • Total organic carbon (TOC) is an important measure for detecting organic pollutants in water quality monitoring, but traditional methods are often cumbersome and slow.
  • A new TOC measurement technique was developed using catalytic oxidation with urchin-like CoO microspheres and miniaturized optical emission spectrometry, significantly improving efficiency and sensitivity.
  • The new method demonstrated high accuracy and a low detection limit, making it ideal for fast and effective field analysis of TOC with reduced equipment costs and energy use.
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Antibiotic resistance is a major global challenge requiring new treatments and a better understanding of the bacterial resistance mechanisms. In this study, we compared ampicillin-resistant (R-AMP) and gentamicin-resistant (R-GEN) strains with a sensitive strain (ATCC6538) using metabolomics. We identified 109 metabolites; 28 or 31 metabolites in R-AMP or R-GEN differed from those in ATCC6538.

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Bacterial resistance poses a significant threat to both human and animal health. N-acetylcysteine (NAC), which is used as an anti-inflammatory, has been shown to have distinct and contrasting impacts on bacterial resistance. However, the precise mechanism underlying the relationship between NAC and bacterial resistance remains unclear and requires further investigation.

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BCR-ABL1-independent resistance to imatinib has no effective treatment due to its complexity and diversity. We previously reported that the CDH13 oncogene was expressed at low levels in BCR-ABL1-independent resistant CML cell lines. However, its effects on CML resistant cells and mechanisms remain unknown.

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Global bacterial infections are on the rise, and drug resistance to bacteria is gradually rendering existing antibiotics ineffective. Therefore, the discovery of new strategies is urgently needed. Cellular metabolism is a key factor in the regulation of bacterial drug resistance, which cannot be separated from the utilization of energetic substances, suggesting that energetic substances may be associated with bacterial drug resistance.

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been observed to participate in the progression of HCC. In this study, we investigated the expression, function, and phase separation of RNF214 in HCC.

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Background: Lactobacillus plantarum has been found to play a significant role in maintaining the balance of intestinal flora in the human gut. However, it is sensitive to commonly used antibiotics and is often incidentally killed during treatment. We attempted to identify a means to protect L.

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Metabolic reprogramming mediates antibiotic efficacy. However, metabolic adaptation of microbes evolving from antibiotic sensitivity to resistance remains undefined. Therefore, untargeted metabolomics was conducted to unveil relevant metabolic reprogramming and potential intervention targets involved in gentamicin resistance.

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The global surge in multidrug-resistant bacteria owing to antibiotic misuse and overuse poses considerable risks to human and animal health. With existing antibiotics losing their effectiveness and the protracted process of developing new antibiotics, urgent alternatives are imperative to curb disease spread. Notably, improving the bactericidal effect of antibiotics by using non-antibiotic substances has emerged as a viable strategy.

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Colorectal cancer is a common malignant tumor with high mortality, for which chemotherapy resistance is one of the main reasons. The high expression of ABCG2 in the cancer cells and expulsion of anticancer drugs directly cause multidrug resistance (MDR). Therefore, the development of new ABCG2 inhibitors that block the active causes of MDR may provide a strategy for the treatment of colorectal cancer.

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Background: Similar to hypochlorous acid (HClO), hypobromous acid (HBrO) is one of the most notable reactive oxygen species (ROS). Overexpression of HBrO is linked to various diseases causing organ and tissue loss. Due to HBrO's role in the oxidation of micropollutants, real-time monitoring of HBrO in water-based systems is essential.

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  • The study focused on how Phaeodactylum tricornutum reacts to different levels of inorganic selenium, particularly when in combination with fulvic acid.
  • It found that this combination not only boosted the microalgae's uptake and processing of selenium but also led to increased lipid production.
  • Additionally, the research highlighted that this process redirected carbon usage towards lipids and proteins, meeting essential biofuel standards and demonstrating effective selenium removal and conversion into organic forms like SeCys.
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To meet the needs of food safety for simple, rapid, and low-cost analytical methods, a portable device based on a point discharge microplasma optical emission spectrometer (μPD-OES) was combined with machine learning to enable on-site food freshness evaluation and detection of adulteration. The device was integrated with two modular injection units (i.e.

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Glutamate-ammonia ligase (GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation. Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared with adjacent normal tissues, and correlated with N stage and TNM stage, and low GLUL expression predicted poor survival for gastric cancer patients.

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  • Acid-base titration of complex samples has been improved by integrating an automatic method with miniature point discharge optical emission spectrometry (μPD-OES) and CO vapor generation, allowing for more accurate evaluations of environmental pollution.
  • * This new method effectively reduces interference from high color intensity, salinity, and turbidity found in samples like wastewater and soil, making the process more reliable.
  • * The μPD-OES method achieves high sensitivity and accuracy, with a relative standard deviation under 3.0%, while simplifying the titration process and minimizing the need for expensive or high-power instruments.*
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Methicillin-resistant (MRSA) infection severely threatens human health due to high morbidity and mortality; it is urgent to develop novel strategies to tackle this problem. Metabolites belong to antibiotic adjuvants which improve the effect of antibiotics. Despite reports of L-glutamine being applied in antibiotic adjuvant for Gram-negative bacteria, how L-glutamine affects antibiotics against Gram-positive-resistant bacteria is still unclear.

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  • A novel method called solid phase photothermo-induced chemical vapor generation (SP-PT-CVG) is introduced for efficiently detecting mercury in water using direct immersion solid phase microextraction (DI-SPME) and atomic fluorescence spectrometry (AFS).
  • The system utilizes a setup with 20 nano-TiO-coated tungsten fibers to extract mercury from multiple samples simultaneously, boosting extraction speeds to 40 samples per hour.
  • This method enhances analytical performance by reducing matrix interference and eliminating the need for complex derivatization, achieving a low detection limit of 2.3 ng/L for mercury and demonstrating effective recovery rates in certified reference materials and river water samples.
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Background: The issue of methicillin-resistant (MRSA) resistant to many antibiotics and causing serious infectious diseases is a growing healthcare concern.

Purpose: In recent years, exogenous administration of metabolites in combination with antibiotics can re-sensitize resistant bacteria to antibiotics; however, their effects vary, and their underlying mechanism of action remains elusive.

Methods: We assessed the bactericidal effects of the three amino acids in combination with gentamicin in vitro and in vivo.

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Antibiotic overuse and misuse have promoted the emergence and spread of antibiotic-resistant bacteria. Increasing bacterial resistance to antibiotics is a major healthcare problem, necessitating elucidation of antibiotic resistance mechanisms. In this study, we explored the mechanism of gentamicin resistance by comparing the transcriptomes of antibiotic-sensitive and -resistant .

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Dissolved inorganic carbon (DIC) and dissolved organic carbon (DOC) are two important indicators of global carbon cycle. However, there are no portable analyzers available to simultaneously accomplish high-throughput field detection of them in the same sample. Herein, a simple analyzer comprising a dual-mode reactor to accomplish both chemical vapor generation and headspace sampling, and a miniature point discharge optical emission spectrometer (μPD-OES) was developed for simultaneous and high-throughput detection of DIC and DOC in seawater and lake water.

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  • Accurately measuring dissolved sulfide is complicated due to contamination risks during transport and storage, which stresses the need for effective field analysis.
  • A new method using a nozzle electrode point discharge (NEPD) for converting sulfide to sulfur dioxide (SO) is introduced, paired with a low-power gas phase molecular fluorescence spectrometry (GP-MFS) system for detection.
  • The proposed method achieved a low detection limit and confirmed accuracy in various water samples, making it a practical solution for environmental monitoring of dissolved sulfide.
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The mechanism(s) of how bacteria acquire tolerance and then resistance to antibiotics remains poorly understood. Here, we show that glucose abundance decreases progressively as ampicillin-sensitive strains acquire resistance to ampicillin. The mechanism involves that ampicillin initiates this event via targeting promoter and pyruvate dehydrogenase (PDH) to promote glucose transport and inhibit glycolysis, respectively.

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The emergence of antibiotic resistance greatly increases the difficulty of treating bacterial infections. In order to develop effective treatments, the underlying mechanisms of antibiotic resistance must be understood. In this study, Staphylococcus aureus ATCC6538 strain was passaged in medium with and without gentamicin and obtained lab-evolved gentamicin-resistant S.

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Methicillin-resistant (MRSA) has now become a major nosocomial pathogen bacteria and resistant to many antibiotics. Therefore, Development of novel approaches to combat the disease is especially important. The present study aimed to provide a novel approach involving the use of nucleotide-mediated metabolic reprogramming to tackle intractable methicillin-resistant (MRSA) infections.

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