Nuclear magnetic resonance-based metabolomics and risk of pancreatic cancer: a prospective analysis in the UK Biobank.

Background: Plasma metabolite levels in patients with pancreatic cancer (PC) have changed, but the relationship between the altered plasma metabolites and the risk for PC occurrence is not fully clear, as well as the predictive value of the specific metabolites.

Methods: In this study, we obtained the metabolomics data of 243,145 people from the UK Biobank. An extreme gradient boosting (XGBoost) model, least absolute shrinkage and selection operator (Lasso) regression, and covariate-adjusted Cox proportional hazard regression models were used to evaluate the relationship between metabolites and PC risk.

Targeting the ferroptosis pathway: A novel compound, AZD1390, protects the brain after ischemic stroke.

Background: Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. This process has been implicated in various diseases, including ischemic stroke. Ischemic stroke leads to oxidative stress, iron overload, and reactive oxygen species (ROS) accumulation, which collectively may trigger ferroptotic neuronal cell death.

FBXL14 inhibits foam cell formation and atherosclerosis plaque progression by activating the NRF2 signal axis through ubiquitination of DUSP6.

Objectives: Atherosclerosis is characterized by persistent inflammatory condition, leading to various cardiovascular complications. Foam cell formation, resulting from macrophage uptake of oxidized low-density lipoprotein (ox-LDL), contributes significantly to atherosclerosis progression. This study was designed to investigate the involvement of bispecific phosphatase-6 (DUSP6) and its potential regulatory mechanisms in foam cell formation and atherosclerosis.

Associations between triglyceride-glucose related indices and the risk of incident pancreatic cancer: a large-scale prospective cohort study in the UK Biobank.

Background: Triglyceride-Glucose (TyG) index, a novel surrogate marker for insulin resistance, has been linked to the risk of various cancers, such as breast and colorectal cancers. However, the relationship between the TyG index and its related indices with the risk of pancreatic cancer(PC) remains unclear.

Methods: This large-scale, prospective cohort study utilized data from the UK Biobank, involving 428,152 participants who were free of PC at baseline.

'Did I Make the Right Choice': A Qualitative Exploration of Decision Regret Among Family Caregivers After Hospitalising a Patient With Schizophrenia.

Committing a family member with schizophrenia to a psychiatric ward is a coping mechanism often employed under challenging circumstances. This decision entails significant emotional repercussions and ethical dilemmas, potentially undermining the psychological well-being of the family and eroding public trust in mental health services and professionals. This study investigates the experiences of regret among family members after deciding to commit a relative to a locked ward, adhering to the COREQ guidelines.

Prevalence and sociodemographic configurations of anxiety and depression among caregivers of individuals with mental illness: A meta-analysis and qualitative comparative analysis.

Background: Caring for individuals with mental illness involves significant challenges from both the unique symptoms and societal stigma associated with these conditions, often leading to caregiver neglect despite the heightened risk of anxiety and depression among caregivers. This study was designed to quantify the prevalence of anxiety and depression among caregivers and to offer a detailed configurational analysis of their sociodemographic attributes.

Methods: Random-effects meta-analyses were conducted using generalized linear mixed models to calculate the prevalence rates for each study.

Parental neglect and social media addiction of adolescents: The chain mediation effect of basic psychological need and personal growth initiative.

Purpose: This study aimed to explore the relationship between parental neglect and adolescent social media addiction and its underlying mechanism.

Design And Methods: A cross-sectional design was used in this study. A total of 792 middle school students participated.

Parental burnout and parent-child relationship: the role of harsh parenting in couples.

Parental burnout is a prominent topic in current family research, with proven detrimental effects on the well-being of both parents and children. However, the specific mechanism by which parenting burnout impacts the parent-child relationship within families remains unclear. Furthermore, there is limited research exploring whether parenting burnout has a direct impact on the parent-child relationship.

Strong emissions and aerosol formation potential of higher alkanes from diesel vehicles.

Higher alkanes are a major class of intermediate volatile organic compounds (IVOCs) emitted by vehicles, which have been considered as important precursors of secondary organic aerosol (SOA) in urban area. Dynamometer experiments were conducted to characterize emissions from gasoline and diesel vehicles in China. Three types of higher alkanes, namely acyclic, cyclic, and bicyclic alkanes, were explicitly quantified through the novel proton transfer reaction time-of-flight mass spectrometer with NO ionization (NO PTR-ToF-MS) with time response of 1 second.

Genotype Distribution and High-Risk Factors Analysis of Group B Streptococcus in Late-Stage Pregnant Women in the Linyi Region.

To understand the colonization status of Group B Streptococcus (GBS) in the reproductive tract of pregnant women in the Linyi region, the drug resistance, genotype distribution, and molecular epidemiological characteristics of GBS, and to explore the high-risk factors for GBS infection in late-stage pregnant women. A total of 3269 pregnant women at 35-37 weeks of gestation who visited the Obstetrics Department of Linyi Maternal and Child Health Hospital from January 2019 to December 2021 were selected as the study subjects. Vaginal and rectal swabs were collected for GBS culture.

[Experiences of poor recovery after total endoscopic middle ear surgery].

To investigate the occurrence and managements of poor recovery after total endoscopic middle ear surgery. A total of 302 cases（315 ears） who underwent endoscopic middle ear surgery in our hospital from June 2020 to June 2021 were collected. Follow up by means of endoscopy, pure tone hearing threshold, tympanogram was conducted at 1 month, 3 months, 6 months and 1 year after surgery to analyze the incidence, possible causes, treatment strategies and effects of poor results tympanic membrane healing and hearing recovery.

Development of a set of indicators for the quality of chronic pain management in Chinese community-dwelling older adults: a Delphi study.

Background: Standardized and systematic quality assessments of chronic pain management, particularly among older adult populations, are lacking in resource-limited community settings. A specific set of indicators to evaluate the quality of chronic pain management in this population has yet to be developed. Therefore, the present study constructed a set of indicators to assess the quality of chronic pain management in Chinese community-dwelling older adults, providing a standardized reference and guidance for community health centers to manage chronic pain in this population.

From Pills to Practices: Interpretative Phenomenological Analysis of Medication Experience and Self-Management in Schizophrenia.

Schizophrenia, a mental disorder characterized by delayed onset, high relapse rates, and significant disability, ranks among the top 20 contributors to the global burden of disease and poses a substantial public health challenge. Effective self-management is crucial for the recovery of individuals with schizophrenia, with medication experience playing a vital role. However, the underlying mechanisms and logical relationships remain elusive, hindering the development of effective self-management and enhancement strategies from the perspective of medication experience.

Family Resilience in Patients With Schizophrenia: Potential Influencing Factors and Mediating Effect.

Objective: To identify the determinants of family resilience in the recovery of individuals with schizophrenia using Walsh's family resilience framework.

Design: A cross-sectional study.

Methods: In Northeast China, 403 patients diagnosed with schizophrenia were enrolled for this study, assessing family resilience, family communication, social support, illness knowledge, hope and family functioning.

NINJ1 regulates ferroptosis via xCT antiporter interaction and CoA modulation.

Ninjurin-1 (NINJ1), initially identified as a stress-induced protein in neurons, recently emerged as a key mediator of plasma membrane rupture (PMR) during apoptosis, necrosis, and pyroptosis. However, its involvement in ferroptosis is less well elucidated. Here, we demonstrate that NINJ1 also plays a crucial role in ferroptosis, but through a distinct mechanism.

Redox-mediated photocatalysis towards separate hydrogen production and sulfide oxidation.

We present a redox-mediated photocatalysis for separate hydrogen production and sulfide oxidation. The process involves photocatalytic hydrogen production and Fe(CN) oxidation, followed by spontaneous Fe(CN) reduction and sulfide oxidation to valued sulfur. In this approach, Fe(CN) redox mediators were recycled, and the produced sulfur wouldn't interfere with the photocatalytic performance.

Intracellular Generation of Alkyl Radicals Enabled by a Self-Catalytic ATRP Nanoinitiator.

Oxygen-independent alkyl radicals (R) have demonstrated great promise in combating tumor hypoxia. Currently, Azo compounds have been the primary source of R, suffering from external stimuli and decomposition during circulation. Herein, we developed a self-catalytic ATRP nanoinitiator that could generate R via glutathione (GSH) reduction and thus selectively induce apoptosis of tumor cells.

The path of depression in rural children: A fuzzy-set qualitative comparative analysis across multiple provinces in China.

Objectives: This study explores the combinations of conditional variables contributing to depressive symptoms in rural children.

Methods: We analyzed data from 715 children from a rural mental health database, conducting detailed follow-up investigations on 129 children in Zhejiang and Henan provinces. We used fuzzy set Qualitative Comparative Analysis (fsQCA) and regression analysis to identify causal pathways leading to depression.

Effect of photodynamic therapy on peripheral immune system for unresectable cholangiocarcinoma.

Background: Photodynamic therapy (PDT) has been emerging as a promising treatment for unresectable cholangiocarcinoma (CCA). A number of experiments have demonstrated that PDT could enhance antitumor immunity significantly. However, the impact of PDT on peripheral immune system for unresectable CCA remains unclear.

STING-mediated IL-6 Inhibits OATP1B1 Expression via the TCF4 Signaling Pathway in Cholestasis.

Background And Aims: Organic anion-transporting polypeptides (OATPs) play a crucial role in the transport of bile acids and bilirubin. In our previous study, interleukin 6 (IL-6) reduced OATP1B3 levels in cholestatic disease. However, it remains unclear whether IL-6 inhibits OATP1B1 expression in cholestatic diseases.

ExpOmics: a comprehensive web platform empowering biologists with robust multi-omics data analysis capabilities.

Motivation: High-throughput technologies yield a broad spectrum of multi-omics datasets, which offer unparalleled insights into complex biological systems. However, effectively analyzing this diverse array of data presents challenges, considering factors such as species diversity, data types, costs, and limitations of the available tools.

Results: Herein, we present ExpOmics, a comprehensive web platform featuring 7 applications and 4 toolkits, with 28 customizable analysis functions spanning various analyses of differential expression, co-expression, Weighted Gene Co-expression Network Analysis (WGCNA), feature selection, and functional enrichment.

Prevalence of sexual dysfunction in health care workers: a systematic review and meta-analysis.

Introduction: Health care workers represent a substantial demographic whose welfare and work efficiency are crucial to public health and societal well-being. However, the prevalence of sexual dysfunction within this group is often overlooked, despite its significant occurrence.

Objective: To evaluate the worldwide prevalence of sexual dysfunction among health care workers.

Revealing the functional potential of microbial community of activated sludge for treating tuna processing wastewater through metagenomic analysis.

Reports regarding the composition and functions of microorganisms in activated sludge from wastewater treatment plants for treating tuna processing wastewater remains scarce, with prevailing studies focusing on municipal and industrial wastewater. This study delves into the efficiency and biological dynamics of activated sludge from tuna processing wastewater, particularly under conditions of high lipid content, for pollutant removal. Through metagenomic analysis, we dissected the structure of microbial community, and its relevant biological functions as well as pathways of nitrogen and lipid metabolism in activated sludge.