Publications by authors named "Yubin Chen"

Background: Plasma metabolite levels in patients with pancreatic cancer (PC) have changed, but the relationship between the altered plasma metabolites and the risk for PC occurrence is not fully clear, as well as the predictive value of the specific metabolites.

Methods: In this study, we obtained the metabolomics data of 243,145 people from the UK Biobank. An extreme gradient boosting (XGBoost) model, least absolute shrinkage and selection operator (Lasso) regression, and covariate-adjusted Cox proportional hazard regression models were used to evaluate the relationship between metabolites and PC risk.

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Background: Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. This process has been implicated in various diseases, including ischemic stroke. Ischemic stroke leads to oxidative stress, iron overload, and reactive oxygen species (ROS) accumulation, which collectively may trigger ferroptotic neuronal cell death.

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Objectives: Atherosclerosis is characterized by persistent inflammatory condition, leading to various cardiovascular complications. Foam cell formation, resulting from macrophage uptake of oxidized low-density lipoprotein (ox-LDL), contributes significantly to atherosclerosis progression. This study was designed to investigate the involvement of bispecific phosphatase-6 (DUSP6) and its potential regulatory mechanisms in foam cell formation and atherosclerosis.

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Background: Triglyceride-Glucose (TyG) index, a novel surrogate marker for insulin resistance, has been linked to the risk of various cancers, such as breast and colorectal cancers. However, the relationship between the TyG index and its related indices with the risk of pancreatic cancer(PC) remains unclear.

Methods: This large-scale, prospective cohort study utilized data from the UK Biobank, involving 428,152 participants who were free of PC at baseline.

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Committing a family member with schizophrenia to a psychiatric ward is a coping mechanism often employed under challenging circumstances. This decision entails significant emotional repercussions and ethical dilemmas, potentially undermining the psychological well-being of the family and eroding public trust in mental health services and professionals. This study investigates the experiences of regret among family members after deciding to commit a relative to a locked ward, adhering to the COREQ guidelines.

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Background: Caring for individuals with mental illness involves significant challenges from both the unique symptoms and societal stigma associated with these conditions, often leading to caregiver neglect despite the heightened risk of anxiety and depression among caregivers. This study was designed to quantify the prevalence of anxiety and depression among caregivers and to offer a detailed configurational analysis of their sociodemographic attributes.

Methods: Random-effects meta-analyses were conducted using generalized linear mixed models to calculate the prevalence rates for each study.

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Purpose: This study aimed to explore the relationship between parental neglect and adolescent social media addiction and its underlying mechanism.

Design And Methods: A cross-sectional design was used in this study. A total of 792 middle school students participated.

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Parental burnout is a prominent topic in current family research, with proven detrimental effects on the well-being of both parents and children. However, the specific mechanism by which parenting burnout impacts the parent-child relationship within families remains unclear. Furthermore, there is limited research exploring whether parenting burnout has a direct impact on the parent-child relationship.

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Higher alkanes are a major class of intermediate volatile organic compounds (IVOCs) emitted by vehicles, which have been considered as important precursors of secondary organic aerosol (SOA) in urban area. Dynamometer experiments were conducted to characterize emissions from gasoline and diesel vehicles in China. Three types of higher alkanes, namely acyclic, cyclic, and bicyclic alkanes, were explicitly quantified through the novel proton transfer reaction time-of-flight mass spectrometer with NO ionization (NO PTR-ToF-MS) with time response of 1 second.

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To understand the colonization status of Group B Streptococcus (GBS) in the reproductive tract of pregnant women in the Linyi region, the drug resistance, genotype distribution, and molecular epidemiological characteristics of GBS, and to explore the high-risk factors for GBS infection in late-stage pregnant women. A total of 3269 pregnant women at 35-37 weeks of gestation who visited the Obstetrics Department of Linyi Maternal and Child Health Hospital from January 2019 to December 2021 were selected as the study subjects. Vaginal and rectal swabs were collected for GBS culture.

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To investigate the occurrence and managements of poor recovery after total endoscopic middle ear surgery. A total of 302 cases(315 ears) who underwent endoscopic middle ear surgery in our hospital from June 2020 to June 2021 were collected. Follow up by means of endoscopy, pure tone hearing threshold, tympanogram was conducted at 1 month, 3 months, 6 months and 1 year after surgery to analyze the incidence, possible causes, treatment strategies and effects of poor results tympanic membrane healing and hearing recovery.

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Background: Standardized and systematic quality assessments of chronic pain management, particularly among older adult populations, are lacking in resource-limited community settings. A specific set of indicators to evaluate the quality of chronic pain management in this population has yet to be developed. Therefore, the present study constructed a set of indicators to assess the quality of chronic pain management in Chinese community-dwelling older adults, providing a standardized reference and guidance for community health centers to manage chronic pain in this population.

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Schizophrenia, a mental disorder characterized by delayed onset, high relapse rates, and significant disability, ranks among the top 20 contributors to the global burden of disease and poses a substantial public health challenge. Effective self-management is crucial for the recovery of individuals with schizophrenia, with medication experience playing a vital role. However, the underlying mechanisms and logical relationships remain elusive, hindering the development of effective self-management and enhancement strategies from the perspective of medication experience.

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Objective: To identify the determinants of family resilience in the recovery of individuals with schizophrenia using Walsh's family resilience framework.

Design: A cross-sectional study.

Methods: In Northeast China, 403 patients diagnosed with schizophrenia were enrolled for this study, assessing family resilience, family communication, social support, illness knowledge, hope and family functioning.

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Ninjurin-1 (NINJ1), initially identified as a stress-induced protein in neurons, recently emerged as a key mediator of plasma membrane rupture (PMR) during apoptosis, necrosis, and pyroptosis. However, its involvement in ferroptosis is less well elucidated. Here, we demonstrate that NINJ1 also plays a crucial role in ferroptosis, but through a distinct mechanism.

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Article Synopsis
  • - Older adults with schizophrenia encounter specific health challenges related to treatment needs, complex care, and a higher risk of health issues as they age, with a study revealing these experiences from 15 participants averaging 69 years old.
  • - Four main themes identified in the study include: the burden of managing symptoms, feelings of emptiness and agony, social isolation, and the presence of supportive systems that provide hope.
  • - The findings highlight the need for healthcare professionals to focus on better follow-up care, patient engagement, understanding living conditions, and enforcing welfare policies to enhance the mental health and quality of life for these individuals.
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We present a redox-mediated photocatalysis for separate hydrogen production and sulfide oxidation. The process involves photocatalytic hydrogen production and Fe(CN) oxidation, followed by spontaneous Fe(CN) reduction and sulfide oxidation to valued sulfur. In this approach, Fe(CN) redox mediators were recycled, and the produced sulfur wouldn't interfere with the photocatalytic performance.

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Oxygen-independent alkyl radicals (R) have demonstrated great promise in combating tumor hypoxia. Currently, Azo compounds have been the primary source of R, suffering from external stimuli and decomposition during circulation. Herein, we developed a self-catalytic ATRP nanoinitiator that could generate R via glutathione (GSH) reduction and thus selectively induce apoptosis of tumor cells.

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Objectives: This study explores the combinations of conditional variables contributing to depressive symptoms in rural children.

Methods: We analyzed data from 715 children from a rural mental health database, conducting detailed follow-up investigations on 129 children in Zhejiang and Henan provinces. We used fuzzy set Qualitative Comparative Analysis (fsQCA) and regression analysis to identify causal pathways leading to depression.

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Background: Photodynamic therapy (PDT) has been emerging as a promising treatment for unresectable cholangiocarcinoma (CCA). A number of experiments have demonstrated that PDT could enhance antitumor immunity significantly. However, the impact of PDT on peripheral immune system for unresectable CCA remains unclear.

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Background And Aims: Organic anion-transporting polypeptides (OATPs) play a crucial role in the transport of bile acids and bilirubin. In our previous study, interleukin 6 (IL-6) reduced OATP1B3 levels in cholestatic disease. However, it remains unclear whether IL-6 inhibits OATP1B1 expression in cholestatic diseases.

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Motivation: High-throughput technologies yield a broad spectrum of multi-omics datasets, which offer unparalleled insights into complex biological systems. However, effectively analyzing this diverse array of data presents challenges, considering factors such as species diversity, data types, costs, and limitations of the available tools.

Results: Herein, we present ExpOmics, a comprehensive web platform featuring 7 applications and 4 toolkits, with 28 customizable analysis functions spanning various analyses of differential expression, co-expression, Weighted Gene Co-expression Network Analysis (WGCNA), feature selection, and functional enrichment.

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Introduction: Health care workers represent a substantial demographic whose welfare and work efficiency are crucial to public health and societal well-being. However, the prevalence of sexual dysfunction within this group is often overlooked, despite its significant occurrence.

Objective: To evaluate the worldwide prevalence of sexual dysfunction among health care workers.

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Article Synopsis
  • Winter jasmine, a shrub native to China, experienced significant anthracnose symptoms in a public garden in Shenzhen, leading to a disease incidence rate of 65%.
  • In a study, tissue samples were collected, sterilized, and cultured on potato dextrose agar, yielding 32 isolates of Colletotrichum-like fungi.
  • Three isolates were selected for further analysis, showing similar morphological characteristics and high genetic similarity to the known pathogen C. fructicola.
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Reports regarding the composition and functions of microorganisms in activated sludge from wastewater treatment plants for treating tuna processing wastewater remains scarce, with prevailing studies focusing on municipal and industrial wastewater. This study delves into the efficiency and biological dynamics of activated sludge from tuna processing wastewater, particularly under conditions of high lipid content, for pollutant removal. Through metagenomic analysis, we dissected the structure of microbial community, and its relevant biological functions as well as pathways of nitrogen and lipid metabolism in activated sludge.

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