Clickable liposomes for on-demand reversal of antiplatelet drugs: Towards a safe management of bleeding risks associated with antithrombotic therapy.

Antithrombotic drugs are widely used to prevent thrombotic events in patients with cardiovascular diseases. However, they all carry varying degrees of bleeding risk. Currently, there are no approved reversal agents for antiplatelet medications, which limits their further clinical application and poses challenges in managing bleeding complications.

Enteric-coated cerium dioxide nanoparticles for effective inflammatory bowel disease treatment by regulating the redox balance and gut microbiome.

Reactive oxygen species (ROS) play crucial roles in the pathogenesis of inflammatory bowel disease (IBD) by disrupting the mucosal barrier and subsequently leading to the dysregulation of the gut microbiome. Therefore, ROS scavengers present a promising and comprehensive strategy for the effective IBD treatment. In the current work, we explored the therapeutic potential of cerium dioxide (CeO) nano-enzyme, which is well-known for their potent antioxidant properties and capability to mimic natural antioxidant enzymes in the regulation of oxidative stress.

Engineered P2Y-Overexpressing Cell-Membrane-Wrapped Nanoparticles for the Functional Reversal of Ticagrelor and Clopidogrel.

Antiplatelet agents, particularly P2Y receptor inhibitors, are critical medicines in the prevention and treatment of thrombotic diseases in the clinic. However, their long-term use introduces a significant risk of bleeding in patients with cardiovascular diseases. Whether the bleeding is caused by the drug itself or due to surgical procedures or trauma, the need to rapidly reverse the effects of antiplatelet agents in the circulation is essential; however, no such agents are currently available.

An efficient cerium dioxide incorporated nickel cobalt phosphide complex as electrocatalyst for All-pH hydrogen evolution reaction and overall water splitting.

Transition metal phosphides (TMPs) have been considered as potential electrocatalysts with adjustable valence states, metal characteristics, and phase diversity. However, it is necessary but remains a major challenge to obtain efficient and durable TMPs catalysts, which can realize efficiently for not only all-pH hydrogen evolution reaction (HER), but also oxygen evolution reaction (OER). Hence, cerium dioxide incorporated nickel cobalt phosphide growth on nickel foam (CeO/NiCoP) is fabricated by hydrothermal and phosphating reaction.

Atomically dispersed Au anchored on CeOto enhancing the antioxidant activity.

The modification of Au nanoparticles can improve the antioxidant activity of CeO, however, nano Au/CeOhas also met some problems such as low atomic utilization, the limit of reaction conditions, and high cost. Au single atom catalysts can well solve the above-mentioned problems, but there are some contradictory results about the activity of single atom Au/CeOand nano Au/CeO. Here, we synthesized rod-like Au single atom Au/CeO(0.