Publications by authors named "Yubell Alvarez"

Article Synopsis
  • Immune response genes vary widely among humans and mice, leading to different defense responses based on genetic differences, which can complicate research outcomes.
  • This study used RNA sequencing and variant analysis to uncover significant genetic variations in a commonly used mouse model of NLRP3 deficiency, highlighting the impact of the Nlrp1 locus on macrophage activation independently of the NLRP3 status.
  • The research provides a method to identify important genetic variations and evaluate contamination in transgenic mice studies, enhancing the reliability of findings in host defense research.
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Context: The fusion gene BCR-ABL1 is present in at least the fourth part of B-cell acute lymphoblastic leukemia adult cases. Patients with this fusion gene are candidates to tyrosine kinase inhibitors treatment, and the response to this therapy can be measure by quantification of BCR-ABL1 transcripts. Some patients relapse because the presence of mutations in the tyrosine kinase domain of BCR-ABL1.

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Objectives: To evaluate the immunomodulatory effect on lymphocyte subsets, dendritic cells (DC), Th1 / Th2 / Th17 and inflammatory cytokines on systemic level and/or in the tumor microenvironment of mice with or without melanoma.

Materials And Methods: Peripheral blood and/or primary tumors samples were obtained of mice with B16 melanoma treated or not with a hydroalcoholic extract of Uncaria tomentosa (UT) with 5.03% of pentacyclic oxindole alkaloids (UT-POA) obtained from the bark of the plant.

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