Publications by authors named "Yubao Zou"
Purpose: To compare the feasibility and safety of three approaches for bilateral adrenal venous sampling (AVS) and their influence on the outcomes of adrenalectomy for dominant lateral primary aldosteronism (PA).
Methods: 182 PA patients who underwent AVS at Fuwai Hospital between January 2022 and March 2024 were enrolled. According to the puncture access, patients were divided into three groups: simultaneous AVS via antecubital approach group (Group A, N = 48), simultaneous AVS via femoral approach group (Group B, N = 44) and sequential AVS via antecubital approach group (Group C, N = 90).
We conducted a retrospective cohort study to investigate changes in the aldosterone-to-renin ratio (ARR) and other influencing factors in patients with renal artery stenosis (RAS) and primary aldosteronism (PA). Patients with RAS and PA admitted to our hospital between January 2016 and December 2021 were retrospectively selected. Based on the standardized PA screening results, the patients were divided into aldosterone-to-renin ratio-positive and -negative groups.
View Article and Find Full Text PDFArticle Synopsis
- - The study compared the long-term effectiveness and safety of renal denervation through transfemoral access (TFA) and upper extremity access (UEA) in patients with resistant hypertension, analyzing data from 85 patients treated at Fuwai Hospital from 2012 to 2019.
- - Results indicated that TFA had a shorter fluoroscopy time, while both groups had similar procedure times and contrast volumes, with no serious complications reported.
- - Follow-up data showed no significant differences in blood pressure changes, antihypertensive medication use, or renal function between TFA and UEA, though more adverse events were reported in the TFA group without significant difference.
Background: The triglyceride-glucose (TyG) index is a reliable marker of insulin resistance that is involved in the progression of hypertension. This study aimed to evaluate the association of the TyG index with the risk for major cardiovascular events (MACE) in young adult hypertension.
Methods: A total of 2,651 hypertensive patients aged 18-40 years were consecutively enrolled in this study.
The burden and management competency of cardiomyopathies in China: a nationwide survey study.
Lancet Reg Health West Pac
May 2024
Background: The public health burden of cardiomyopathies and competency in their management by health agencies in China are not well understood.
Methods: This study adopted a multi-stage sampling method for hospital selection. In the first stage, nationwide tertiary hospital recruitment was performed.
Juxtaglomerular cell tumors (JGCTs) or reninoma are rare kidney tumors leading to secondary hypertension, and the non-specific clinical manifestations bring about challenges to the diagnosis. This study is to summarize the clinical features, laboratory findings, and treatment of JGCTs. The PubMed, EMBASE database, and manual search were utilized to find all cases, and 158 reports containing 261 patients were identified.
View Article and Find Full Text PDFRole of Biomarkers of Myocardial Injury to Predict Adverse Outcomes in Hypertrophic Cardiomyopathy.
Circ Cardiovasc Qual Outcomes
February 2024
Background: Serum troponins and CK-MB (creatine kinase-MB) are readily detectable and reliable cardiac-specific biomarkers of subclinical myocardial injury. This study explores the roles of cTnI (cardiac troponin I) and CK-MB in hypertrophic cardiomyopathy (HCM).
Methods: This study included 1045 patients with HCM who had baseline cTnI and CK-MB measurements at Fuwai Hospital between 1999 and 2019.
Adrenal Venous Sampling Via an Antecubital Approach in Primary Aldosteronism: A Multicenter Study.
J Clin Endocrinol Metab
December 2023
Context: Adrenal venous sampling (AVS) is considered the gold standard for differentiating unilateral and bilateral forms of primary aldosteronism. Currently, almost all AVS procedures are performed via femoral vein access.
Objective: The aim of this study was to evaluate the success rate and safety of AVS via an antecubital approach.
Purpose: Endovascular data on patients with coexistent renal artery stenosis (RAS) and renal artery aneurysm (RAA) caused by fibromuscular dysplasia (FMD) are scarce, and the outcomes from RAS-specific treatment on RAA remain unclear. This study aimed to evaluate the safety and effectiveness of RAS-specific endovascular management in patients with coexisting RAA caused by FMD.
Materials And Methods: Clinical and endovascular data on 19 patients with coexistent RAS and RAA caused by FMD who underwent RAS-specific endovascular therapy were analyzed prospectively.
Article Synopsis
- The study aimed to compare clinical characteristics and outcomes of hypertrophic cardiomyopathy (HCM) patients with and without hypertension (HT) among 696 participants confirmed by genetic testing.
- HCM patients without HT were generally younger and exhibited distinct health metrics, including lower body mass index and smaller left ventricular dimensions, but faced higher risks of cardiovascular and all-cause death, especially in the non-surgical group.
- The findings suggest that the greater mortality in HCM patients without HT may be linked to differences in medical treatment, as those with HT received more active therapies.
Article Synopsis
- Research shows that essential hypertension (EH) is linked to low-grade inflammation, but the details of immune cell status in the blood of EH patients are not fully understood.
- Analysis of peripheral blood mononuclear cells (PBMCs) using advanced cytometry revealed significant changes in immune cell types in EH patients compared to healthy controls, with certain dendritic cells and memory T cells increased and others, like neutrophils and various monocyte subsets, decreased.
- The study concludes that the differences in immune cell numbers and increased expression of important antigens indicate an imbalanced immune response in individuals with essential hypertension.
Article Synopsis
- The study aimed to analyze the clinical characteristics of renal artery fibromuscular dysplasia (FMD) in Chinese patients and evaluate post-angioplasty hypertension cure rates.
- A total of 245 hypertensive patients with renal artery stenosis from FMD were examined, revealing demographic details like a mean age of 26.9 years and a majority being women or children.
- Results indicated that multifocal FMD showed a significantly higher hypertension cure rate after revascularization compared to focal FMD, emphasizing the differing impacts of these conditions.
Background: Subclavian artery stenosis (SAS) is a peripheral arterial disease of asymptomatic appearance and disastrous consequences. The traditional screening method remains unsatisfactory.
Objective: The study aimed to assess the diagnostic performances of inter-arm systolic pressure difference (IASBPD), derivatives of pulse volume recording (PVR), and their combination in detecting subclavian artery stenosis.
Takayasu arteritis (TA) is a rare disease, which is frequently misdiagnosed or its diagnosis can be missed. This study aimed to analyse the characteristics of four-limb blood pressure (4LBP) and brachial-ankle pulse wave velocity (baPWV) in patients with TA, which could be useful in disease detection. We consecutively enrolled 182 patients with TA at Fuwai Hospital between January 2013 and January 2016.
View Article and Find Full Text PDFUnifocal progressed to multifocal renal artery fibromuscular dysplasia.
Eur Heart J Case Rep
January 2022
Patients with hypertrophic cardiomyopathy (HC) caused by compound variants have severe clinical manifestations, but significant clinical heterogeneity remains. Clinical diversity in these patients may result from different combinations of variants. We analyzed the role of cis-compound variants in a Chinese HC pedigree.
View Article and Find Full Text PDFBackground: Chemokines were seldom investigated in Takayasu arteritis (TA) patients. This study aimed to evaluate the plasma levels of chemokines and their association with disease activity, including C-C chemokine ligand (CCL) 2, CCL3, CCL11, CCL20, C-X-C chemokine ligand (CXCL) 8 and CXCL10.
Methods: Chemokines were measured in 85 TA patients, and 28 age- and gender-matched healthy controls.
Objectives: This study aimed to assess the safety, blood pressure changes, and biochemical responses of superselective adrenal artery embolization (SAAE) in hypertensive patients with idiopathic hyperaldosteronism (IHA).
Background: SAAE is a minimally invasive procedure that has been used to successfully treat aldosterone-producing adenoma. However, its effect for patients with IHA is unevaluated.
Objectives: This study aimed to evaluate the safety and clinical efficacy of external carotid artery (ECA) stenting in patients with ipsilateral internal carotid artery (ICA) occlusion.
Background: In patients with ICA occlusion, severe ipsilateral ECA stenosis may exacerbate pre-existing cerebral ischemia and cognitive impairment. It remains unclear whether ECA stenting to normalize ECA collaterals to the cerebralis alleviates cerebral ischemia and improves cognitive function.
Background The (formin homology 2 domain-containing 3) gene has recently been identified as a causative gene of hypertrophic cardiomyopathy (HCM). However, the pathogenicity of variants remains to be evaluated. This study analyzed the spectrum of variants in a large HCM and control cohort, and explored its correlation with the disease.
View Article and Find Full Text PDFObjective: Elevated levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with heart failure-related death in hypertrophic cardiomyopathy (HCM), but the relationship between NT-proBNP level and sudden cardiac death (SCD) in HCM remains undefined.
Methods: The study prospectively enrolled 977 unrelated patients with HCM with available NT-proBNP results who were prospectively enrolled and followed for 3.0±2.