Programmed Cell Death-Related Gene Signature Associated with Prognosis and Immune Infiltration and the Roles of HMOX1 in the Proliferation and Apoptosis were Investigated in Uveal Melanoma.

Background: Uveal melanoma (UVM) is the most common primary ocular malignancy, with a wide range of symptoms and outcomes. The programmed cell death (PCD) plays an important role in tumor development, diagnosis, and prognosis. There is still no research on the relationship between PCD-related genes and UVM.

HLA-DR genetic polymorphisms and hepatitis B virus mutations affect the risk of hepatocellular carcinoma in Han Chinese population.

Background: Human leucocyte antigen (HLA)-DR plays a crucial role in the immune response against hepatitis B virus (HBV). We aimed to investigate the associations of HLA-DR single nucleotide polymorphisms (SNPs) with the generation of hepatocellular carcinoma (HCC)-related HBV mutations. The effects of HLA-DR SNPs and their interactions with HBV mutations on HCC risks were also determined.

A risk signature of ubiquitin-specific protease family predict the prognosis and therapy of kidney cancer patients.

Ubiquitin-specific proteases (USPs) are closely related to protein fate and cellular processes through various molecular signalling pathways, including DNA damage repair, p53, and transforming growth factor-β (TGF-β) pathways. In recent years, increasing evidence has revealed the pivotal role of ubiquitination in tumorigenesis of KIRC. However, USPs' molecular mechanism and clinical relevance in kidney cancer still need further exploration.

Nanoarchitecture Manipulation by Polycondensation on KCl Crystals toward Crystalline Lamellar Carbon Nitride for Efficient HO Photoproduction.

A lamellar carbon nitride (CN) framework is one of the most promising materials for solar-driven hydrogen peroxide production. The low dielectric constant of the organic CN framework leads to severe recombination of the excitons, and the photon-to-chemical conversion efficiency is thus unsatisfactory. In this work, by polycondensation of the small molecules on the KCl crystal surface, K-incorporated crystalline CN (CNK) frameworks show significantly extended periodicity of the stacking layers and in-plane orderly organized heptazine/triazine units.

Fluorescent Covalent Organic Frameworks: A Promising Material Platform for Explosive Sensing.

Covalent organic frameworks (COFs) are a novel class of porous crystalline organic materials with organic small molecule units connected by strong covalent bonds and extending in two- or three-dimension in an ordered mode. The tunability, porosity, and crystallinity have endowed covalent organic frameworks the capability of multi-faceted functionality. Introduction of fluorophores into their backbones or side-chains creates emissive covalent organic frameworks.

Nanoarchitectonics in the Ionothermal Synthesis for Nucleation of Crystalline Potassium Poly (heptazine imide) Towards an Enhanced Solar-Driven H O Production.

Solar-driven selective oxygen reduction reaction on polymeric carbon nitride framework is one of the most promising approaches toward sustainable H O production. Potassium poly(heptazine imide) (PHI), with regular metal sites in the framework and favorable crystalline structure, is highly active for photocatalytic selective 2e oxygen reduction to produce H O . By introducing NH Cl into the eutectic KCl-LiCl salt mixture, the PHI framework exhibits a remarkable performance for photocatalytic production of H O , for example, a record high H O photo-production rate of 29.

Rapid pollutant degradation by peroxymonosulfate an unusual mediated-electron transfer pathway under spatial-confinement.

Nano-confinement systems offer various extraordinary chemical/physical properties, due to the spatial restriction and the electronic interaction between the confined species and the surrounding medium. They are, therefore, providing rich opportunities for the design of efficient catalytic reaction systems for pollutant removal. Herein, a highly efficient mediated-electron transfer pathway is identified on a spatially-confined zero valent cobalt for abatement of the organic pollutants by PMS.

Mechanistic analysis of multiple processes controlling solar-driven HO synthesis using engineered polymeric carbon nitride.

Solar-driven hydrogen peroxide (HO) production presents unique merits of sustainability and environmental friendliness. Herein, efficient solar-driven HO production through dioxygen reduction is achieved by employing polymeric carbon nitride framework with sodium cyanaminate moiety, affording a HO production rate of 18.7 μmol h mg and an apparent quantum yield of 27.

Efficient Fenton-like Process for Pollutant Removal in Electron-Rich/Poor Reaction Sites Induced by Surface Oxygen Vacancy over Cobalt-Zinc Oxides.

To achieve high efficiency and low consumption for water treatment in the Fenton reaction, we use the surface oxygen vacancies (OVs) as the electron temporary residences to construct a dual-reaction-center (RDC) Fenton-like catalyst with abundant surface electron-rich/poor areas consisting of OV-rich Co-ZnO microparticles (OV-CoZnO MPs). The lattice-doping of Co into ZnO wurtzite results in the formation of OVs with unpaired electrons (electron-rich OVs) and electron-deficient Co sites according to the structural and electronic characterizations. Both experimental and theoretical calculations prove that the electron-rich OVs are responsible for the capture and reduction of HO to generate hydroxyl radicals, which quickly degrades pollutants, while a large amount of pollutants are adsorbed at the electron-deficient Co sites and act as electron donors for the system, accompanied by their own oxidative degradation.

Graphene oxide modified membrane for highly efficient wastewater treatment by dynamic combination of nanofiltration and catalysis.

Stacked graphene oxide (GO) nano-sheets with plentiful nanopores incorporated onto polymeric membrane are promising for water purification. However, maintaining high water permeability without sacrificing separation efficiency remains a challenge. Delamination of the GO layer from the membrane surface is another bottleneck affecting the efficiency of the material.

Hierarchically Active Poly(vinylidene fluoride) Membrane Fabricated by In Situ Generated Zero-Valent Iron for Fouling Reduction.

Sodium hypochlorite (NaClO) solution is a typical cleaning agent for membrane fouling. However, it can damage membrane chemical structures and produce toxic disinfection byproducts, which in turn reduces the membrane performance. This study focuses on the fabrication of active membranes thereby overcoming the limitations of chemical cleaning.

Soluble Myeloid Triggering Receptor Expressed on Myeloid Cell 1 Might Have More Diagnostic Value for Bacterial Ascites than C-reactive Protein.

The timely and accurate diagnosis of ascites is of great significance for early treatment and prognostication. This study explored the value of soluble myeloid triggering receptor expressed on myeloid cell 1 (sTREM-1) and C-reactive protein (CRP) for assessing ascites. A total of 133 patients with ascites who received treatment at the Affiliated Hospital of Taishan Medical University between September 2015 and September 2017 were retrospectively analyzed.

Semirigid Tripodal Ligand Based Uranyl Coordination Polymer Isomers Featuring 2D Honeycomb Nets.

We report five novel uranyl coordination polymers, [(CH)NH]UO(BTPCA) (1), [(CH)NH]UO(BTPCA) (2), [(CH)NH][UO(BTPCA)][UO(BTPCA)]·(HO) (3), [(CH)NH](UO)(BTPCA)·(HO) (4), and [(CH)NH]UO(BTPCA) (5), by the utilization of semirigid ligand 1,1',1″-(benzene-1,3,5-triyl)tripiperidine-4-carboxylic acid (HBTPCA) and uranyl nitrate through solvothermal reactions. Single-crystal X-ray diffraction analysis reveals that the five compounds share a similar structure composition and local coordination mode to the exclusion of disordered water or DMF molecules. Each UO(COO) motif is connected to six neighboring units through three BTPCA ligands, generating an infinite uranyl honeycomb (6, 3) net.

Visible-Light-Irradiated Graphitic Carbon Nitride Photocatalyzed Diels-Alder Reactions with Dioxygen as Sustainable Mediator for Photoinduced Electrons.

Photocatalytic Diels-Alder (D-A) reactions with electron rich olefins are realized by graphitic carbon nitride (g-C N ) under visible-light irradiation and aerobic conditions. This heterogeneous photoredox reaction system is highly efficient, and the apparent quantum yield reaches a remarkable value of 47 % for the model reaction. Dioxygen plays a critical role as electron mediator, which is distinct from the previous reports in the homogeneous Ru complex photoredox system.

New Organic Semiconducting Scaffolds by Supramolecular Preorganization: Dye Intercalation and Dye Oxidation and Reduction.

The assembly of melamine and 2,5-dihydroxy-1,4-benzoquinone results in new "sheet-like" supramolecular crystals that by controlled thermal condensation can be converted to photoactive materials at relativity low temperatures. The condensation temperature alters the materials properties from polymer-like to carbon materials alongside their morphology and elemental ratio. This new method opens the possibility for the synthesis of new organic, photoactive carbon-nitrogen based frameworks at low calcination temperatures with great simplicity.

Amorphous Sb2S3 embedded in graphite: a high-rate, long-life anode material for sodium-ion batteries.

Amorphous Sb2S3 embedded in a conductive graphite matrix is designed for sodium-ion batteries. Owing to the amorphous structure of the active phase and the conductive graphite matrix, the Sb2S3-graphite electrode exhibits a high initial Coulomblic efficiency, a high rate capacity, and stable cycle performance in sodium-ion batteries.

Conjugation of β-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine.

Meningococcal disease is a fatal illness of sudden onset caused by Neisseria meningitides. Meningococcal capsular polysaccharide (CPS) is a major virulence factor that generally does not induce immunological memory. Conjugation with a carrier protein can significantly increase the immunogenicity of CPS and induce immunological memory.

Template-free TiO2 hollow submicrospheres embedded with SnO2 nanobeans as a versatile scattering layer for dye-sensitized solar cells.

Nanobean SnO2-embedded TiO2 hollow submicrospheres are presented as a scattering layer for the first time in dye-sensitized solar cells. This designed mesoporous submicrostructure simultaneously promotes dye adsorption, light harvesting, and electron transport, leading to 28% improvement in the conversion efficiency compared to film-based SnO2.

Template-free synthesis of core-shell TiO2 microspheres covered with high-energy {116}-facet-exposed N-doped nanosheets and enhanced photocatalytic activity under visible light.

Core-shell TiO2 microspheres possess a unique structure and interesting properties, and therefore, they have received much attention. The high-energy facets of TiO2 also are being widely studied for the high photocatalytic activities they are associated with. However, the synthesis of the core-shell structure is difficult to achieve and requires multiple-steps and/or is expensive.

Porous perovskite LaNiO3 nanocubes as cathode catalysts for Li-O2 batteries with low charge potential.

Developing efficient catalyst for oxygen evolution reaction (OER) is essential for rechargeable Li-O2 battery. In our present work, porous LaNiO3 nanocubes were employed as electrocatalyst in Li-O2 battery cell. The as-prepared battery showed excellent charging performance with significantly reduced overpotential (3.

A novel core-shell magnetic nano-sorbent with surface molecularly imprinted polymer coating for the selective solid phase extraction of dimetridazole.

A novel core-shell magnetic nano-sorbent with surface molecularly-imprinted polymer coating was prepared via a sol-gel process. Methyltrimethoxysilane and 3-aminopropyltriethoxysilane were used as functional monomers, tetraethyl orthosilicate as cross-linker, and Al(3+) as dopant to generate Lewis acid sites in the silica matrix for the metal coordinate interactions with the template dimetridazole (DMZ). The ratios of the monomers, the dopant, and the cross-linker, were optimised by a OA9 (3(4)) orthogonal array design.

Uniform Mesoporous Anatase Hollow Spheres: An Unexpectedly Efficient Fabrication Process and Enhanced Performance in Photocatalytic Hydrogen Evolution.

Uniform mesoporous anatase hollow spheres with high crystallinity have been fabricated by an efficient method, in which biocompatible ethanedioic acid acts as the chelating agent during the Ostwald ripening process. The combination of high crystallinity, large surface area, and mesoporosity leads to an excellent photocatalytic activity. In solar water splitting, the hollow spheres exhibit remarkably enhanced photocatalytic performance that is 1.

Visible-light-induced selective photocatalytic aerobic oxidation of amines into imines on TiO2.

Imines are important intermediates for the synthesis of fine chemicals, pharmaceuticals, and agricultural chemicals. Selective oxidation of amines into their corresponding imines with dioxygen is one of the most-fundamental chemical transformations. Herein, we report the oxidation of a series of benzylic amines into their corresponding imines with atmospheric dioxygen as the oxidant on a surface of anatase TiO(2) under visible-light irradiation (λ>420 nm).

[Preparation, spectral analysis and photocatalytic activities of TiO2 films codoped with iron and nitrogen].

Using tetrabutyl titanate as the titanium source, and ammonia and ferric nitrate as the sources of nitrogen and ferrum respectively, iron and nitrogen-codoped nano-TiO2 gelatins were prepared by sol-gel method. The iron and nitrogen-codoped nano-TiO2 complex films were prepared with the obtained gelatins used to coat the surface of cleaned glass slides by several times of dipping-lifting procedure, followed by natural seasoning at room temperature and calcined at 450 degrees C for 3 hours, then the films were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), X-ray photoelectron spectrum (XPS) and ultraviolet-visible diffuse reflectance spectrum (UV-Vis). The XRD spectra o f samples showed that the Fe-TiO(2-x)Nx, filmswere of anatase structure with a few of oxygen atoms in the lattice of anatase TiO2 substituted by nitrogen atoms, resulting in the distortion of crystal lattice.