Publications by authors named "Yuanzhi Jian"
Article Synopsis
- Deoxynivalenol (DON) exposure can lead to endoplasmic reticulum stress, increased mitochondrial reactive oxygen species (ROS), and changes in macrophage behavior, particularly important for children's health.
- In mice modeling human ages 7-12, low-level DON exposure (0.5 μg/kg bw/day) caused significant liver and gut inflammation after 6 weeks.
- The study identifies a mechanism involving the interaction of proteins MAPK7 and AhR, which drives inflammatory reactions and highlights the potential health risks of DON exposure in children.
[Developmental toxicity of Cry1Ab protein in the embryonic stem-cell model].
Beijing Da Xue Xue Bao Yi Xue Ban
April 2024
Objective: To evaluate the developmental toxicity of Cry1Ab protein by studying its effects on cell proliferation and differentiation ability using a developmental toxicity assessment model based on embryonic stem-cell.
Methods: Cry1Ab protein was tested in seven dose groups (31.25, 62.
Article Synopsis
- * The study examined the effects of a buckwheat-oat-pea (BOP) composite flour on diabetic rats induced by a high-fat diet and streptozotocin injection over 10 weeks.
- * Results indicated that BOP improved glucose and lipid metabolism, reduced liver injury, and altered gut microbiota, suggesting its potential as a stable food substitution for managing diabetes.
(1) Objective: This study aimed to examine the prevalence of metabolic syndrome (MetS) in children aged 6−14 years in Beijing, and to determine whether sedentary behavior is a risk factor. (2) Methods: Using a multistage stratified cluster random sampling method, 3460 students were selected for the Nutrition and Health Surveillance in Schoolchildren of Beijing (NHSSB). Data on children’s sedentary behavior time and MetS indicators were collected using the questionnaires, physical measurements, and laboratory tests.
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- The study investigated the impact of genetically modified insect-resistant maize (2A-7) on the growth and development of young rats compared to non-transgenic maize and a standard diet.
- Rats were divided into four diet groups, including two with varying levels of 2A-7 maize, and the health metrics of their offspring were analyzed at weaning.
- Results indicated that the growth, organ health, and overall development of the offspring from the 2A-7 diet were similar to those from the non-transgenic diet, suggesting that 2A-7 maize is safe for developing rats.