Publications by authors named "Yuanzheng Fu"

Background: Standardized training for resident physicians is the primary form of postgraduate medical education, and it plays a pivotal role in healthcare safety and industry stability. Currently, it has garnered significant attention from healthcare institutions.

Methods: By conducting a comprehensive literature review and a Delphi consultation in June 2022 for which 40 experts in clinical medicine, public health, and other related fields in China were invited.

View Article and Find Full Text PDF
Article Synopsis
  • Interleukin 10 (IL-10) is an important anti-inflammatory cytokine that helps manage immune responses and prevent inflammatory diseases, but its production in macrophages is closely regulated.* -
  • TRIM24, a protein that influences immune responses, was found to be downregulated in macrophages stimulated with LPS; its absence led to increased IL-10 expression and protection against endotoxic shock in mice.* -
  • The study highlights TRIM24's role in regulating IL-10 and suggests that targeting TRIM24 could be a promising approach for treating inflammatory conditions.*
View Article and Find Full Text PDF

Background: Organophosphate esters (OPEs) are common endocrine-disrupting chemicals, and OPE exposure may be associated with type 2 diabetes (T2D). However, greater knowledge regarding the biomolecular intermediators underlying the impact of OPEs on T2D in humans are needed to understand biological etiology.

Objectives: We explored the associations between OPE exposure and glycometabolic markers among older Chinese adults 60-69 years of age to elucidate the underlying mechanisms using a multi-omics approach.

View Article and Find Full Text PDF

Background: Imperatorin (IMP) is a secondary metabolite of plants and is the most abundant in Angelica dahurica. Previous studies showed that IMP exhibited anti-inflammatory activity in RAW264.7 cell line.

View Article and Find Full Text PDF

Isocorydine (ICD) is a type of isoquinoline alkaloid originating from , which has been used to relieve spasm, dilate blood vessels, and treat malaria as well as hypoxia in clinic. However, its effect on inflammation and underlying mechanisms remains unclear. The aim of our study was to determine the potential effects and mechanisms of ICD on pro-inflammatory interleukin-6 (IL-6) expression in bone marrow-derived macrophages (BMDMs) and acute lung injury mouse model.

View Article and Find Full Text PDF

Diarrhea is a global public health issue and a leading cause of childhood malnutrition, growth disturbances, and mortality. The spread of diarrhea is closely linked to the knowledge and maintenance of personal hygiene and quality of drinking water and sanitation facilities. However, there are few such investigations and analysis in rural areas of China.

View Article and Find Full Text PDF

To understand the health impact represented by exposure to current atmospheric pollution in China, an environmental health indicators (EHIs) system of atmospheric pollution was established. The EHIs were based on comprehensive consideration of environment, population, economy and diseases associated with atmospheric pollution. An EHIs evaluation system of atmospheric pollution, based on corresponding EHIs data collection and weighting coefficients determined using principal component analysis, was applied to major provinces and regions in China to evaluate the environmental health status.

View Article and Find Full Text PDF