Publications by authors named "Yuanyuan Wang"

Background: Selenium can inhibit cervical cancers, but the specific mechanism of anti-cervical cancer is not fully understood.

Methods: In this study, we investigated the anti-cervical cancer effect of sodium selenite (SS) in vivo and in vitro to reveal the role of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway in terms of the mechanism. In vivo experiments, HeLa cell xenografts were constructed in BALB/c female nude mice, and then intraperitoneally injected with 3 mg/kg sodium selenite (SS) for 14 days.

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Acetylcholinesterase (AChE) and AChE inhibitors play critical roles in the early diagnosis and treatment of Alzheimer's disease (AD). Herein, a fluorescence/colorimetry/smartphone triple-mode sensing platform was constructed for both AChE activity monitoring and AChE inhibitor screening by exploring a Cu (I) compound, CuI (SR) (R = CHCHNH), as a fluorescent probe. In comparison of most other fluorescent probes, CuI (SR) presented exceptional stability against pH, temperature, UV irradiation, redox agents, and metal ions, as well as good recyclability due to its unique chemical structure.

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Background: Disulfidptosis is an emerging form of regulated cell death distinguished by abnormal disulfide stress and the collapse of the actin network. This study was to construct a prognostic model based on disulfidptosis-related lncRNAs (DRLs) to enhance survival prediction and assess their viability as biomarkers for immunotherapy response in neuroblastoma (NB).

Methods: Transcriptomic and clinical data from NB patients were obtained from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) databases.

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Background: Oncolytic virus therapy is a rapidly evolving emerging approach for the medical management of cancer. Talimogene laherparepvec (T-VEC) is the first and only Food and Drug Administration (FDA)-approved oncolytic virus therapy. Considering that exactly how T-VEC works is not known, there is a strong need for a comprehensive pharmacovigilance study to identify safety signals of potential risks with T-VEC.

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Ultrasound imaging with flexible transducers requires the knowledge of shape geometry for effective beamforming, which such geometry is variable and often unknown. The conventional iteration-based shape estimation methods estimate transducer shape with high computational expense. Although deep-learning-based methods are introduced to reduce computation time, their low shape estimation accuracy limits the practical applications.

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Objective: To examine whether low circulating sex steroid concentrations are associated with the incidence of knee and hip replacement for osteoarthritis in community-dwelling older women.

Study Design: This prospective cohort study examined 5535 Australian women recruited into the Aspirin in Reducing Events in the Elderly (ASPREE) trial, aged ≥70 years, not taking medications affecting sex steroid concentrations, and with sex steroid concentrations measured by liquid chromatography-tandem mass spectrometry.

Main Outcome Measures: The incidence of knee and hip replacement for osteoarthritis was determined by hospitalisations for knee and hip surgical procedures where osteoarthritis was recorded as the indication.

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The Lanzhou lily bulbs are often vulnerable to postharvest infections by pathogenic fungi, leading to lily bulb rot. This study investigated the ability of volatile organic compounds (VOCs) produced by Stenotrophomonas geniculata J-0 to control the highly pathogenic fungus Fusarium oxysporum BH-7 in postharvest Lanzhou lily bulbs. VOCs of S.

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Germany experienced extreme drought periods in 2018 and 2022, which significantly affected forests. These drought periods were natural experiments, providing valuable insights into how different tree species respond to drought. The quantification of species-specific drought responses may help to identify the most climate-change-resilient tree species, thereby informing effective forest regeneration strategies.

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Immunotherapy has significantly altered the treatment paradigm of non-small cell lung cancer (NSCLC), but not all patients experience durable benefits. Predictive biomarkers are needed to identify patients who may benefit from immunotherapy. We retrospectively collected tumor tissues from 65 patients with advanced NSCLC before treatment, and performed transcriptomic and genomic analysis.

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As the adaptor protein that determines substrate specificity of the Cul3-SPOP-Rbx1 E3 ligase complex, SPOP is involved in numerous biological processes. However, its physiological connections with adipogenesis and thermogenesis remain poorly understood. In the current study, we report that the conditional knockout of Spop in mice results in substantial changes in protein expression, including the upregulation of a critical factor associated with thermogenesis, UCP1.

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Background And Objective: Cardiopulmonary exercise testing (CPET) serves as an integrative and comprehensive assessment tool for cardiorespiratory fitness. In this paper, we present a novel multi-dimensional multi-modal network (MDMNet) to identify functional limitation of organ systems via CPET, which is of great importance in clinical practice and yet a challenging task due to (1) the intricate intra-variable associations, and (2) the significant inter-individual variability.

Methods: The proposed model has three compelling characteristics.

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The expansion of global aquaculture has brought challenges from emerging pathogens, resulting in disease-related production losses across various regions. Among these pathogens, aquatic circoviruses-small, single-stranded DNA viruses initially detected in barbel ()-have now been identified in multiple aquaculture species. These viruses have been associated with various clinical manifestations in economically important fish, crustacean, and mollusk species, including acute hemorrhage syndrome, which has shown mortality rates up to 95% in controlled laboratory infections of turbot.

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Background: Egg-based inactivated quadrivalent seasonal influenza vaccine (eIIV4), cell culture-based inactivated quadrivalent seasonal influenza vaccine (ccIIV4), and recombinant haemagglutinin (HA)-based quadrivalent seasonal influenza vaccine (RIV4) have been licensed for use in the USA. In this study, we used antigen-specific serum proteomics analysis to assess how the molecular composition and qualities of the serological antibody repertoires differ after seasonal influenza immunisation by each of the three vaccines and how different vaccination platforms affect the HA binding affinity and breadth of the serum antibodies that comprise the polyclonal response.

Methods: In this comparative, prospective, observational cohort study, we included female US health-care personnel (mean age 47·6 years [SD 8]) who received a single dose of RIV4, eIIV4, or ccIIV4 during the 2018-19 influenza season at Baylor Scott & White Health (Temple, TX, USA).

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Objective: To determine the efficacy and safety of combined low-dose rituximab with conventional therapy for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) treatment.

Methods: Total 73 patients with CIDP were enrolled for the retrospective cohort study, and divided into conventional first-line therapy cohort (n = 40) and combined low-dose rituximab (100 mg per infusion) cohort (n = 33). The outcome measures include scores of I-RODS, mRS, INCAT, ONLS, TSS, and COMPASS 31 scale at baseline and regular four visits (4, 16, 28, and 52 weeks), as well as proportion of favorable response and outcome, corticosteroids dosage, and deterioration occurrence during follow-up.

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Background: and purpose: The investigation of functional plasticity and remodeling of the brain in patients with retinal detachment (RD) has gained increasing attention and validation. However, the precise alterations in the topological configuration of dynamic functional networks are still not fully understood. This study aimed to investigate the topological structure of dynamic brain functional networks in RD patients.

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Gliomas are the most common and malignant form of primary brain tumors. Accurate segmentation and measurement from MRI are crucial for diagnosis and treatment. Due to the infiltrative growth pattern of gliomas, their labeling is very difficult.

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Article Synopsis
  • - The study investigated how levels of sex hormone binding globulin (SHBG) relate to fracture risk in older women, focusing on a group of 4,871 women aged 70 and above who weren't on specific medications.
  • - Results showed a positive correlation between higher SHBG levels and increased fracture risk over approximately 3.9 years, with those in the highest SHBG quartile being significantly more at risk compared to the lowest quartile.
  • - Although two genetic variants were found to influence SHBG levels, they did not correlate with fracture risk, indicating that the increased fracture risk associated with SHBG was not due to genetic factors.
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  • The study aimed to assess the effectiveness of combining medroxyprogesterone acetate (MA) and metformin as a fertility-sparing treatment for atypical endometrial hyperplasia (AEH) and early-stage endometrial adenocarcinoma (G1 EAC).
  • It involved 60 patients who were divided into two groups, one receiving only MA and the other receiving MA plus metformin, with both treatments monitored for up to 12 months through regular follow-ups.
  • Results showed similar complete response rates for both treatments, but the combined group had no significant weight gain compared to the group taking MA alone, and it led to favorable changes in certain endometrial biomarkers.
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  • - Allergic diseases, particularly shrimp allergy, are significant health concerns today, with a focus on key allergens like tropomyosin and arginine kinase, and their roles in different immune response reactions, including IgE-mediated hypersensitivity and non-IgE-mediated reactions.
  • - Research into cross-reactivity highlights connections between shrimp allergies and other animal allergies, leveraging bioinformatics tools to better understand allergen molecular features through methods such as homology analysis and epitope prediction.
  • - Advancements in treatment and diagnosis, including immunotherapy, gene editing, and innovative detection technologies, aim to reduce allergic sensitivity and improve allergy management, offering new strategies for effective prevention and control of food allergies.
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  • Idiopathic pulmonary fibrosis (IPF) is a severe lung disease characterized by progressive damage to alveolar epithelial cells, with limited treatment options and low survival rates.
  • The study focuses on the role of the TSC1 gene, finding that its expression is reduced in IPF and that overexpressing TSC1 can inhibit the epithelial-mesenchymal transition (EMT) process, which is crucial for disease progression.
  • The research also reveals a signaling pathway involving METTL3 and YTHDF2 that regulates TSC1 through mRNA modification, suggesting new potential targets for therapy in IPF.
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This study conducted a comprehensive analysis of the differences in the taste characteristics of hawk black tea and hawk white tea, exploring the intrinsic relationship between nonvolatile metabolites and these taste characteristics. The results revealed significant differences in taste properties of the two types of hawk tea. Hawk black tea mainly exhibits a fresh, sweet, and sweet aftertaste quality, whereas hawk white tea offers a mellow and pure taste.

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Copper, one of the most prolific transition metals in the body, required for normal brain physiological activity and allows various functions to work normally through its range of concentrations. Copper homeostasis is meticulously maintained through a complex network of copper-dependent proteins, including copper transporters (CTR1 and CTR2), the two copper ion transporters the Cu -transporting ATPase 1 (ATP7A) and Cu-transporting beta (ATP7B), and the three copper chaperones ATOX1, CCS, and COX17. Disruptions in copper homeostasis can lead to either the deficiency or accumulation of copper in brain tissue.

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Background: Back pain poses a significant global burden, within which individuals with more severe symptoms consume higher healthcare expenses than those with lesser back pain. Whether measures of body composition predict high-intensity back pain and/or high-disability in population-based cohorts is unknown. This study aimed to examine the association between body composition at baseline and their change in the prior 5 years (between 2001-2005 and 2006-2010) and incident high-intensity back pain and/or high-disability in long-term follow-up, 10 years later (2016-2021) in a population-based cohort of men.

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