Human umbilical mesenchymal stem cells ameliorate atrophic gastritis in aging mice by participating in mitochondrial autophagy through Ndufs8 signaling.

Background: Chronic atrophic gastritis (CAG) is a chronic disease of the gastric mucosa characterized by a reduction or an absolute disappearance of the original gastric glands, possibly replaced by pseudopyloric fibrosis, intestinal metaplasia, or fibrosis. CAG develops progressively into intestinal epithelial metaplasia, dysplasia, and ultimately, gastric cancer. Epidemiological statistics have revealed a positive correlation between the incidence of CAG and age.

Adipocyte-derived CXCL10 in obesity promotes the migration and invasion of ovarian cancer cells.

Background: As a widespread epidemic, obesity poses a significant risk to health and leads to physiological abnormalities, including diabetes mellitus and inflammation. Obesity-induced inflammation can accelerate the development of various cancers; however, the role of obesity in the migration of ovarian carcinoma is still unclear.

Results: Twenty-four commonly upregulated genes were identified from single-cell RNA sequencing datasets of both ovarian carcinoma and adipose tissue of obese humans, with the chemokine CXCL10 showing a significant increase in adipose tissues associated with obesity.

The impact of sodium nitrite and intermittent fasting on neurofilament and tau protein phosphorylation, and spatial learning in rat hippocampus.

In recent years, the influence of dietary-related factors on neurodegenerative diseases has received considerable attention in the academic community, notably involving the food additive sodium nitrite (NaNO) and intermittent fasting behavior. However, the effects of NaNO and intermittent fasting on spatial learning and memory have not been thoroughly investigated. This study conducted a controlled experiment to explore the impact of NaNO and intermittent fasting on the hyperphosphorylation of hippocampal neurofilament (NF) and tau proteins, as well as spatial learning and memory in rats.

Evaluation of the SwiftScan mode in bone single-photon emission computed tomography (SPECT) imaging: effect on imaging quality and a semi-quantitative analysis.

Background: Tc-stannous methylene diphosphonate (Tc-MDP) bone single-photon emission computed tomography/computed tomography (SPECT/CT) imaging plays a crucial role in various clinical applications. Many strategies have been developed to reduce the injection activity and procedure time, improve the patient experience and reduce their anxiety prior to and during SPECT imaging. This study aimed to evaluate the SwiftScan mode and its effect on image quality, and diagnostic performance of malignant skeletal lesions in bone SPECT image.

Associations of risk factors and the number of risk factors with the classification, GMFCS level and comorbidities with cerebral palsy: a retrospective study.

Objective: The objective was to explore the characteristics of risk factors in children with cerebral palsy (CP), focusing on the effects of single risk factors and the number of risk factors on the classification, GMFCS level, and comorbidities of children with CP.

Methods: The medical records of children with CP hospitalized from 2015 to 2023 were reviewed. The effects of nine risk factors, such as hyperbilirubinemia, asphyxia, and HIE, on the classification, GMFCS level and comorbidities of children with CP were studied.

Genome-Wide Association Study and Marker Development for Root Rot Resistance in Soybean.

root rot (FORR) is an important disease threatening soybean production. The development of marker-assisted selection (MAS) molecular markers will help accelerate the disease resistance breeding process and achieve the breeding goal of improving soybean disease resistance. This study evaluated the FORR disease resistance of 356 soybean germplasm accessions (SGAs) and screened resistance-related loci using genome-wide association analysis (GWAS) to develop molecular markers for MAS.

Vortex bifocusing of extreme ultraviolet using modified Fermat-spiral photon-sieve splitter.

Structured beams carrying orbital angular momentum (OAM) provide powerful capabilities for applications in optical tweezers, super-resolution imaging, quantum optics, and ad-vanced microparticle manipulation. However, it is challenging for generate and control the OAM beams at the extreme ultraviolet (EUV) region due to the lack of suitable wave front shaping optics arise from being limited to the strong absorption of most materials. Here, we use a modified Fermat-spiral photon-sieve splitter to simultaneously generate two focused doughnut beams with opposite helical phase.

Freeze-Thaw-Induced Patterning of Extracellular Vesicles with Artificial Intelligence for Breast Cancers Identifications.

Extracellular vesicles (EVs) play a crucial role in the occurrence and progression of cancer. The efficient isolation and analysis of EVs for early cancer diagnosis and prognosis have gained significant attention. In this study, for the first time, a rapid and visually detectable method termed freeze-thaw-induced floating patterns of gold nanoparticles (FTFPA) is proposed, which surpasses current state-of-the-art technologies by achieving a 100 fold improvement in the limit of detection of EVs.

Rhupus syndrome: a unique disease overlapping systemic lupus erythematosus and rheumatoid arthritis.

Background though considered to have characteristics of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) theoretically, Rhupus Syndrome (RS) owns its unique clinical features. In this retrospective cross-sectional study, we included 41 newly diagnosed Rhupus syndrome patients (NRSP). 160 new-diagnosed systemic lupus erythematosus patients (NSLEP) and 709 new-diagnosed rheumatoid arthritis patients (NRAP) were admitted as positive control groups.

Neurotoxicity study of cenobamate-induced zebrafish early developmental stages.

Cenobamate (CNB) is a novel anti-seizure medication with significant efficacy in treating epilepsy. However, in clinical trials, the most common adverse reactions observed in patients are central nervous system (CNS) symptoms. In animal studies, administration of CNB during pregnancy or lactation has been associated with adverse effects on neurodevelopment in offspring.

Digital Economy and carbon emission efficiency in three major urban agglomerations of China: A U-shaped journey towards green development.

Amidst the global consensus on green transformation and sustainable development, the digital economy has emerged as a pivotal catalyst for enhancing carbon emission efficiency. Analyzing panel data of 49 cities in Beijing-Tianjin-Hebei (BTH), Yangtze River Delta (YRD), and Pearl River Delta (PRD) from 2011 to 2022, this study explores the U-shaped journey of the digital economy towards green development. The rebound effect on energy consumption from early digital infrastructure investments delays the long-term benefits of digital applications in boosting carbon performance, and the thresholds of DE in BTH, YRD, and PRD regions are 0.

Potassium molybdate blocks APN-dependent coronavirus entry by degrading receptor via PIK3C3-mediated autophagy.

Swine enteric coronaviruses pose a significant challenge to the global pig industry, inflicting severe diarrhea and high mortality rates among piglets, and resulting in substantial economic losses. In our clinical practice, we observed that the addition of potassium molybdate (PM) to the feed could dramatically reduce diarrhea and diarrhea-related mortality in piglets. However, the underlying mechanisms remain elusive and merit further investigation.

The impact of electrical stimulation on NaCl diffusion in tenderloin and the quality of dry-cured loin during the marination process.

The effects of electrical stimulation (ES) during the post-processing stage on NaCl diffusion, microstructure, and overall quality in the dry curing of pork tenderloin were investigated. ES treatment significantly increased the salt content in pork tenderloin, with the A2ES group (ES applied after 2 h of curing) showing a 28.32 % increase compared to the control group.

Machine learning-based ultrasomics for predicting response to tyrosine kinase inhibitor in combination with anti-PD-1 antibody immunotherapy in hepatocellular carcinoma: a two-center study.

Objective: The objective of this study is to build and verify the performance of machine learning-based ultrasomics in predicting the objective response to combination therapy involving a tyrosine kinase inhibitor (TKI) and anti-PD-1 antibody for individuals with unresectable hepatocellular carcinoma (HCC). Radiomic features can reflect the internal heterogeneity of the tumor and changes in its microenvironment. These features are closely related to pathological changes observed in histology, such as cellular necrosis and fibrosis, providing crucial non-invasive biomarkers to predict patient treatment response and prognosis.

Expression of Brassica napus cell number regulator 6 (BnCNR6) in Arabidopsis thaliana confers tolerance to copper.

Copper is an essential but potential toxic micro-nutrient in rapeseed. So far, little is known about the mechanism of rapeseed Cu transport and detoxification. Here, we determined the function of Cu transporter, Brassica napus cell number regulator 6 (BnCNR6), in regulating Cu homeostasis.

Optimizing Oxygen Redox Activity by Local Chemical Disorder toward Robust Co-Free Li-Rich Cathode with High Voltage Stability.

Despite extensive investigation on the lattice oxygen redox (LOR) in Li-rich cathodes, significant challenges remain in utilizing LOR activity without compromising structural and electrochemical stability. Related breakthroughs are hindered by the lack of understanding regarding how different LOR activity influences the structural evolution and electrochemical stability, and what is the optimal LOR activity. Herein, the degree of LOR activity is successfully regulated from 22% to 92% in Co-free Li-rich cathodes (LiMnNiO) by controlling local chemical disorder, and the relationship between LOR activity and cycling stability is revealed.

Microbial Diversity and Biodegradation Mechanism of Microorganisms in the Dingtao M2 Tomb.

The Dingtao M2 tomb, the largest and best-preserved imperial "Huangchangticou" tomb in China, holds great significance for its conservation. Currently, varying degrees of microbial degradation are occurring on the surfaces of the M2 tomb. This study aimed to determine the microbial diversity of the M2 tomb and its surrounding environment during July 2021 and August 2022.

Enhanced CAD Detection Using Novel Multi-Modal Learning: Integration of ECG, PCG, and Coupling Signals.

Early and highly precise detection is essential for delaying the progression of coronary artery disease (CAD). Previous methods primarily based on single-modal data inherently lack sufficient information that compromises detection precision. This paper proposes a novel multi-modal learning method aimed to enhance CAD detection by integrating ECG, PCG, and coupling signals.