Publications by authors named "Yuanye Shan"
Article Synopsis
- This study investigates the effects of methionine enkephalin (menk) on cervical cancer cell invasion, migration, and natural killer (NK) cell activation within the tumor microenvironment.
- Results indicate that menk inhibits the migration and invasion of cervical cancer cells by influencing epithelial to mesenchymal transition (EMT) markers, specifically increasing E-cadherin while decreasing N-cadherin and vimentin levels.
- In mouse models, menk was shown to enhance expression of certain NK cell markers (IFNγ and NKP46) in tumor tissues while reducing LAG3, suggesting that menk could be a promising avenue for future cervical cancer treatments.
Article Synopsis
- Metastasis is a significant challenge in lung cancer treatment, largely driven by the epithelial-mesenchymal transition (EMT) process, influenced by immune cells in the tumor microenvironment.
- Methionine enkephalin (MENK) may play a role in inhibiting EMT, as it was found to suppress lung cancer cell growth, migration, and invasion by interacting with the opioid growth factor receptor.
- MENK also reduces the presence of tumor-promoting immune cells and decreases levels of specific cytokines, indicating its potential as a therapeutic target for lung cancer metastasis.
There is evidence that methionine enkephalin (MENK), an opioid peptide, promotes anti-tumor immune responses. In this study, the effect of MENK on colorectal cancer (CRC) and its mechanisms of action were examined in vivo. The intraperitoneal administration of 20 mg/kg MENK effectively inhibited MC38 subcutaneous colorectal tumor growth in mice.
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