Publications by authors named "Yuanxiang Shi"

Article Synopsis
  • Hyperlipidemia (HLP) is a key factor in cardiovascular diseases, and quercetin (QUE), a natural flavonoid, shows promise as a treatment, though its exact effects on HLP are still not fully understood.
  • The study utilized advanced techniques like UPLC-Q-Exactive-MS metabolomics and network pharmacology to identify potential therapeutic targets and key metabolic pathways affected by QUE in HLP treatment.
  • Results revealed 138 relevant targets for QUE, with specific proteins (AKT1, TNF, VEGFA, mTOR, SREBP1, and SCD) being highlighted as potential therapeutic focuses; in vitro tests confirmed QUE's effectiveness in modulating these targets against HLP-associated changes.
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Background: Egl-9 family hypoxia-inducible factor 3 (EGLN3) is involved in the regulation of tumor microenvironment and tumor progression. However, its biological function and clinical significance in various cancers remain unclear.

Methods: RNA-seq, immunofluorescence, and single-cell sequencing were used to investigate the expression landscape of EGLN3 in pan-cancer.

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Background: Bladder dysfunction, notably urinary retention, emerges as a significant complication for cervical cancer patients following radical hysterectomy, predominantly due to nerve damage, severely impacting their postoperative quality of life. The challenges to recovery include insufficient pelvic floor muscle training and the negative effects of prolonged postoperative indwelling urinary catheters. Intermittent catheterization represents the gold standard for neurogenic bladder management, facilitating bladder training, which is an important behavioral therapy aiming to enhance bladder function through the training of the external urethral sphincter and promoting the recovery of the micturition reflex.

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Background: Cervical cancer (CC) patients receiving indwelling catheterization after radical hysterectomy (RH) are vulnerable to urinary tract infection (UTI). However, no model or method is available to predict the risk of UTIs. Therefore, our aim was to develop and verify a risk model to predict UTI for patients receiving indwelling catheterization after radical cervical cancer surgery (ICa-RCCS).

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Background: More and more studies have demonstrated that potassium channel tetramerization domain-containing 5 (KCTD5) plays an important role in the development of cancer, but there is a lack of comprehensive research on the biological function of this protein in pan-cancer. This study systematically analyzed the expression landscape of KCTD5 in terms of its correlations with tumor prognosis, the immune microenvironment, programmed cell death, and drug sensitivity.

Methods: We investigated a number of databases, including TCGA, GEPIA2, HPA, TISIDB, PrognoScan, GSCA, CellMiner, and TIMER2.

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Background: During mitosis and meiosis, centromere proteins (CENPs) play a key role in proper chromosome segregation. Abnormal expression of CENPs leads to chromosome instability, which is the main cause of tumorigenesis.

Methods: To elucidate the functional characteristics of CENPs in pan-cancer, we comprehensively analyzed the expression landscape of CENPs and their relationships with patient survival, genomic alterations, tumor immunity, tumor microenvironment, and anticancer drug sensitivity.

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To obtain novel insights into the tumor biology and therapeutic targets of LUAD, we performed a comprehensive analysis of the KCTD family genes. The expression patterns and clinical significance of the KCTD family were identified through multiple bioinformatics mining. Moreover, the molecular functions and potential mechanisms of differentially expressed KCTDs were evaluated using TIMER 2.

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Lung cancer is a major public health problem worldwide, with a high associated incidence and mortality. In the present study, novel epigenetic signatures were identified through genome-wide DNA methylation microarrays. The results revealed that tripartite motif containing 58 (TRIM58), a potential tumor suppressor gene exhibited high methylation and low expression in lung cancer tissue samples compared with normal tissues.

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Article Synopsis
  • - Lung cancer is the most common cause of cancer deaths globally, and its development involves a complex interaction of genetic, environmental, and epigenetic factors.
  • - Key epigenetic mechanisms, such as DNA methylation and noncoding RNAs, play crucial roles in tumorigenesis by affecting important biological processes and signaling pathways.
  • - Research into epigenetic changes not only enhances our understanding of how lung cancer develops but also offers potential for developing biomarkers for early diagnosis, prognosis, and targeted therapies.
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  • The study aimed to uncover epigenetic changes linked to squamous cell lung cancer (LUSC) through genome-wide DNA methylation profiling, analyzing 24 LUSC samples alongside non-tumor tissues.
  • Researchers identified 5,214 differentially methylated regions and pinpointed 449 genes with both altered methylation and expression, many associated with cancer-related signaling pathways.
  • Validation with independent tissue samples and TCGA data led to the discovery of a panel of DNA methylation biomarkers (including CLDN1 and TP63), suggesting their potential as diagnostic tools for LUSC.
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Article Synopsis
  • * The research identified three genes—NEK2, DLGAP5, and ECT2—that are highly expressed in lung cancer tumors, and their elevated levels were confirmed through laboratory tests.
  • * Analysis showed that these genes can effectively differentiate lung cancer patients from healthy individuals and are linked to poorer survival outcomes, suggesting their potential use as biomarkers in clinical settings.
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Lung cancer remains as the leading cause of cancer-related death worldwide, and lung adenocarcinoma (LUAD) is the most common histological subtype. This study aims to investigate biomarkers associated with cancer progression and prognosis of LUAD. We integrated expression profiles of 668 lung cancer patients in five datasets from the Gene Expression Omnibus (GEO) and identified a panel of differentially expressed genes (DEGs).

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Mycobacterium bovis is the causative agent of bovine tuberculosis (bTB). The proteins Ag85B, MPB64, and ESAT-6 are the major immunogenic antigens of M. bovis; these proteins play important roles in inducing immune responses that confer resistance against infections.

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