Publications by authors named "Yuanxi Shen"

Article Synopsis
  • Schistosomiasis japonica is a parasitic disease that affects different host species, with variations in microRNA-181a expression observed in susceptible BALB/c mice and resistant reed voles post-infection, suggesting it may play a role in immune response regulation against the parasite.* -
  • Experimental methods involved infecting various mouse models, including TLR4-deficient and wild-type mice, with S. japonicum, and measuring miR-181a expression and the levels of key cytokines over time to assess immune response.* -
  • Results showed that miR-181a expression was elevated in BALB/c mice but decreased in reed voles, correlating with differences in cytokine levels, and highlighted the
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Background: Schistosomiasis japonica is a severe zoonosis. Domestic animals are the primary source of infection and play an important role in disease transmission. Surveillance and diagnosis play key roles in schistosomiasis control; however, current techniques for the surveillance and diagnosis of the disease have limitations.

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Currently the diagnosis of schistosomiasis is mainly determined by observing the presence of eggs in host stool samples. Because of the overwhelming number of impurities in the stool, eggs are rarely observed. Therefore, the stool hatching method is used to observe the miracidia in the water.

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Background: The existing diagnostic techniques for detecting schistosomiasis turkestanica, such as aetiological assays, identify infection by parasitic worms via the incubation of miracidia from faeces or observing eggs under microscopy. However, they are limited in the diagnosis of low-grade and prepatent infections, which lead to a high misdetection rates. Therefore, a new method for parasite diagnosis with increased sensitivity is urgently needed.

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Background: Schistosomiasis is a huge threat to human and animal health. Apart from bovines, goats play an important role in the transmission of schistosomiasis in some endemic areas of China. An accessible, quality-assured goat schistosomiasis diagnostic technique is needed.

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