Publications by authors named "Yuanxi Jia"
Article Synopsis
- The study addresses the growing public health issue of herpes simplex type 2 (HSV-2) infections in China, highlighting the need for better intervention strategies based on epidemiological data.
- A systematic review of 23,999 articles resulted in 402 publications being analyzed, revealing a general HSV-2 seroprevalence of 7.7%, with higher rates among intermediate-risk (14.8%) and key populations (31.7%), particularly among female sexual workers.
- Findings indicate significant regional disparities in HSV-2 prevalence, with northeastern China having higher rates, and a notable difference in prevalence estimates between Chinese and English publications among key populations.
Article Synopsis
- The study aimed to determine how common it is for meta-analyses to include randomized controlled trials (RCTs) that may be redundant—meaning they started after a key result had already been established in previous studies.
- The research involved analyzing a sample of 4,500 references from recent systematic reviews and meta-analyses published in major medical databases, ultimately focusing on 448 eligible meta-analyses of interventions combining RCTs only.
- Out of the analyzed meta-analyses, 12.7% were found to contain potentially redundant RCTs, amounting to a total of 295 potentially redundant trials involving over 85,000 participants, suggesting a significant degree of overlap in the data used across these studies. *
Importance: Systematic reviews can help to justify a new randomized clinical trial (RCT), inform its design, and interpret its results in the context of prior evidence.
Objective: To assess trends and factors associated with citing (a marker of the use of) prior systematic reviews in RCT reports.
Design, Setting, And Participants: This cross-sectional study investigated 737 Cochrane reviews assessing health interventions to identify 4003 eligible RCTs, defined as those included in an updated version but not in the first version of a Cochrane review and published 2 years after the first version of the Cochrane review was published.
Background: The efficacy of SARS-CoV-2 vaccines in preventing severe COVID-19 illness and death is uncertain due to the rarity of data in individual trials. How well the antibody concentrations can predict the efficacy is also uncertain. We aimed to assess the efficacy of these vaccines in preventing SARS-CoV-2 infections of different severities and the dose-response relationship between the antibody concentrations and efficacy.
View Article and Find Full Text PDFBackground: Redundant clinical trials waste resources and unnecessarily put patients at risk for harm. The objectives of the study were to assess redundant randomized clinical trials (RCTs) conducted in mainland China or the USA among patients with ST segment elevation myocardial infarction (STEMI) and estimate the harm to patients enrolled in redundant RCTs.
Methods: We searched bibliographic databases for eligible RCTs comparing a routine therapy with a placebo or no treatment among patients with STEMI in mainland China or the United States.
We conducted a scoping review to map available evidence about the health impact of gut microbiota-derived metabolites. We searched PubMed and Embase for studies that assessed the health impact of ten metabolites on any health condition: deoxycholate or deoxycholic acid (DCA), lithocholate or lithocholic acid (LCA), glycolithocholate or glycolithocholic acid, glycodeoxycholate or glycodeoxycholic acid, tryptamine, putrescine, d-alanine, urolithins, N-acetylmannosamine, and phenylacetylglutamine. We identified 352 eligible studies with 168,072 participants.
View Article and Find Full Text PDFLutein, zeaxanthin, and meso-zeaxanthin are the only carotenoids found in the human macula and may have a role in visual function. These carotenoids are reported to protect the retina, and thus vision, as antioxidants and by acting as a blue light filter. Our objective was to determine a minimum concentration of lutein/zeaxanthin intake that is associated with a statistically significant and/or clinically important change in macular pigment optical density (MPOD) among adults with healthy eyes.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to identify unnecessary clinical trials assessing statin treatment in coronary artery disease patients in mainland China and quantify the additional major adverse cardiac events (MACEs) caused by withholding statins in these trials.
- Analysis of 2577 trials revealed 2045 redundant trials published after 2008, involving 101,486 patients not treated with statins, resulting in 3470 extra MACEs.
- The findings indicate that not administering statins in these trials could have prevented a significant number of adverse events, including deaths and myocardial infarctions.
Background And Objective: To evaluate the association between the nature of findings and the switching of registered primary outcomes among randomized controlled trials (RCTs) from mainland China.
Methods: This is a retrospective cohort study. We retrieved RCTs from trial registries and identified the corresponding journal articles from bibliographic databases until August 2019.
Importance: Duplicate publications of randomized clinical trials are prevalent in the health-related literature. To date, few studies have assessed the interaction between duplicate publication and the language of the original publication.
Objective: To assess the existence of duplicate publication and the extent to which duplicate publication is associated with the language of the original publication.
Introduction: Hepatitis B virus (HBV) remains a public health threat and the main route of transmission is from mother to child (MTCT). Tenofovir disoproxil fumarate (TDF) treatment can reduce MTCT of HBV although the optimal timing to attain undetectable HBV DNA concentrations at delivery is unknown. This protocol describes the procedures following early initiation of maternal TDF prior to 20 weeks gestation to determine efficacy, safety and feasibility of this approach in a limited-resource setting.
View Article and Find Full Text PDFImportance: Language and indexing biases may exist among Chinese-sponsored randomized clinical trials (CS-RCTs). Such biases may threaten the validity of systematic reviews.
Objective: To evaluate the existence of language and indexing biases among CS-RCTs on drug interventions.
Purpose: To identify currently available patient-reported outcome measures (PROMs) used in patients with foot or ankle diseases; and to critically appraise, compare and synthesize the psychometric evidence for the identified PROMs.
Methods: Literature searches were performed in Medline and EMBASE from their inception to January 25th, 2016. Methodological quality was evaluated using the COSMIN checklist.
Vaccination in prevention mother-to-child transmission (PMTCT) of hepatitis B has been recommended since plasma-derived hepatitis B vaccines became available in China in 1986; however, less study evaluated practice effectiveness of PMTCT systematically. We conducted a prospective survey to evaluate the effectiveness of PMTCT practices in 3 provinces of southern China. We selected prefectures with low timely birth dose coverage in Yunnan, Guangxi, and Hunan provinces.
View Article and Find Full Text PDFObjective: The aim of the study was to estimate long-term cost‑effectiveness of a hepatitis B vaccination catch-up program among children born between 1994 and 2001 (when they were 8‑15 y old) in Shandong province, China, to provide information for nationwide evaluation and future policy making.
Methods: We determined the cost-effectiveness of the catch-up program compared with the status quo (no catch-up program). We combined a Decision Tree model and a Markov model to simulate vaccination and clinical progression after hepatitis B virus (HBV) infection.