Cobalt-based CoMoN/CoN/Co Metallic Heterostructure as a Highly Active Electrocatalyst for Alkaline Overall Water Splitting.

Alkaline water electrolysis holds promise for large-scale hydrogen production, yet it encounters challenges like high voltage and limited stability at higher current densities, primarily due to inefficient electron transport kinetics. Herein, a novel cobalt-based metallic heterostructure (CoMoN/CoN/Co) is designed for excellent water electrolysis. In operando Raman experiments reveal that the formation of the CoMoN/CoN heterointerface boosts the free water adsorption and dissociation, increasing the available protons for subsequent hydrogen production.

Giant Blue Energy Harvesting in Two-Dimensional Polymer Membranes with Spatially Aligned Charges.

Blue energy between seawater and river water is attracting increasing interest, as one of the sustainable and renewable energy resources that can be harvested from water. Within the reverse electrodialysis applied in blue energy conversion, novel membranes with nanoscale confinement that function as selective ion transport mediums are currently in high demand for realizing higher power density. The primary challenge lies in constructing well-defined nanochannels that allow for low-energy barrier transport.

Identification of Two Immune Related Genes Correlated With Aberrant Methylations as Prognosis Signatures for Renal Clear Cell Carcinoma.

Almost 75% of renal cancers are renal clear cell carcinomas (KIRC). Accumulative evidence indicates that epigenetic dysregulations are closely related to the development of KIRC. Cancer immunotherapy is an effective treatment for cancers.

Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance.

In obesity, macrophages drive a low-grade systemic inflammation (LSI) and insulin resistance (IR). The ribosome biosynthesis protein NOC4 (NOC4) mediates 40 S ribosomal subunits synthesis in yeast. Hereby, we reported an unexpected location and function of NOC4L, which was preferentially expressed in human and mouse macrophages.

Immune-Related lncRNAs to Construct Novel Signatures and Predict the Prognosis of Rectal Cancer.

Colorectal cancer (CRC) is one of the most common cancers. Almost 1/3 of CRC are rectal cancer, and 95% of rectal cancers are rectal adenocarcinoma (READ). Increasing evidences indicated that long noncoding RNAs (lncRNAs) have important role in the genesis and development of cancers.

Immune-Related Gene Expression Analysis Revealed Three lncRNAs as Prognostic Factors for Colon Cancer.

Colorectal cancer (CRC) is one of the most common cancers. Almost 80% of CRC cases are colon adenocarcinomas (COADs). Several studies have indicated the role of immunotherapy in the treatment of various cancers.

Reducing embryonic mtDNA copy number alters epigenetic profile of key hepatic lipolytic genes and causes abnormal lipid accumulation in adult mice.

Adverse fetal environment, in particular a shortage or excess of nutrients, is associated with increased risks of metabolic diseases later in life. However, the molecular mechanisms underlying this developmental origin of adult diseases remain unclear. Here, we directly tested the role of mitochondrial stress in mediating fetal programming in mice by enzymatically depleting mtDNA in zygotes.

Gene expression and DNA methylation analyses suggest that two immune related genes are prognostic factors of colorectal cancer.

Background: Colorectal cancer (CRC) is the second most prevalent cancer, as it accounts for approximately 10% of all annually diagnosed cancers. Studies have indicated that DNA methylation is involved in cancer genesis. The purpose of this study was to investigate the relationships among DNA methylation, gene expression and the tumor-immune microenvironment of CRC, and finally, to identify potential key genes related to immune cell infiltration in CRC.

MicroRNA related prognosis biomarkers from high throughput sequencing data of kidney renal clear cell carcinoma.

Background: Kidney renal clear cell carcinoma (KIRC) is the most common type of kidney cell carcinoma which has the worst overall survival rate. Almost 30% of patients with localized cancers eventually develop to metastases despite of early surgical treatment carried out. MicroRNAs (miRNAs) play a critical role in human cancer initiation, progression, and prognosis.

Quantification of circadian rhythm in mitochondrial DNA copy number in whole blood, and identification of factors that influence it.

Mitochondrial DNA (mtDNA), the genetic material in mitochondria, encodes key genes related to the respiratory chain and ATP production. To accurate quantification mtDNA content in whole blood is important for various disease states. Absolute quantitative Real-time PCR and platelet contamination erase method were used for mtDNA copy number analysis in whole blood.

MicroRNA-Related Prognosis Biomarkers from High-Throughput Sequencing Data of Colorectal Cancer.

Background: Colorectal cancer (CRC) is the third most common cancer in the world, and most of them are adenocarcinomas. CRC could be classified as colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) according to the original tumorigenesis position. Increasing evidences indicated that microRNAs (miRNAs) play an important role in the occurrence of multiple tumors.

Surface-Induced 2D/1D Heterostructured Growth of ReS/CoS for High-Performance Electrocatalysts.

Two-dimensional/one-dimensional (2D/1D) heterostructures have received much attention from researchers for their abundant catalytically active sites and low contact resistance due to formation of chemical bonds at the interface. The investigation of such heterostructures, however, is confined to lattice-matched materials, which severely limits the material candidates. Herein, we demonstrate a lattice-mismatched 2D/1D heterostructured electrocatalyst consisting of 2D ReS nanosheets and 1D CoS nanowires.

Enhanced charge transport in ReSe-based 2D/3D electrodes for efficient hydrogen evolution reaction.

Ultra-high-density rhenium diselenide (ReSe2) nanoflakes were synthesized on a porous carbon cloth (PCC) by chemical vapor deposition (CVD). Besides the two-dimensional/three-dimensional (2D/3D) construction with more active catalytic sites, the small size effect together with the interfacial C-Se bonding facilitated the electron transport between ReSe2 and PCC. Hence, the heat-treated ReSe2@PCC with enhanced charge transport is by far the best performance electrode for the hydrogen evolution reaction (HER) among the state-of-the-art ReX2-based electrodes.

Ebola virus encodes a miR-155 analog to regulate importin-α5 expression.

The 2014 outbreak of Ebola virus caused more than 10,000 human deaths. Current knowledge of suitable drugs, clinical diagnostic biomarkers and molecular mechanisms of Ebola virus infection is either absent or insufficient. By screening stem-loop structures from the viral genomes of four virulence species, we identified a novel, putative viral microRNA precursor that is specifically expressed by the Ebola virus.

Perinatal exposure to low-dose methoxychlor impairs testicular development in C57BL/6 mice.

Methoxychlor (MXC), an organochlorine pesticide, has adverse effects on male reproduction at toxicological doses. Humans and wild animals are exposed to MXC mostly through contaminated dietary intake. Higher concentrations of MXC have been found in human milk, raising the demand for the risk assessment of offspring after maternal exposure to low doses of MXC.

Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat.

It is important to clarify the distinct contributions of estrogen/estrogen receptor (ER) and androgen/androgen receptor (AR) signaling and their reciprocal effects on the regulation of hepatic lipid homeostasis. We studied the molecular mechanisms underlying the preventive effects of estradiol (E2), dihydrotestosterone (DHT), or E2+DHT on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in an orchidectomized Sprague-Dawley (SD) rat model. E2 is shown to be associated with decreased fatty acid synthesis in hepatic zone 3-specific manner by increasing the phosphorylation of acetyl coenzyme-A carboxylase via an ERα-mediated pathway.