Enhancing Urine Glucose Sensing Performance through the Introduction of Two Dimensional-Transition Metal Dichalcogenides and Gold Nanoparticles into Silver/UiO-66 Chip of Surface Plasmon Resonance.

This work presents a high-performance surface plasmon resonance (SPR)-based biosensor for glucose detection. While adding a metal-organic framework (MOF) layer, UiO-66, to the biosensor improves selectivity and enables direct detection without additional receptors, it does not significantly enhance sensitivity. A SPR-based biosensor is proposed to overcome this limitation by introducing a layer of 2D-transition metal dichalcogenides (2D-TMD) and decorating the UiO-66 structure with gold nanoparticles (UiO-66AuNP).