Benzocyclobutene-functionalized hyperbranched polysiloxane for low-k materials with good thermostability.

Although hyperbranched polysiloxanes have been extensively studied, they have limited practical applications because of their low glass transition temperatures. In this study, we synthesized benzocyclobutene-functionalized hyperbranched polysiloxane (HB-BCB) via the Piers-Rubinsztajn reaction. The synthesized material was cured and crosslinking occurred at temperatures greater than 200 °C, forming a low-k thermoset resin with high thermostability.

Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway.

Liver fibrosis is a progression of chronic liver disease, which lacks effective therapies in the world. Attractively, more and more evidences show that natural products are safe and effective in the prevention and treatment of hepatic fibrosis. Artesunate, a water-soluble hemisuccinate derivative of artemisinin, exerts various pharmacological activities such as anti-inflammatory, anti-tumor and immunomodulating abilities.

Synthesis and anticancer activity of novel rapamycin C-28 containing triazole moiety compounds.

Rapamycin is an mTOR allosteric inhibitor with multiple functions such as immunosuppressive, anticancer, and lifespan prolonging activities. Its C-43 semi-synthetic derivatives temsirolimus and everolimus have been used as mTOR targeting anticancer drugs in the clinic. Following our previous research on antitumor rapalogs modified on the C-43 position, 13 novel rapamycin triazole hybrids (6a-g, 7a-f) were designed and synthesized on the C-28 position of rapamycin via Huisgen's reaction.

Removable Large-Area Ultrasmooth Silver Nanowire Transparent Composite Electrode.

In this work, a composite silver nanowire (AgNW) transparent electrode that is large-area ultrasmooth without conductivity or transmittance scarifice, removable but with good resistance to both water and organic solvent, is reported. Via a simple low-temperature solution process without complicated transfer steps or additional pressure pressing, a new kind of AgNWs composite with biocompatible and patternable chitosan polymer complex demonstrates a quite low root-mean-square roughness ∼7 nm at a largest reported scan size of 50 μm × 50 μm, which is among the best flat surface. After long-term exposure to both water and organic solvent, it still shows strong adhesion, unchanged transparency, and no obvious conductivity reduction, suggesting a good stability staying on the substrate.

Synthesis of Rapamycin Derivatives Containing the Triazole Moiety Used as Potential mTOR-Targeted Anticancer Agents.

Rapamycin, a potent antifungal antibiotic, was approved as immunosuppressant, and lately its derivatives have been developed into mTOR targeting anticancer drugs. Structure modification was performed at the C-42 position of rapamycin, and a novel series of rapamycin triazole hybrids (4a-d, 5a-e, 8a-e, and 9a-e) was facilely synthesized via Huisgen's reaction. The anticancer activity of these compounds was evaluated against the Caski, H1299, MGC-803, and H460 human cancer cell lines.

Design, Synthesis and Biological Evaluation of Novel Rapamycin Benzothiazole Hybrids as mTOR Targeted Anti-cancer Agents.

The immunosuppressant drug rapamycin, was firstly identified as a mammalian target of rapamycin (mTOR) allosteric inhibitor, and its derivatives have been successfully developed as anti-cancer drugs. Therefore, finding rapamycin derivatives with better anti-cancer activity has been proved to be an effective way to discover new targeted anti-cancer drugs. In this paper, structure modification was performed at the C-43 position of rapamycin using bioisosterism and a hybrid approach: a series of novel rapamycin-benzothiazole hybrids 4a-e, 5a-c, and 9a, b have been designed, synthesized and evaluated for their anti-cancer activity against Caski, CNE-2, SGC-7901, PC-3, SK-NEP-1 and A-375 human cancer cell lines.

Annealing-free and strongly adhesive silver nanowire networks with long-term reliability by introduction of a nonconductive and biocompatible polymer binder.

As a promising candidate to replace the brittle and expensive transparent indium tin oxide (ITO) conductor, the use of silver nanowire (AgNW) networks still involves issues such as high-temperature post-treatments and poor substrate adhesion for industrial application. Here a room-temperature soldering and one-step solution method is developed to achieve high-performance Ag nanowire transparent conductive films (TCFs). A nonconductive binder is prepared from poly(dopamine) and alginic acid which contains abundant catechol and carboxylic acid functional groups.

ZnS nanoparticles well dispersed in ethylene glycol: coordination control synthesis and application as nanocomposite optical coatings.

The study of the preparation and application of ZnS nanoparticles (NPs) has been one of the most prominent hotspots in the domain of semiconductor NPs. The ZnS NPs usually exist in two crystallographic forms: zinc blende (cubic) and wurtzite (hexagonal). However, controlled preparation of ZnS NPs with specified crystallographic forms is still a difficult problem.

Site-selective growth of patterned silver grid networks as flexible transparent conductive film by using poly(dopamine) at room temperature.

Metal transparent conductive films (TCFs) have received increasing attention in various flexible electronics. However, there are two crucial issues that need to be addressed: (1) strong adhesion between metal TCFs and the flexible substrates and (2) high conductivity with short treatment time and low process temperature, simultaneous with high transparency. In this paper, a site-selective electroless plating combination with poly(dopamine) modification is demonstrated to fabricate a new high performance transparent conductor composed of a periodic two-dimensional silver network on a heat sensitive flexible substrate at room temperature.

FIM-A, a phosphorus-containing sirolimus, inhibits the angiogenesis and proliferation of osteosarcomas.

The mTOR pathway is a central control of cell growth, proliferation, metabolism, and survival, and is deregulated in most cancers. Cancer cells are addicted to increased activity of mTOR kinase-mediated signaling pathways, leading to numerous inhibitors of mTOR signaling in preclinic and clinical trials for cancer therapy. Phosphorus-containing sirolimus (FIM-A), which targets mTOR signaling, inhibits cancer cell growth in vitro.

Copper nanoparticles: aqueous phase synthesis and conductive films fabrication at low sintering temperature.

Conductive copper nanoinks can be used as a low-cost replacement for silver and gold nanoinks that are used in inkjet printing of conductive patterns. We describe a high-throughput, simple, and convenient method for the preparation of copper nanoparticles in aqueous solution at room temperature. Copper acetate is used as the precursor, hydrazine as the reducing agent, and short chain carboxylic acids as capping agents.

40-De-oxy-40(S)-iodo-rapamycin.

The title compound, C(51)H(78)INO(12), contains a 29-membered ring incorporating amide, lactone and ester groups. It contains a total of 15 stereogenic centres. In the crystal, mol-ecules are linked by O-H⋯O hydrogen bonds, forming C(8) chains propagating in [100].

41-Azido-41-de-oxy-rapamycin.

The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bonding associations, giving one-dimensional chains extending along (010).

Facile approach in fabricating superhydrophobic and superoleophilic surface for water and oil mixture separation.

Metal copper mesh with superhydrophobic and superoleophilic surface had been successfully fabricated via a facile solution-immersion process. The hierarchical structure was prepared on the commercial copper mesh surface by etching with the nitric acid. After being modified by 1-hexadecanethiol (HDT), the as-prepared mesh indicated both superhydrophobic and superoleophilic property simultaneously.