Publications by authors named "Yuanqu Lin"
Objective: The present study aimed to see if 20-Deoxyingenol(20-DOI) could protect hippocampus neurons from the neurotoxic effects of morphine and reduce memory loss in rats.
Method: Male Wistar rats were given morphine hydrochloride (45 mg/kg, sc, four weeks) and 20-DOI (10, 20 mg/kg, ip., coadministered with morphine) for the Morris Water Maze (MWM) test to investigate the effects of 20-DOI on spatial learning and memory.
Background: As a class of analgesics, opioids are frequently used to treat both acute and chronic moderate to severe pain. Patients frequently receive opioid painkillers after orthopedic accidents or surgeries. Evidence suggests that opioid drug users have a 55.
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- - Osteoarthritis (OA) is a common degenerative joint disease that leads to cartilage damage and can cause disability, driven primarily by inflammation and the breakdown of the extracellular matrix.
- - BF-30, a natural peptide from snake venom, has shown potential in reducing inflammation and improving the health of joint tissue, although the exact mechanism was previously unclear.
- - Research indicates that BF-30’s beneficial effects in treating OA occur through activation of the AMPK/SIRT1/NF-κB pathway, and its therapeutic action can be reversed when paired with an AMPK inhibitor.