Publications by authors named "Yuanqingxiao Li"
Article Synopsis
- Liver fibrosis is associated with altered bile acids, which can trigger inflammatory responses; this study investigates the specific bile acids involved and their role in liver fibrosis progression.
- Higher levels of certain bile acids like GCDCA were found in patients with liver fibrosis, and GCDCA promotes the proliferation and migration of liver cells through the NLRP3 inflammasome pathway.
- FXR is identified as a potential regulator that inhibits NLRP3 activation, and strategies targeting NLRP3 could help mitigate the development of liver fibrosis.
Background: Hepatic stellate cell (HSC) hyperactivation is a central link in liver fibrosis development. HSCs perform aerobic glycolysis to provide energy for their activation. Focal adhesion kinase (FAK) promotes aerobic glycolysis in cancer cells or fibroblasts, while FAK-related non-kinase (FRNK) inhibits FAK phosphorylation and biological functions.
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