Sodium New Houttuyfonate Affects Transcriptome and Virulence Factors of Controlled by Quorum Sensing.

As a major opportunistic pathogen, can produce various virulence factors and form biofilms. These processes are controlled by the quorum sensing (QS) system. Sodium new houttuyfonate (SNH) is an adduct of houttuyfonate, the main component of the common Chinese medicine plant Houttuynia cordata, which has antibacterial and anti-inflammatory effects.

Sodium New Houttuyfonate Inhibits Biofilm Formation by Inhibiting the Ras1-cAMP-Efg1 Pathway Revealed by RNA-seq.

Here, we aim to investigate the antifungal effect and mechanism of action of sodium new houttuyfonate (SNH) against . Microdilution analysis results showed that SNH possesses potent inhibitory activity against SC5314, with a MIC of 256 μg/mL. Furthermore, we found that SNH can effectively inhibit the initial adhesion of .

Effects of sodium houttuyfonate on transcriptome of Pseudomonas aeruginosa.

Objectives: The purpose of this experiment is to analyze the changes of transcriptome in Pseudomonas aeruginosa under the action of sodium houttuyfonate (SH) to reveal the possible mechanism of SH inhibiting P. aeruginosa. We analyzed these data in order to compare the transcriptomic differences of P.