Publications by authors named "Yuanqin Hu"
Article Synopsis
- Aerobic respiration is crucial for cell growth and infection, and knockout experiments revealed a downregulation of genes linked to NADH and ATP synthesis in this process.
- Non-targeted metabolomics demonstrated that the metabolites influenced by the knockout were tied to aerobic respiration, leading to decreased levels of NADH and ATP independent of the σ pathway.
- The study found that the DegS protease regulates the expression of isocitrate dehydrogenase (ICDH) through a factor called ArcA, impacting NADH and ATP levels, growth rates, and intestinal colonization ability in certain strains.
Toll-like receptors (TLRs) are the primary sensors detecting conserved molecular patterns on microorganisms, thus acting as important components of innate immunity against invading pathogens. Many positive and negative regulators of TLR-triggered signaling have been identified. The Rho GTPase RhoB plays a key role in cell migration, division and polarity; however, the function and regulatory mechanisms of RhoB in TLR ligand-triggered innate immune responses remain to be investigated.
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