[Advances in clinical management of neonatal sepsis].

Neonatal sepsis, as a significant cause of various complications and adverse outcomes in neonates, remains a serious health burden both domestically and internationally. Strategies such as antibiotic prophylaxis during delivery, the utilization of early-onset sepsis risk calculators, and quality improvement initiatives in neonatal wards are beneficial in alleviating the disease burden of neonatal sepsis. This paper provides a review of the epidemiology, risk factors, and recent advances in clinical management of neonatal sepsis.

Docosahexaenoic acid improves cognition and hippocampal pyroptosis in rats with intrauterine growth restriction.

Background And Objective: Intrauterine growth restriction (IUGR) is defined as the failure of a fetus to reach its genetic growth potential in utero resulted by maternal, placental, fetal, and genetic factors. Previous studies have reported that IUGR is associated with a high incidence of neurological damage, although the precise causes of such damage remain unclear. We aimed to investigate whether cognitive impairment in rats with IUGR is related to pyroptosis of hippocampal neurons and determine the effect of early intervention with docosahexaenoic acid (DHA).

[A 10-year retrospective study of pathogens and antimicrobial resistance in neonatal sepsis].

Objectives: To investigate the changes in the pathogen spectrum and antimicrobial resistance over time in neonatal sepsis.

Methods: The medical data were collected from the neonates who were diagnosed with sepsis in the Second Xiangya Hospital of Central South University from January 2010 to December 2019. The incidence rate of sepsis, the pathogen spectrum, and the characteristics of antimicrobial resistance were analyzed.

Etiology and clinical characteristics of neonatal sepsis in different medical setting models: A retrospective multi-center study.

Objective: General hospitals admit lower gestational age neonates than maternal and child health care centers, therefore associated with a higher morbidity and mortality. This study aimed to assess the etiology and clinical characteristics of neonatal sepsis in different medical setting models.

Methods: Neonates admitted to 5 tertiary medical centers, including one national general hospital, two maternal and child health care hospitals and two regional general hospitals, in central-south China with culture-proven sepsis between January 2010 and December 2019 were included in the study.

Etiology, antimicrobial resistance, and risk factors of neonatal sepsis in China: a systematic review and meta-analysis from data of 30 years.

Objective: To evaluate the regional etiology, antimicrobial resistance (AMR) pattern, and risk factors in neonates with sepsis in China.

Methods: We performed a systematic review and meta-analysis by searching Medline, Embase, Scopus, and Web of Science in December 2020. Studies of neonatal sepsis from China published between 2011 and 2020 were included.

Correction to: Clinical characterization, genetic profiling, and immune infiltration of TOX in diffuse gliomas.

An amendment to this paper has been published and can be accessed via the original article.

Clinical characterization, genetic profiling, and immune infiltration of TOX in diffuse gliomas.

Background: Immunotherapies targeting glioblastoma (GBM) have led to significant improvements in patient outcomes. TOX is closely associated with the immune environment surrounding tumors, but its role in gliomas is not fully understood.

Methods: Using data from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA), we analyzed the transcriptomes of 1691 WHO grade I-IV human glioma samples.

Coronavirus Disease 2019 (COVID-19) in Neonates and Children From China: A Review.

At the end of 2019, a novel coronavirus began to spread in Wuhan, Hubei Province, China. The confirmed cases increased nationwide rapidly, in part due to the increased population mobility during the Chinese Lunar New Year festival. The World Health Organization (WHO) subsequently named the novel coronavirus pneumonia Coronavirus Disease 2019 (COVID-19) and named the virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2).

Glioblastoma Treatment Modalities besides Surgery.

Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy from surgery, chemotherapy, to radiotherapy. Efforts in recent decades have brought many novel therapies to light, however, with limitations.

Influence of voltage rise time on operation frequency in magnetically insulated transmission line oscillator.

In the experiments of a magnetically insulated transmission line oscillator (MILO), the initiatory microwave frequency is slightly higher than the stable microwave frequency. This paper investigates the influence of the front edge of the voltage on microwave frequency. The theoretical analysis shows that the MILO operates at the 2π mode in the initiatory stage; therefore, the microwave frequency is determined by the single slow wave structure (SWS) cavity.

Performance improvement of a magnetically insulated transmission line oscillator with a carbon fiber array cathode.

A carbon fiber array cathode (CFAC) was presented and tested in a magnetically insulated transmission line oscillator (MILO) in earlier papers; however, the performance of this cathode was not as good as the traditional polymer velvet cathode, and the nonuniform fibers' distribution on the cathode surface was postulated as the culprit for this. In this paper, this CFAC has been carefully reprocessed, and the performance is improved (efficiency increases from ∼12% to ∼16%) and reaches a level that is as good as the velvet cathode, which means that this CFAC provides a promising substitute for the polymer velvet cathode in MILO.