Publications by authors named "Yuanmin Qian"
Article Synopsis
- The study explores how disruptions in the cervicovaginal microbiome, particularly through the production of indoleacrylic acid (IAA), influence the development of gynecological cancers like endometrial cancer (EC).
- Researchers found that IAA production from certain bacterial species can promote tumor growth and affect immune cell dynamics in both patients and mouse models.
- The results indicate a connection between higher levels of IAA, increased IDO1 expression, and altered immune responses, suggesting that certain bacterial species may contribute to immune tolerance in endometrial cancer.
Article Synopsis
- Epigenetic changes, particularly DNA methylation, are common during the early stages of nasopharyngeal carcinoma (NPC) development, with TRIM29 being identified as hypomethylated and overexpressed in NPC cells and tissues.
- Silencing TRIM29 limits NPC cell growth, induces cellular aging, and increases reactive oxygen species (ROS), highlighting its role in cancer progression.
- TRIM29's interaction with VDAC1 promotes mitophagy, helping to clear damaged mitochondria and reduce ROS levels; this suggests that monitoring TRIM29's methylation status in nasopharyngeal swab DNA could aid in early NPC detection.
Previous studies have demonstrated that polymorphisms in the gene are associated with various types of cancer. In neuroblastoma, protein product regulates N-myc protein levels and plays a critical role in tumorigenesis. To investigate the association between three polymorphisms (rs1047972 C>T, rs2273535 T>A, and rs8173 G>C) and neuroblastoma susceptibility in Chinese populations, we performed this two-center case-control study including 393 neuroblastoma cases and 812 controls.
View Article and Find Full Text PDFDiagnosis of endometrial cancer is primarily based on symptoms and imaging, with early-stage disease being difficult to diagnose. Therefore, development of potential diagnostic biomarkers is required. Metabolomics, a quantitative measurement of the dynamic metabolism in living systems, can be applied to determine metabolite profiles in different disease states.
View Article and Find Full Text PDFBackground: Uric acid is a product of purine metabolism. Recently, uric acid has gained much attraction in cancer. In this study, we aim to investigate the clinicopathological and prognostic significance of serum uric acid concentration in breast cancer patients.
View Article and Find Full Text PDFCell cycle protein Bora has been identified to integrate the functions of three major mitotic kinases: Cyclin-dependent kinase-1, Polo-like kinase-1, and Aurora A kinase. Overexpression of Bora disrupts spindle assembly and causes genomic instability. However, the clinical relevance of Bora in cancer remains unclear.
View Article and Find Full Text PDFHistone deacetylases (HDACs) play crucial roles in the initiation and progression of cancer, offering a promising target for cancer therapy. HDACs inhibitor MGCD0103 (MGCD) exhibits effective anti-tumor activity by blocking proliferation and inducing cell death in malignant cells. However, the molecular mechanisms of HDACs inhibition induces cell death have not been well elucidated.
View Article and Find Full Text PDFBackground: Platinum-based chemotherapy improves survival among patients with non-small cell lung cancer (NSCLC), but the efficiency is limited due to resistance. In this study, we aimed to identify the expression of Aurora-A and its correlation with cisplatin resistance and prognosis in NSCLC.
Methods: We used immunohistochemical analysis to determine the expression of Aurora-A protein in 102 NSCLC patients treated by surgery and adjuvant cisplatin-based chemotherapy.