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Publications by authors named "Yuanmei Lu"

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Work stress and competency among radiology residents: the mediating effect of resilience.
Lijun Shen Yuanmei Lu Yanrong He Peicheng Wang Yanhua Chen

Front Public Health

October 2024

Background: Competency of health professionals stands as a fundamental element in ensuring the quality of care. Notably, work stress and resilience are found to be associated with competency of health professionals. However, the role of resilience between work stress and competency remains unexplored.

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Synopsis of recent research by authors named "Yuanmei Lu"

  • - Yuanmei Lu's recent research focuses on the development of novel Proteolysis Targeting Chimera (PROTAC) technology targeting Bruton's Tyrosine Kinase (BTK), which plays a critical role in B-cell malignancies, particularly in lymphomas.
  • - In 2023, Lu highlighted a new BTK PROTAC, described as 6e, which shows enhanced potency in degrading both wild type and C481S mutant BTK proteins, although its metabolic stability remains a challenge for in vivo studies.
  • - Previous work in 2021 emphasized the advantage of PROTACs over traditional irreversible covalent inhibitors, providing a promising alternative in addressing drug resistance associated with mutant BTK in B-cell malignancies.

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