Multiple venous thromboembolisms in a pregnant patient carrying a novel mutation in SERPINC1 (p.M313T) that causes a transient antithrombin deficiency: a case report.

Background: Congenital antithrombin deficiency is an autosomal dominant disease that results in deep venous thrombosis and pulmonary embolism, which is mainly caused by mutations in the antithrombin gene (SERPINC1). Since SERPINC1 is highly susceptible to alterations, severe structural and functional changes that promote thrombosis may occur. Clinical presentations vary from different alterations.

Vascular endothelial growth factor induces the migration of human airway smooth muscle cells by activating the RhoA/ROCK pathway.

Background: Airway remodeling due to increased airway smooth muscle cell (ASMC) mass, likely due to enhanced proliferation, hypertrophy, and migration, has been proven to be highly correlated with decreased lung function in asthma patients. Vascular endothelial growth factor (VEGF) mediates vascular and extravascular remodeling and inflammation and has been proven to be involved in the progression of asthma. Previous studies have focused on the effects of VEGF on ASMC proliferation, but few researchers have focused on the effects of VEGF on human ASMC migration.

Association between platelet counts and clinical outcomes in acute fatty liver of pregnancy: A retrospective cohort study.

Objectives: To investigate whether platelet counts are associated with clinical outcomes in patients with acute fatty liver of pregnancy (AFLP).

Methods: We retrospectively analyzed 140 patients with AFLP admitted to the Third Affiliated Hospital of Guangzhou Medical University between January 2010 and August 2022. In this cohort study, we used smooth curve fitting, Kaplan-Meier analysis, and multivariable logistic regression analysis to examine the independent relationship between platelet counts and 42-day postpartum mortality in AFLP.

Maternal and fetal/neonatal outcomes of pregnancies complicated by pulmonary hypertension: a retrospective study of 154 patients.

Objectives: To determine the main clinical and demographic outcomes related to Pulmonary Hypertension (PH) and adverse obstetric and fetal/neonatal outcomes.

Methods: This study retrospectively analyzed the medical record data of 154 patients with PH who were admitted to the Third Affiliated Hospital of Guangzhou Medical University between January 2011 and December 2020.

Results: According to the severity of elevated Pulmonary Artery Systolic Pressure (PASP), 82 women (53.

Promising Mass-Productive 4-Inch Commercial SERS Sensor with Particle in Micro-Nano Porous Ag/Si/Ag Structure Using in Auxiliary Diagnosis of Early Lung Cancer.

The construction of commercial surface enhanced Raman scattering (SERS) sensors suitable for clinical applications is a pending problem, which is heavily limited by the low production of high-performance SERS bases, because they usually require fine or complicated micro/nano structures. To solve this issue, herein, a promising mass-productive 4-inch ultrasensitive SERS substrate available for early lung cancer diagnosis is proposed, which is designed with a special architecture of particle in micro-nano porous structure. Benefitting from the effective cascaded electric field coupling inside the particle-in-cavity structure and efficient Knudsen diffusion of molecules within the nanohole, the substrate exhibits remarkable SERS performance for gaseous malignancy biomarker, with the limit of detection is 0.

Pregnancy outcomes in women with pulmonary hypertension: a retrospective study in China.

Background: In recent years, with the development of monitoring conditions and the application of pulmonary vascular-targeted drugs, pregnancy outcomes in women with pulmonary hypertension (PH) have improved, but the maternal mortality rate is still high. The purpose of this study was to describe the maternal-foetal outcomes in pregnant women with PH.

Methods: The clinical data of 154 pregnant women with PH who were admitted to the Third Affiliated Hospital of Guangzhou Medical University from January 2011 to December 2020 were collected and descriptively analysed.

Light localization in defective periodic photonic moiré-like lattices.

Photonic moiré-like lattices, a readily accessible platform for realizing the spatial localization of light, attract intensive attention due to their unique flatband characteristics. In this paper, a periodic moiré-like lattice with embedded defects is proposed theoretically, and the linear propagation of the probe beam in such a system is investigated intensively. The results show that the positions of defects in periodic moiré-like lattices depend on the sublattice rotation angle.

Effects of Different Intervention Factors on Vascular Endothelial Growth Factor-Induced Human Airway Smooth Muscle Cell Migration.

Background: Asthma airway remodeling is closely related to the abnormal migration of human airway smooth muscle cells (ASMCs), and vascular endothelial growth factor (VEGF) is involved in the pathophysiological process of asthma. This study aimed to investigate the effect of VEGF on ASMC migration through cell experiments and to intervene in ASMC migration with different asthma drugs and signaling pathway inhibitors to provide a basis for screening effective drugs for airway remodeling.

Methods: The effect of VEGF on the proliferation of ASMCs was detected by the CCK-8 method, and the effect of VEGF on the migration of ASMCs was proven by scratch and transwell assays.

Non-Hermitian mode-locking synthesized by parity-time and anti-parity-time symmetric modulations.

We study the pulse characteristics in a laser mode-locked by active modulators with non-Hermitian driven signals. The signal assembles a parity-time ( ) symmetric and an anti-parity-time ( ) symmetric function with fundamental and harmonic frequencies, respectively, inducing the complex coupling between modes in the frequency domain. A one-dimensional synthetic lattice is used to analyze the spectral mode coupling.

Particle-in-Molybdenum Disulfide-Coated Cavity Structure with a Raman Internal Standard for Sensitive Raman Detection of Water Contaminants from Ions to <300 nm Nanoplastics.

To develop a universal and precise detection strategy that can be applied to water contaminants of various sizes, we designed a particle-in-MoS coated cavity structure of AAO/MoS/Ag with a Raman internal standard. This modified particle-in-cavity structure not only successfully integrates both "surface hot spots" and "volume hot spots" via dressing and manipulating the cascaded optical-field mode inside the cavity but also introduces the chemical enhancement and internal standard attribute of MoS. Because of its unique three-dimensional structure, AAO/MoS/Ag accurately detects water contaminants of various sizes from ions to nanoplastics (<300 nm) for the first time.

Identification of differentially expressed genes and signaling pathways with Candida infection by bioinformatics analysis.

Background: Opportunistic Candida species causes severe infections when the human immune system is weakened, leading to high mortality.

Methods: In our study, bioinformatics analysis was used to study the high-throughput sequencing data of samples infected with four kinds of Candida species. And the hub genes were obtained by statistical analysis.

Precise real-time quantification for photocatalytic reaction: integration of the sensitiveSERS sensor and high-efficiency photocatalyst.

Recently,surface-enhanced Raman spectroscopy (SERS) is gradually becoming an important method for monitoring photocatalytic reaction processes, in which the quantification potential is a vital factor in determining whether this technology can be truly applied in the future. In order to improve the quantification performance ofSERS and explore a precise operando Raman detection for photocatalytic reactions, an architecture of heterostructural CuO/ZnO/Ag nano round brush has been designed and discussed in this work. This structure is an integration of sensitiveSERS sensor and high-efficiency photocatalyst, realizing real-time monitoring of photocatalytic reaction in a wide concentration range from 20 to 3 mg l.

Mo:BiVO Nanoparticles-Based Optical Modulator and Its Application in a 2-μm Pulsed Laser.

Mo:BiVO nanoparticles were employed as an optical modulator in a Q-switched all-solid-state Tm:YAP laser for the first time. The nonlinear optical parameters of Mo:BiVO nanoparticles in the 2-μm region were characterized by measuring nonlinear transmission. Saturation intensity was 718 MW/cm, and the modulation depth was 12.

Broadband and Ultra-Low Threshold Optical Bistability in Guided-Mode Resonance Grating Nanostructures of Quasi-Bound States in the Continuum.

We model optical bistability in all-dielectric guide-mode resonance grating (GMR) nanostructures working at quasi-bound states in the continuum (BICs). The complementary metal-oxide-semiconductor (CMOS) compatible material silicon nitride (SiN) is used for the design of nanostructures and simulations. The ultra-low threshold of input intensity in the feasible nanostructure for nanofabrication is obtained at the level of ~100 W/cm driven by quasi-BICs.

Generation of gradient photonic moiré lattice fields.

We designed and generated gradient photonic moiré lattice fields comprising three varying periodic moiré wavefields. Because of the common twisted angles between periodic triangular and hexagonal moiré wavefields, gradient patterns can be easily obtained through coherent superposition of hexagonal-triangular-hexagonal photonic moiré lattice fields. In addition, two specific twisted angles of Δα| and Δα| are proposed, which not only guarantee the periodicity of moiré fields but also provide an additional degree of freedom to control the structural arrangement of the gradient photonic moiré lattice fields.

Passively Q-Switched Yb:CALGO Laser Based on Mo:BiVO Absorber.

A stable, passively Q-switched Yb:CaGdAlO laser based on Mo:BiVO saturable absorber was demonstrated. Close observations of the structure and morphology of the nanoparticles by using transmission electron microscope, Raman spectrum and linear absorption were measured. The nonlinear transmission of Mo:BiVO was characterized by a 30 ps laser with a central wavelength of 1064 nm and a repetition rate of 10 Hz.

Heterostructured CuO-Au nanowire as a dual-functional nanocomposite for environmental pollutant degradation and hydrogen peroxide sensing.

Materials engineering is generally regarded as one of the most effective methods in the construction of photocatalysts, but it still faces many challenges. In this context, we designed and prepared a three-dimensional (3D) heterostructure of nanowires (NWs) formed by core and an Au shell. The - NWs not only show fine photocatalytic ability but also proved to have Fenton-like chemical properties and can be used as a hydrogen peroxide sensor.

Ultimate conversion efficiency of second harmonic generation in all-dielectric resonators of quasi-BICs in consideration of nonlinear refraction of dielectrics.

We investigate second harmonic generation (SHG) in all-dielectric resonance nanostructures of high-Q factors assisted by quasi-bound states in the continuum (quasi-BICs). The typical resonators, e.g.

miR-145-5p exerts anti-tumor effects in diffuse large B-cell lymphoma by regulating S1PR1/STAT3/AKT pathway.

To investigate the molecular mechanism of miR-145-5p in diffuse large B-cell lymphoma (DLBCL) tissues and cells. The tissues from patients with DLBCL were collected for RT-qPCR or immunohistochemistry. Cell viability, proliferation, migration, invasion, the relationship between miR-145-5p and S1PR1, and proteins related pathway were detected using CCK-8, BrdU staining, Transwell assay, dual luciferase report assay, and western blotting, respectively.

Low let-7d exosomes from pulmonary vascular endothelial cells drive lung pericyte fibrosis through the TGFβRI/FoxM1/Smad/β-catenin pathway.

The pathogenesis of pulmonary fibrosis (PF) was mediated by the progressive deposition of excessive extracellular matrix, but little is known about the regulatory mechanisms of fibrogenesis by lung pericytes. The mouse PF model was established by treatment with bleomycin, followed by isolation of exosomes from mouse broncho-alveolar lavage fluids by the centrifuge method. Relative mRNA/microRNA levels and protein expression were assessed by qRT-PCR and Western blotting, respectively.

Analysis of volume management by comparing between critical care ultrasound examination and pulse indicator cardiac output in patients with septic shock.

Objective: To investigate volume management by comparing between critical care ultrasound examination and pulse indicator cardiac output (PICCO) in patient with septic shock.

Methods: Patients with septic shock during July 2017 and June 2018 were included. Inferior Vena Cava (IVC), total end-diastolic volume index (GEDI), central venous pressure (CVP), lactic acid and oxygenation index were measured by ultrasound.

ZrSe nanosheet as saturable absorber for soliton operations within an Er-doped passive mode-locked fiber laser.

Two-dimensional materials have extensively promoted the development of ultrafast photonics in the past decade. In our work, the saturable absorption properties of were presented. The saturation intensity, modulation depth, and nonlinear absorption coefficient of the saturable absorber (SA) are about 13.

Construction of photorefractive photonic quasicrystal microstructures by twisted square lattices.

A convenient method to fabricate two-dimensional photonic quasicrystal microstructures was experimentally demonstrated by using a rotatable four-wedge prism. Two-dimensional eightfold symmetric quasicrystal microstructures are formed by two groups of twisted square lattices in a photorefractive crystal. The experimental devices of this method are simple and stable without complicated optical adjustment equipment.

Asymmetric localization and symmetric diffraction-free transmission in synthetic photonic lattice with anti-parity-time symmetry.

We study, to the best of our knowledge, the first observations of light propagation in synthetic photonic lattice with anti-parity-time symmetry by tuning the gain or loss of two coupled fiber rings alternatively and corresponding phase distribution periodically. By tuning the phase and the wave number in the lattice, asymmetric transmission of the light field can be achieved for both long and short loops when ≠/2 ( is an integer). Further investigations demonstrate that asymmetric localization of the light field in the long loop and symmetric diffraction-free transmission in two loops can both be realized by changing these two parameters.

Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection.

Objective: To provide clinical management guidelines for novel coronavirus (COVID-19) in pregnancy.

Methods: On February 5, 2020, a multidisciplinary teleconference comprising Chinese physicians and researchers was held and medical management strategies of COVID-19 infection in pregnancy were discussed.

Results: Ten key recommendations were provided for the management of COVID-19 infections in pregnancy.