Dentatacid A: An Unprecedented 2, 3--arbor-2, 3-dioic Triterpenoid from the Invasive Plant , with Cytotoxicity Effect on Colon Cancer.

Michx. is an invasive plant species in China, known for its toxicity and potential to reduce crop yields, posing numerous threats. To gain a deeper understanding of this invasive plant, phytochemical methods were employed to isolate 13 terpenoids (-, , ) and 7 sterols (-) from the ethanol extract of , identifying one new compound and 19 known compounds.

New Meroterpenoids and α-Pyrone Derivatives Isolated from the Mangrove Endophytic Fungal Strain sp. GXNU-Y85.

Two new meroterpenoids, aspergienynes O and P ( and ), one new natural compound, aspergienyne Q (), and a new α-pyrone derivative named 3-(4-methoxy-2-oxo-2H-pyran-6-yl)butanoic acid () were isolated from the mangrove endophytic fungal strain sp. GXNU-Y85, along with five known compounds (-). The absolute configurations of those new isolates were confirmed through extensive analysis using spectroscopic data (HRESIMS, NMR, and ECD).

Chemical constituents of Rubia tibetica Hook. f. from Tibetan medicine and cytotoxic activity evaluation.

Two unprecedented quinone compounds Rubiaxylm A (1) and Rubiaxylm B (2), along with fifteen known anthraquinones (3-17) were isolated and characterized from the roots of Rubia tibetica in Tibetan medicine. Their structures were identified through comprehensive analyses of 1D/2D NMR as well as HR-ESIMS data. Furthermore, all separated compounds were evaluated for their cytotoxic activity on A549, Caco-2, MDA-MB-231 and Skov-3 cell lines.

Structures and Tumor Cell Lines Proliferation Activities of Triterpenes Isolated from Astilbe grandis.

A total of seven compounds, including four triterpene acids and three triterpene lactones, were isolated from the ethanolic extract of the roots of Astilbe grandis Stapf ex Wils. Two of the triterpene lactones (1-2) were never reported before and compounds 3-5 were isolated for the first time from the plant. The structures of these compounds were all identified by spectroscopic analysis.

Brunonianines A-C, C-diterpenoid alkaloids with cyano group from Delphinium brunonianum Royle.

Cyano tends to have better biological activity, but it is rarely reported in natural products, especially in the C-diterpene alkaloids. Herein, three unprecedented C-diterpenoid alkaloids, brunonianines A-C (1-3), possessing rare cyano functional group as well as an atisine backbone constructed from a phenethyl substituent and a tetrahydropyran ring, along with four C-alkaloids (4-7) and one amide alkaloids (8), were isolated from the whole plant of Delphinium brunonianum Royle. Compounds 1-3 are also the first atisine type diterpenoid alkaloids with cyano group obtained from nature.

Triterpenoid acids characterized by the oxidation of the C-27-methy from the roots of Astilbe grandis Stapf ex Wils.

Two unprecedented oleane-type triterpenes (5-6) were isolated from the roots of Astilbe grandis Stapf ex Wils, along with four known triterpenes (1-4), all of which were separated from this plant for the first time. The structures of these compounds were elucidated on the basis of spectroscopic analyses especially analysis of 2D NMR data, and the absolute configurations of 5 and 6 were determined by comparison of experimental and calculated ECD data. The structure of 5 was further confirmed by single crystal X-ray diffraction analysis.