Juvenile toxicity of atropine sulfate eye drops in young rats.

Objectives: This study was to investigate the effects of atropine sulphate eye drops (ASED)on the development of partial systems in young rats and their toxic reactions following repeated eye-drop administration over a period of 40 days.

Methods: SD rats of 20 days old were randomly assigned to control group, 0.01, 0.

Pharmacokinetics of Sirolimus Eye Drops Following Topical Ocular Administration in Rabbits.

To evaluate the pharmacokinetics of sirolimus eye drops following topical instillation in rabbits. The study included 2 experiments. In single-dose pharmacokinetic study, rabbits received a single bilateral instillation of 0.

Immunization with a Prefusion SARS-CoV-2 Spike Protein Vaccine (RBMRNA-176) Protects against Viral Challenge in Mice and Nonhuman Primates.

There is an urgent need for a broad-spectrum and protective vaccine due to the emergence and rapid spreading of more contagious SARS-CoV-2 strains. We report the development of RBMRNA-176, a pseudouridine (Ψ) nucleoside-modified mRNA-LNP vaccine encoding pre-fusion stabilized trimeric SARS-CoV-2 spike protein ectodomain, and evaluate its immunogenicity and protection against virus challenge in mice and nonhuman primates. A prime-boost immunization with RBMRNA-176 at intervals of 21 days resulted in high IgG titers (over 1:819,000 endpoint dilution) and a CD4+ Th1-biased immune response in mice.

Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin.

Introduction: Forsythin is the main ingredient of and is widely used in treatment of fever, viral cold, gonorrhea, and ulcers clinically. This study aimed to evaluate the potential genetic toxicity of forsythin and its safety for human use.

Methods: Based on the Good Laboratory Practice regulations and test guidelines, the genetic toxicity of forsythin was assessed by the Ames test, chromosome aberration (CA) test, and bone marrow micronucleus (MN) test in vivo.

Reproductive Systemic Toxicity and Mechanism of Glucosides of Hook. F. (GTW).

Background: To study the mechanism of reproductive systemic toxicity of on SD rats.

Methods: The SD rats were randomly divided into groups and allocated three different treatments: control, 37.8 mg/kg Tripterygium glycosides, and 94.

Comparative safety assessments of the biosimilar APZ001 and Erbitux in pre-clinical animal models.

Purpose: To evaluate the toxicity of Erbitux as well as its biosimilar APZ001 antibody (APZ001) in pre-clinical animal models including mice, rabbits and cynomolgus monkeys.

Methods: We performed analysis of normal behavior activity, autonomic and non-autonomic nervous functions, nervous-muscle functions, nervous excitability and sensorimotor functions on CD-1 mice. Subsequently, we studied that effects of APZ001 and Erbitux on respiratory system, cardiovascular system and kidney in Cynomolgus monkey models and performed local tolerance experiments on New Zealand rabbits.

[Synthesis of beta-cyclodextrin polymer beads and its behavior of drug release].

Objective: To prepare beta-cyclodextrin polymer (beta-CDP) beads using as a drug carrier and study the release behaviors of Berberine Hydrochlorrde (BH) in beta-CDP beads.

Methods: beta-CDP beads were synthesized by inverse emulsion polymerization. The inclusion complex between beta-CD and BH were investigated by phase solubility method.