Bioaccumulation mechanisms of perfluoroalkyl substances (PFASs) in aquatic environments: Theoretical and experimental insights.

Per- and polyfluoroalkyl substances (PFASs) are persistent, bioaccumulative contaminants found in water resources at levels hazardous to human health. However, the PFAS bioaccumulation mechanism remains poorly understood. In this study, we incorporated density functional theory (DFT), molecular dynamics (MD), and experiments to analyze the partitioning pathways and to establish the structure-bioaccumulation relationship.

A Graph-Theoretical Approach for Tracing Filamentary Structures in Neuronal and Retinal Images.

The aim of this study is about tracing filamentary structures in both neuronal and retinal images. It is often crucial to identify single neurons in neuronal networks, or separate vessel tree structures in retinal blood vessel networks, in applications such as drug screening for neurological disorders or computer-aided diagnosis of diabetic retinopathy. Both tasks are challenging as the same bottleneck issue of filament crossovers is commonly encountered, which essentially hinders the ability of existing systems to conduct large-scale drug screening or practical clinical usage.