Effects of rTMS Intervention on Functional Neuroimaging Activities in Adolescents with Major Depressive Disorder Measured Using Resting-State fMRI.

Repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (L-DLPFC) is commonly used for the clinical treatment of major depressive disorder (MDD). The neuroimaging biomarkers and mechanisms of rTMS are still not completely understood. This study aimed to explore the functional neuroimaging changes induced by rTMS in adolescents with MDD.

Cortical thickness reductions associate with brain network architecture in major depressive disorder.

Background: Cortical thickness reductions in major depressive disorder are distributed across multiple regions. Research has indicated that cortical atrophy is influenced by connectome architecture on a range of neurological and psychiatric diseases. However, whether connectome architecture contributes to changes in cortical thickness in the same manner as it does in depression is unclear.

Disrupted functional networks within white-matter served as neural features in adolescent patients with conduct disorder.

Background: Conduct disorder (CD) has been conceptualized as a psychiatric disorder associated with white-matter (WM) structural abnormalities. Although diffusion tensor imaging could identify WM structural architecture changes, it cannot characterize functional connectivity (FC) within WM. Few studies have focused on disentangling the WM dysfunctions in CD patients by using functional magnetic resonance imaging (fMRI).

Shared and distinct patterns of dynamic functional connectivity variability of thalamo-cortical circuit in bipolar depression and major depressive disorder.

Evidence has indicated abnormalities of thalamo-cortical functional connectivity (FC) in bipolar disorder during a depressive episode (BDD) and major depressive disorder (MDD). However, the dynamic FC (dFC) within this system is poorly understood. We explored the thalamo-cortical dFC pattern by dividing thalamus into 16 subregions and combining with a sliding-window approach.

Bootstrapping a Two-Loop Four-Point Form Factor.

We compute the two-loop four-point form factor of a length-3 half-BPS operator in planar N=4 SYM theory, which belongs to the class of two-loop five-point scattering observables with one off-shell color-singlet leg. A new bootstrapping strategy is developed to obtain this result by starting with an ansatz expanded in terms of master integrals and then solving the master coefficients via various physical constraints. We find that consistency conditions of infrared divergences and collinear limits, together with the cancellation of spurious poles, can fix a significant part of the ansatz.

Silence of p15 expression by RNAi enhances cisplatin resistance in hepatocellular carcinoma cells.

The insensitivity of hepatocellular carcinoma to chemotherapy is associated with alternation in tumor cell cycling. This current study was designed to investigate the impact of p15 silencing on the sensitivity of Human hepatocellular carcinoma HepG2 cells to cisplatin. HepG2/CDDP/1.