Publications by authors named "Yuanhe You"
Tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) widely participate in the malignant progression in cancer. Previously, we have demonstrated that M1-like TAMs cascaded a stem-like phenotype of oral squamous cell carcinoma (OSCC). Yet, the underlying mechanisms still need to be demonstrated for the regulation of TAMs on cancer stem cells (CSCs) in OSCC.
View Article and Find Full Text PDFBackground: This study aimed to investigate potential cellular senescence inhibitory genes (CSIGs) and discover novel therapeutic targets in head and neck squamous cell carcinoma.
Methods: Dysregulated CSIGs were identified based on The Cancer Genome Atlas (TCGA) and the Human Aging Genomic Resources (HAGR) database. Prognostic value and immune infiltration were assessed through bioinformatic analysis.
Article Synopsis
- Neurofibromatosis type 1 (NF1) linked to plexiform neurofibroma (pNF) involves complex interactions between Schwann cells and neurofibroma-associated fibroblasts (NFAFs), which remain unclear.
- Researchers used single-cell RNA sequencing to analyze these interactions and identified the pivotal PTN/NCL signaling pathway that mediates communication between Schwann cells and NFAFs.
- Findings indicate that targeting the PTN/NCL/PRAS40 axis could potentially lead to therapeutic strategies for treating pNF by reducing collagen synthesis and NFAF proliferation.
Article Synopsis
- The study investigates the role of exosome-related genes (ERGs) in head-neck squamous cell cancer (HNSCC), revealing their potential significance in understanding the cancer's immunosuppressive nature.
- Researchers identified two patient subtypes based on ERG expression and developed a risk prediction model using seven genes, linking high-risk patients to poor survival and suppressed immune function.
- Key genes HPRT1 and PYGL were confirmed as independent prognostic factors, associated with immunosuppression and tumor microenvironment alterations in HNSCC, supported by various analyses and immunohistochemistry results.
Article Synopsis
- This study evaluates the role of S100 family genes in head and neck squamous cell carcinoma (HNSCC) to understand their expression patterns and clinical significance.
- Researchers utilized bioinformatics tools and databases like TCGA and Oncomine to analyze gene expression and correlation with patient outcomes.
- Findings suggest that specific S100 family members may serve as prognostic markers and are linked to disease progression, metastasis, and survival rates in HNSCC patients.
Article Synopsis
- Targeted therapy using MEK inhibitors for NF1-related plexiform neurofibroma (pNF) has shown limited success due to other pathways interfering with its effectiveness.
- Previous research indicated that the YAP molecule's increased nuclear activity in NF1-related pNF could play a role in this resistance.
- Combining MEK inhibitor selumetinib with YAP inhibitor verteporfin shows promise in enhancing therapeutic effects, suggesting a dual-targeting approach may be an effective treatment strategy for NF1-related pNF.
Article Synopsis
- Induction chemotherapy in oral squamous cell carcinoma is debated, and a study used single-cell transcriptome analysis to examine cancer cell evolution and tumor environment response post-chemotherapy.
- Key findings identified various cell types, including different subtypes of cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs), based on gene expression patterns.
- The research highlighted elevated inflammatory cytokine levels and enriched molecular pathways linked to epithelial-mesenchymal transition in the tumor microenvironment, offering valuable insights for future studies.
Article Synopsis
- Immunotherapy effectiveness varies among advanced head and neck squamous cell carcinoma (HNSCC) patients, with tumor-infiltrating lymphocytes (TILs) showing unclear roles, leading to a study on TIL-related biomarkers.
- Bioinformatics analysis of TILs used TCGA data to examine gene expression patterns, correlations, and clinical significance in HNSCC patients, revealing key relationships among various immune markers.
- Findings indicated that higher expressions of CD8, CD20, and PD-1 were linked to better overall survival, while CD56 expression had a negative correlation; additionally, HPV status positively correlated with the presence of beneficial TILs.
Article Synopsis
- Tumor-associated macrophages (TAMs) play a significant role in the tumor environment, particularly M1-like TAMs, which are activated by exosomal THBS1 and enhance malignant behaviors in oral squamous cell carcinoma (OSCC).
- Various assays including colony forming, invasion, and in vivo experiments were used to assess how conditioned media (CM) from M1-like TAMs affect OSCC, while mechanisms were explored through advanced molecular techniques like RNA-seq and signaling pathway analysis.
- Results indicated that M1-like TAMs trigger epithelial-mesenchymal transition (EMT) and cancer-stem-like characteristics in OSCC cells by increasing IL6 and activating the Jak/Stat3 pathway, making these factors potential targets for therapy
Article Synopsis
- Undifferentiated pleomorphic sarcoma (UPS) in the oral-maxillary area is uncommon but can progress rapidly to a dangerous stage due to complex anatomical structures.
- The diagnosis relies on histology and immunohistochemistry after ruling out other conditions, and treatments typically follow protocols for oral squamous cell carcinoma.
- The study found a median overall survival of 7.75 months, with some cases showing longer survival following neoadjuvant chemotherapy and identified GBP4 as a potential driver gene along with a mutation in PIK3CA, highlighting new therapeutic avenues.
Article Synopsis
- Plexiform neurofibroma (pNF) is a common and distressing tumor associated with neurofibromatosis type 1 (NF1), particularly in the head and neck region.
- Researchers found that Yes-associated protein (YAP), which is part of the Hippo pathway, plays a significant role in the proliferation of Schwann cells and showed increased nuclear presence in pNF tumors.
- A study using various cell models indicated that YAP inhibitors might be more effective than the traditional MEK1/2 inhibitor selumetinib in targeting Schwann cell activity related to pNF, suggesting the potential importance of the YAP-Hippo pathway in treating this condition.
Genetic landscape of common venous malformations in the head and neck.
J Vasc Surg Venous Lymphat Disord
July 2021
Article Synopsis
- * A total of 300 patients were analyzed, revealing TEK and PIK3CA mutations in 41.3% and 26.7%, respectively, with specific mutations (TEK-L914F and PIK3CA-H1047R) being most prevalent.
- * Retrospective analysis of 649 patients showed that the maxillofacial and oral regions were the most affected by VMs, while targeted sequencing identified TEK mutations in 21.4% of patients
Biological responses of human bone mesenchymal stem cells to Ti and TiZr implant materials.
Clin Implant Dent Relat Res
August 2019
Background: Titanium-zirconium alloy (TiZr1317) is a new material used for biological implants. There are several studies on the effects of TiZr implants on the biological characteristics of human bone mesenchymal stem cells (hBMSCs).
Purpose: The purpose of this study was to investigate the biological responses of hBMSCs to implant holes affected by the physicochemical properties of oral implants (Ti , Ti , TiZr , and TiZr ).