Publications by authors named "Yuanguo Ling"
Article Synopsis
- Glioma is the most prevalent primary brain tumor, known for its aggressive nature and poor patient outcomes, leading to a need for better prognostic tools.
- Researchers employed machine learning and multi-omics approaches to identify key genes such as CENPA, allowing glioma to be classified into three distinct subtypes based on 14 cancer functional states (CFS).
- CENPA was found to have high expression levels and significant roles in glioma cell functions, influencing tumor behavior and outcomes, while its regulation by EZH2 and interaction with the Wnt pathway were also highlighted.
New uses of old drugs hold great promise for clinical translation. Flubendazole, an FDA-approved antiparasitic drug, has been shown to target p53 and promote apoptosis in glioblastoma (GBM) cells. However, its damaging mechanism in GBM remains elusive.
View Article and Find Full Text PDFCausal effect of air pollution on the risk of brain health and potential mediation by gut microbiota.
Ecotoxicol Environ Saf
October 2024
Article Synopsis
- This study investigates the potential causal relationship between four air pollutants (PM2.5, PM10, PM2.5 absorbance, and nitrogen oxides) and various neurological diseases, alongside examining their impact on 1325 brain structures.
- Utilizing Mendelian randomization methods, the research highlights significant associations between air pollution and conditions like stroke, Alzheimer's, epilepsy, and the potential mediating role of gut microbiota, particularly the phylum Lentisphaerae in relation to multiple sclerosis.
- The findings indicate that certain air pollutants maintained significant correlations with specific neurological disorders even after adjusting for other variables, emphasizing the complexity of the interactions between environmental factors and brain health.
Article Synopsis
- Mitochondrial RNA modification (MRM) is key in controlling mitochondrial gene expression and may aid in tumor metastasis, but its role in lower grade gliomas (LGGs) is not well-studied.
- Researchers used single-cell RNA sequencing data to explore MRM-related gene distribution and developed a scoring system using specific algorithms to identify significant MRM-related genes across multiple datasets.
- An analysis revealed that certain MRM genes were upregulated or downregulated in LGGs, with implications for prognosis and treatment response, suggesting that MRM influences the microenvironment to support cancer progression.
Advances in the antitumor mechanisms of tripartite motif-containing protein 3.
J Cancer Res Clin Oncol
February 2024
Article Synopsis
- * This review highlights the mechanisms of TRIM3 in various cancers, summarizing research findings from 1997 to 2023 that explore its impact on tumorigenesis.
- * A deeper understanding of TRIM3 could lead to new strategies for cancer treatment and detection, making it a crucial target for future drug development.
Gliomas are the leading cause in more than 50% of malignant brain tumor cases. Prognoses, recurrences, and mortality are usually poor for gliomas that have malignant features. In gliomas, there are four grades, with grade IV gliomas known as glioblastomas (GBM).
View Article and Find Full Text PDF