The paravertebral lymphatic system is involved in the resorption of the herniated nucleus pulposus and the regression of inflammation associated with disc herniation.

Objective: To investigate the role of the paravertebral lymphatic system in the nucleus pulposus herniation (NPH) resorption and the inflammation regression.

Design: Clinical specimens (n = 10) from patients with lumbar disc herniation (LDH) were collected, C57BL/6 (n = 84) and conditional Vegfr3 knockout mice (n = 14) were used. Immunofluorescence staining detected lymphatic vessels (LVs) and NP cells.

Study on the mechanism of action of Saposhnikovia divaricata and its key phytochemical on rheumatoid arthritis based on network pharmacology and bioinformatics.

Ethnopharmacological Relevance: Saposhnikovia divaricata (Turcz.) Schischk (SD; called "fangfeng" in China) has been widely used in the clinical treatment of rheumatoid arthritis (RA) and has shown well therapeutic effects, but the specific mechanisms of action of its bioactive phytochemicals remain unclear.

Aim Of The Study: This study aimed to investigate the molecular biological mechanism of SD in treating RA through a pharmacology-based strategy.

[Robot-assisted PVP for the treatment of osteoporotic fractures of the upper thoracic vertebra].

Objective: To investigate the clinical effect of "Tianji" orthopedic robot-assisted percutaneous vertebro plasty(PVP) surgery in the treatment of upper thoracic osteoporotic fracture.

Methods: A retrospective analysis was performed on 32 patients with upper thoracic osteoporotic fracture who underwent PVP surgery in Shenzhen Hospital of Traditional Chinese Medicine from August 2016 to June 2022. There were 8 males and 24 females, ranging in age from 58 to 90 years old, with a mean of (67.

Treatment of degenerative lumbar scoliosis using transforaminal lumbar interbody fusion based on the concept of intervertebral correction.

Purpose: The study aimed to examine the outcomes of posterior approach transforaminal lumbar interbody fusion (TLIF) in the treatment of degenerative lumbar scoliosis (DLS) based on the concept of intervertebral correction.

Methods: A retrospective analysis was performed on 76 surgical patients (36 males and 40 females) who underwent posterior TLIF and internal fixation based on the concept of intervertebral correction in Shenzhen Traditional Chinese Medicine Hospital from February 2014 to March 2021.The operation duration, intraoperative blood loss, incision length, and complications were recorded.

[Characterization and osteogenic activity of FSP-modified TiNbTaZr/Zn].

Purpose: To investigate whether Ti-35Nb-2Ta-3Zr/Zn (TNTZ/Zn) composite material processed by friction stir processing has osteogenic activity.

Methods: Zn was added to the surface of TNTZ alloy by friction stir processing. The control group was TNTZ(TNTZ without FSP), the experimental groups was FSP(FSP without Zn), TNTZ/Zn-0.

Appetite Suppression and Interleukin 17 Receptor Signaling Activation of Colonic Mycobiota Dysbiosis Induced by High Temperature and High Humidity Conditions.

It is known that the microbiome affects human physiology, emotion, disease, growth, and development. Most humans exhibit reduced appetites under high temperature and high humidity (HTHH) conditions, and HTHH environments favor fungal growth. Therefore, we hypothesized that the colonic mycobiota may affect the host's appetite under HTHH conditions.

Curcumol Alleviates the Inflammation of Nucleus Pulposus Cells via the PI3K/Akt/NF-κB Signaling Pathway and Delays Intervertebral Disk Degeneration.

Background: Intervertebral disk degeneration (IVDD) is closely associated with inflammatory environments. Curcumol has been shown to alleviate inflammation in various disease models, but its effects on IVDD remain unclear. In this study, we sought to determine the mechanism of curcumol in tumor necrosis factor (TNF)-α-induced nucleus pulposus cells and a mouse IVDD model.

A Review on Design and Mechanical Properties of Additively Manufactured NiTi Implants for Orthopedic Applications.

NiTi alloy has a wide range of applications as a biomaterial due to its high ductility, low corrosion rate, and favorable biocompatibility. Although Young's modulus of NiTi is relatively low, it still needs to be reduced; one of the promising ways is by introducing porous structure. Traditional manufacturing processes, such as casting, can hardly produce complex porous structures.

A novel and injectable strontium-containing hydroxyapatite bone cement for bone substitution: A systematic evaluation.

Reconstruction of bone defects is still a challenge. In this study, we developed and systematically evaluated a novel injectable strontium-containing hydroxyapatite (Sr-HA) bone cement in which Sr-HA powder included 5% Sr and was mixed with a setting liquid that included 5% potassium citrate. This Sr-HA cement was mainly composed of HA and α-tricalcium phosphate (TCP) and exhibited favorable injectability (100%), setting times (the initial setting time was 240 s and the final setting time was 420 s), compressive strength (73.

3D Printing Technologies in Metallic Implants: A Thematic Review on the Techniques and Procedures.

Additive manufacturing (AM) is among the most attractive methods to produce implants, the processes are very swift and it can be precisely controlled to meet patient's requirement since they can be produced in exact shape, dimension, and even texture of different living tissues. Until now, lots of methods have emerged and used in this field with diverse characteristics. This review aims to comprehensively discuss 3D printing (3DP) technologies to manufacture metallic implants, especially on techniques and procedures.

TC4/Ag Metal Matrix Nanocomposites Modified by Friction Stir Processing: Surface Characterization, Antibacterial Property, and Cytotoxicity in Vitro.

Numerous antibacterial biomaterials have been developed, but a majority of them suffer from poor biocompatibility. With the purpose of reducing biomaterial-related infection and cytotoxicity, friction stir processing (FSP) was employed to embed silver nanoparticles (Ag NPs) in a Ti-6Al-4V (TC4) substrate. Characterization using scanning electron microscopy, transmission electron microscopy, and three-dimensional atom probe tomography illustrates that NPs are distributed more homogeneously on the surface of TC4 as the groove depth increases, and silver-rich NPs with a size from 10 to 20 nm exist as metallic silver diffused into the substrate, where the silver content is 4.

[Experimental evaluation of the spraying disinfection efficiency on dental models].

Purpose: To evaluate the disinfect effect after spraying a new kind of disinfectant on the dental plaster models.

Methods: The germ-free plaster samples, which were smeared with bacteria compound including Staphylococcus aureus, Escherichia coli, Saccharomyces albicans, Streptococcus mutans and Actinomyces viscosus were sprayed with disinfectants (CaviCide) and glutaraldehyde individually. In one group(5 minutes later) and another group(15 minutes later), the colonies were counted for statistical analysis after sampling, inoculating, and culturing which were used for evaluation of disinfecting efficiency.

[The effect of different retention pin on the shear force of anterior base plate].

Purpose: The purpose of this study was to compare the effect of enhancement by different shape retention nails on the anterior region resin denture base through shear strength measurements.

Methods: 24 specimens with the same size and thickness were divided into 4 groups by the shape of retention nails. Three experimental groups of the resin denture base specimen were placed a retention nail with different shape, Δtype, V type and I type.

[Fabrication and physical properties of porous individual beta-TCP scaffold to reconstruct residual alveolar ridge in dog].

Purpose: To fabricate porous individual beta-tricalcium phosphate scaffold and test its properties in dog.

Methods: A model of residual alveolar ridge in mandible of a dog was made and CT scanned after 3 months.The data of CT was transformed to 3-D format by MIMICS 7.

[Advances in research and application of beta-tricalcium phosphate, collagen and beta-tricalcium phosphate/collagen composite in bone tissue engineering].

Bone defects in oral and maxillofacial region was a common problem. To repair the defect, bone grafts including autograft, allograft and artificial bone graft were used in clinic despite of their disadvantages. Nowadays, bone tissue engineering has become a commonly used method to repair bone defect.

[Culture and characteristics of porcine dental papilla cells (pDPCs) in vitro].

Purpose: To culture porcine dental papilla cells (pDPCs) and to study the cytobiological characteristics of the cells in vitro.

Methods: Dental papillae were collected from postnatal (1-3 days) pigs, then the pDPCs were isolated and cultured through the method of enzyme-digestion. Vimentin and cytokeratin (CK) were used to demonstrate the cells' mesenchymal derivation.

[Comparison of the cytotoxicity in vitro among six types of nano-silver base inorganic antibacterial agents].

Objective: To evaluate the biocompatibility of nano-silver base inorganic antibacterial agents and compare the cytotoxicity in vitro among six types of nano-silver base inorganic antibacterial agents.

Methods: FUMAT T200-4, HN300, Novaron, Kangwang, MOD and SR1000 were diluted to different concentrations, such as 100 g/L, 50 g/L, 25 g/L and 12.5 g/L.

[The use of computer-aided colorimeter in porcelain-fused-to-metal (PFM) crowns among patients with special colored teeth].

Purpose: To evaluate the roll of ShadeEye-NCC, a computer-aided colorimeter, in Porcelain-Fused-to-Metal crowns among patients with special colored Teeth.

Methods: The first step was to choose the proper patients. The next was to use the colorimeter to measure the base shade of tooth and fabricate the PFM crowns according to the recipe given by the colorimeter.

[In vitro study on the cytotoxicity of strontium substituted hydroxyapatite].

Objective: To evaluate the cytotoxicity of strontium substituted hydroxyapatite.

Methods: Cell Relative Growth Rate(RGR) method, MTT assay and Flow Cytometry(FCM) method were used, and the strontium substituted hydroxyapatite contained different strontium concentration(0%,1%,5%,10%,100%).

Results: It was found that there's no apparent cytotoxicity of all the strontium substituted hydroxyapatite,but the cytotoxicity increased as the strontium concentration raised.