Publications by authors named "Yuanding Liu"
Aptamer-drug conjugates-loaded bacteria for pancreatic cancer synergistic therapy.
Signal Transduct Target Ther
October 2024
Article Synopsis
- * The instability of nucleic acid drugs in the body and the dense stroma of pancreatic tumors hinder effective treatment, but a modified Salmonella strain, VNP20009, may be used to deliver ApDC directly to tumors.
- * The proposed method enhances drug stability and targeting, leading to increased drug concentration at tumor sites, improved bacterial colonization, and better tumor cell death, especially when combining chemotherapy and immunotherapy for a synergistic effect.