Association between kidney stones and poor sleep factors in U.S. adults.

The purpose of our study is to examine the correlation between sleep factors and the prevalence of kidney stones in US adults. A total of 34,679 participants from the National Health and Nutrition Examination Survey 2007 to 2018 were included in the analyses. Sleep data collection included: presleep factors (difficulty falling asleep, sleep onset latency), intra-sleep factors (risk index of obstructive sleep apnea, restless leg syndrome, difficulty maintaining sleep), post-sleep factors (daytime sleepiness, non-restorative sleep), sleep schedule and duration, and sleep quality.

Hyaluronic Acid-Conjugated Fluorescent Probe-Shielded Polydopamine Nanomedicines for Targeted Imaging and Chemotherapy of Bladder Cancer.

Bladder cancer is one of the most common malignancies in the urinary system, with high risk of recurrence and progression. However, the difficulty in detecting small tumor lesions and the lack of selectivity of intravesical treatment seriously affect the prognosis of patients with bladder cancer. In the present work, a nanoparticle-based delivery system with tumor targeting, high biocompatibility, simple preparation, and the ability to synergize imaging and therapy was fabricated.

Sulfhydryl functionalized hyaluronic acid hydrogels attenuate cyclophosphamide-induced bladder injury.

Clinical management of cyclophosphamide (CYP) results in numerous side effects including hemorrhagic cystitis (HC), which is characterized by inflammation and oxidative stress damage. Intravesical hyaluronic acid (HA) supplementation, a therapeutic method to restore barrier function of bladder, avoid the stimulation of metabolic toxicants on bladder and reduce inflammatory response, has shown good results in acute or chronic bladder diseases. However, there are unmet medical needs for the treatment of HC to temporarily restore bladder barrier and reduce inflammation.

Intravesical IR-780 instillation prevents radiation cystitis by protecting urothelial integrity.

Purpose: To explore an efficient preventive strategy for radiation cystitis.

Methods: We instilled IR-780 into the bladders of rats 1 h before bladder irradiation, and its bio-distribution was observed at different times. Bladders were then examined for pathogenic alterations and inflammation levels by day 3 and week 12 postirradiation, and the functional characteristics of the bladder were tested via cystometry by week 12.

Quantitative Diagnosis of TCM Syndrome Types Based on Adaptive Resonant Neural Network.

Artificial intelligence has become one of the most rapidly developing disciplines in the application field of pattern recognition. In target recognition, sometimes, there are multiple identical or similar copies of the target to be recognized in the image, and it is difficult to classify and estimate by traditional methods. In this case, it is necessary to use the SOM network to separate multiple targets and use the multiple order parameters in the improved SNN to pair the target.

Corrigendum: Assessing the Function of the Variant rs1170426 in SLE and the Association Between SLE Drug Target and Susceptibility Genes.

[This corrects the article DOI: 10.3389/fimmu.2021.

Assessing the Function of the Variant rs1170426 in SLE and the Association Between SLE Drug Target and Susceptibility Genes.

A genome-wide association study (GWAS) has discovered that a polymorphism in the gene is associated with systemic lupus erythematosus (SLE). In this study, we explored the candidate function of a variant (rs1170426) in the context of SLE and detected the relationship between SLE susceptible genes and SLE drug target genes. First, we investigated the regulatory role of rs1170426 on expression by expression quantitative trait loci (eQTL) analysis in peripheral blood mononuclear cells (PBMCs), T, B, and monocytes cells and annotated the regulatory function of rs1170426 using bioinformatic databases.