Fighting fire with fire: remodeling Aβ aggregation with H-aggregates of a europium(III) complex.

We herein report a "Fight Aggregation with Aggregation" (FAA) approach for redirection of amyloid-β peptide (Aβ) aggregation using a europium(III) complex (EuL3) that can undergo H-aggregation in aqueous solution under physiological conditions. The H-aggregates of EuL3 may serve as scaffolds that can facilitate the accumulation of Aβ to form non-fibrillar co-assemblies. As a result, the Aβ aggregation-induced cytotoxicity was inhibited.

Recent progress of small-molecule-based theranostic agents in Alzheimer's disease.

Alzheimer's disease (AD) is the most common form of neurodegenerative dementia. As a multifactorial disease, AD involves several etiopathogenic mechanisms, in which multiple pathological factors are interconnected with each other. This complicated and unclear pathogenesis makes AD lack effective diagnosis and treatment.