Publications by authors named "Yuanchun Ye"
Article Synopsis
- Breast cancer remains a leading global health issue, with challenges like relapse and resistance to treatment, prompting research into BYL-719, a PI3 kinase inhibitor, that may target breast cancer stem cells and their microenvironment.
- A 3D mammosphere culture method was utilized to analyze breast cancer stem cells, employing various assays to evaluate cell characteristics and responses to BYL-719.
- Results indicated that BYL-719 effectively inhibited the proliferation and stemness of breast cancer stem cell-like cells in 3D cultures and showed potential in overcoming drug resistance by affecting key cancer-related signaling pathways.
Pancreatic ductal adenocarcinoma (PDAC) is a highly prevalent digestive system malignancy, with a significant impact on public health, especially in the elderly population. The advent of the Human Genome Project has opened new avenues for precision medicine, allowing researchers to explore genetic markers and molecular targets for cancer diagnosis and treatment. Despite significant advances in genomic research, early diagnosis of pancreatic cancer remains elusive due to the lack of highly sensitive and specific markers.
View Article and Find Full Text PDFAging is a major risk factor for cardiovascular diseases. Our previous studies demonstrate that aging impairs the caveolar T-type Ca 3.2-RyR axis for extracellular Ca influx to trigger Ca sparks in vascular smooth muscle cells (VSMCs).
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- - Aging results in reduced height and number of villi and crypts in the small intestine, which diminishes nutrient absorption.
- - The combination of dasatinib and quercetin (D+Q) was tested on elderly mice, showing a reduction in aging markers and increased removal of dying cells in the intestinal villi.
- - D+Q treatment successfully increased the size and number of villi and crypts while also boosting nitric oxide production, indicating its potential to improve intestinal health in older individuals.
Ultra-high-dose-rate radiotherapy, referred to as FLASH therapy, has been demonstrated to reduce the damage of normal tissue as well as inhibiting tumor growth compared with conventional dose-rate radiotherapy. The transient hypoxia may be a vital explanation for sparing the normal tissue. The heterogeneity of oxygen distribution for different doses and dose rates in the different radiotherapy schemes are analyzed.
View Article and Find Full Text PDFCellular metabolism modulates effector functions in human CD4 T (Th) cells by providing energy and building blocks. Conversely, cellular metabolic responses are modulated by various influences, e.g.
View Article and Find Full Text PDFThe novel long non-coding RNA (lncRNA) LINC01094 is often upregulated in renal cell carcinoma and glioma; however, its role in gastric cancer remains unclear. Here, we aim to demonstrate the relationship between LINC01094 and gastric cancer. The gene expression (RNASeq) data of 375 patients with localized, locally advanced, and metastatic gastric cancer were extracted from The Cancer Genome Atlas.
View Article and Find Full Text PDFDuring DNA repair, BRCA1 and BRCA2 interact with the tumor suppressor partner and localizer of BRCA2 (PALB2). PALB2 mutations are associated with an increased risk of breast and ovarian carcinoma, and upregulated PALB2 expression is associated with poor clinical outcomes. The present study investigated the role and prognostic value of PALB2 in pancreatic ductal adenocarcinoma (PDAC).
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- * Researchers analyzed data from 127 patients who either had 3D-LPN or traditional LPN, finding no significant differences in demographics and major outcomes.
- * However, patients with higher RENAL scores (≥8) who underwent 3D-LPN experienced shorter warm ischemia times and less blood loss, suggesting that 3D modeling may enhance surgical planning for complex cases.