Publications by authors named "YuanFeng Yang"
Article Synopsis
- Belamcanda chinensis (BC) and Iris tectorum Maxim. (ITM) are both used for treating sore throat, cough, and asthma but are often confused due to their similar appearance, necessitating a study to distinguish between them.
- The study aimed to compare BC and ITM in terms of appearance, chemical makeup, biological effects, pharmacokinetics, and tissue distribution using advanced methods.
- Results indicated that while both plant extracts contain similar isoflavones, ITM demonstrated stronger anti-inflammatory and inhibitory effects on certain biological activities compared to BC, highlighting the need for careful differentiation in medicinal use.
Article Synopsis
- Anastomotic leakage (AL) is a significant postoperative complication in colorectal cancer surgeries, prompting a study to compare the modified double-stapling technique (MDST) with the conventional double-stapling technique (DST).
- In this study of 232 patients, those undergoing MDST experienced a significantly lower rate of AL (3.4%) compared to those who had DST (11.2%).
- The findings suggest that MDST may be a more effective surgical approach for patients with middle and high rectal cancer, as it reduces the risk of complications associated with ischemic "dog-ears" created during the procedure.
Cross-Domain Traffic Scene Understanding by Integrating Deep Learning and Topic Model.
Comput Intell Neurosci
March 2022
Understanding cross-domain traffic scenarios from multicamera surveillance network is important for environmental perception. Most of existing methods select the source domain which is most similar to the target domain by comparing entire domains for cross-domain similarity and then transferring the motion model learned in the source domain to the target domain. The cross-domain similarity between overall different scenarios with similar local layouts is usually not utilized to improve any automatic surveillance tasks.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed the effectiveness of three different laparoscopic intersphincteric resection (LAISR) approaches for treating low rectal cancer in 235 patients between 2010 and 2016.
- Results indicated that the transanal pull-through (PAISR) and transabdominal (TAISR) approaches had shorter operation times and less blood loss compared to the transabdominal perineal approach (TPAISR).
- All approaches were found to have similar safety and outcome rates, but TPAISR took longer and had more complications, so PAISR is recommended when certain patient conditions are met, otherwise TPAISR is preferred.
Article Synopsis
- - The study evaluates how the distribution of lymph node metastasis (LND) impacts outcomes in patients with locally advanced rectal cancer (LARC) following neoadjuvant chemoradiotherapy (nCRT), involving 179 patients classified into three groups based on their LND.
- - Findings indicate that LND significantly predicts 3-year disease-free survival (DFS), local recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS), outperforming existing staging systems like ypN and ypTNM.
- - LND is identified as an independent prognostic factor, suggesting it can serve as an additional tool alongside the ypTNM staging system to better assess outcomes for stage III rectal cancer patients post
Background: There are only limited studies on the long non-coding RNAs (lncRNAs) associated with neoadjuvant chemoradiotherapy (NCRT) response and prognosis of locally advanced rectal cancer (LARC) patients. This study identified lncRNAs associated with NCRT response and prognosis in CRC patients and explored their potential predictive mechanisms.
Methods: The study subjected the LncRNA expression profiles from our previous gene chip data to LASSO and identified a four-lncRNA signature that predicted NCRT response and prognosis.
Purpose: To evaluate the impact of the log odds of positive lymph nodes (LODDS) on cancer-specific survival (CSS) in colon mucinous adenocarcinoma (MAC) patients, compared with pN stage and the lymph nodes ratio (LNR).
Methods: A total of 10,182 colon MAC patients from the Surveillance, Epidemiology, and End Results database were divided into the training group. The external validation group included 153 patients from Fujian Medical University Union Hospital.
Article Synopsis
- D3 or complete mesocolic excision surgery is common for treating colon cancer metastasis, but there's a need for better guidelines on lymph node dissection for T3 and T4 stage right colon cancer.
- A study categorized patients by tumor location and analyzed lymph node metastasis distribution, revealing that the highest metastasis incidence occurs in the paracolic area.
- The findings suggest that for T3/T4 hepatic flexure cancer, radical right hemicolectomy and dissection of No.206 lymph nodes are essential for effective treatment.
Background: To identify the hub genes associated with chemoradiotherapy resistance in rectal cancer and explore the potential mechanism.
Methods: Weighted gene co-expression network analysis (WGCNA) was performed to identify the gene modules correlated with the chemoradiotherapy resistance of rectal cancer.
Results: The mRNA expression of 31 rectal cancer patients receiving preoperative chemoradiotherapy was described in our previous study.
Article Synopsis
- The study focused on the risk factors for lymph node metastasis (LNM) in well-differentiated rectal neuroendocrine tumors (RNETs) by analyzing data from 223 patients across multiple hospitals.
- Independent risk factors identified for LNM included tumor size, the World Health Organization (WHO) grade, and the depth of tumor invasion, with a high predictive accuracy for LNM risk.
- A recursive partitioning analysis (RPA) model was developed, showing a significant difference in LNM incidence between low-risk (1.1%) and high-risk (56.4%) patient groups, aiding in treatment decisions for local resection.
Article Synopsis
- Gastrointestinal motility disorders (GMD) impact daily life globally, with limited effective treatments in Western medicine, while Fructus aurantii (FA), a traditional Chinese herbal remedy, has been used for centuries to remedy GMD.
- This study aimed to evaluate the efficacy of different FA fractions on normal mice and GMD rats to identify the most effective components through advanced statistical analysis.
- The findings revealed that the ethyl acetate fraction of FA is the most active, containing nine key compounds that regulate gastrointestinal function, and the developed analysis methods can reliably screen for bioactive components in natural products.
The aim of this study was to explore the role of sulfasalazine on proliferation and metastasis in gastric cancer by inhibition of xCT. The relationships between clinical characteristics and xCT expression were analysed. An immunohistochemical staining assay and Western blot were performed among gastric cancers and normal gastric tissues.
View Article and Find Full Text PDFPurpose: To assess the value of macrophage-related biomarkers (CD163, CD68, MCSF, and CCL2) for predicting the response to neo-chemoradiotherapy (NCRT) and the prognosis of locally advanced rectal cancer (LARC).
Methods: We enrolled 191 patients who underwent neoadjuvant chemoradiotherapy and radical resection between 2011 and 2015. Tumor tissues were collected before NCRT with a colonoscope and post-surgery and were subjected to immunohistochemical analysis.
Ferroptosis is a form of iron-dependent programmed cell death. Regulation of ferroptosis in tumor cells is a novel treatment modality. The present study aimed to investigate ferroptosis-related long non-coding RNAs (lncRNAs) and construct a prognostic model for colon adenocarcinoma (COAD).
View Article and Find Full Text PDFObjective: GRWD1 (glutamate-rich WD40 repeat containing 1) is a multifunctional protein involved in multiple cellular regulatory pathways, particularly those associated with cell growth control. GRWD1 is represented as a potential oncogene in several cancers, however, the function and mechanism of GRWD1 in the development of colon cancer are still unknown.
Materials And Methods: IHC was used to detect the expression of GRWD1 in colon carcinoma tissues.
Purpose: To assess the role of the expression levels of FOXK family members, FOXK1 and FOXK2, in predicting response to neo-chemoradiotherapy (NCRT) and prognosis in locally advanced rectal cancer (LARC).
Methods: A total of 256 LARC patients who underwent NCRT and radical resection between 2011 and 2017 were enrolled in the present study. The patients were divided into a training dataset (n=169, 2011-2015) and a validation dataset (n=87, 2016-2017).
To determine the efficacy of neoadjuvant chemoradiotherapy (NCRT) between young and old patients with locally advanced rectal cancer (LARC) in terms of tumor response and survival outcome.LARC patients undergoing NCRT and radical surgery from 2011 to 2015 were included and divided into: young (aged ≤50 years) and old group (aged >50 years). Multivariate analyses were performed to identify risk factors for local recurrence.
View Article and Find Full Text PDFPurpose: Hypoxia-inducible factor 2α (HIF-2α) overexpression leads to activation of angiogenic pathways. However, little is known about the association between HIF-2α expression and anti-tumor immunity in clear cell renal cell carcinoma (ccRCC). We aimed to explore how HIF-2α influenced the microenvironment and the underlying mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the galvanic corrosion of three metal alloys (aluminum-brass, titanium alloy, and 316L stainless steel) used in water desalination plants by using multielectrode arrays.
- It finds that the corrosion behavior varies based on chloride ion concentration, with aluminum-brass being more susceptible to corrosion compared to the other two alloys, particularly at 2.3 wt % chloride.
- The arrangement of the electrodes affects the corrosion rates, with the worst corrosion occurring when aluminum-brass wires are positioned between the titanium and stainless steel wires.
The local electrochemical properties of galvanic corrosion for three coupled metals in a desalination plant were investigated with three wire-beam electrodes as wire sensors: aluminum brass (HAl77-2), titanium (TA2), and 316L stainless steel (316L SS). These electrodes were used with artificial seawater at different temperatures. The potential and current-density distributions of the three-metal coupled system are inhomogeneous.
View Article and Find Full Text PDFPurpose: CXCR1 signaling promotes tumor progression in various cancers, and clinical trial has proved efficacy of CXCR1 inhibitor in metastatic breast cancer. Therefore, we investigated the prognostic value of CXCR1 in patients with metastatic renal cell carcinoma (mRCC) receiving tyrosine kinase inhibitors (TKIs) therapy.
Materials And Methods: Patients treated with sunitinib or sorafenib were retrospectively enrolled (n = 111).
Background And Purpose: Some of the fucosylation catalyzed by fucosyltransferase-III mediates the epithelial-mesenchymal transition and enhances tumor cell-macrophage signaling, which promotes malignant transforming and immune evasion. The aim of the study was to investigate the association between the expression of fucosyltransferase-III and clinical outcomes of patients with clear-cell renal cell carcinoma after surgery.
Results: High fucosyltransferase-III expression was associated with a greater risk of recurrence ( = 0.
Purpose: Accumulating evidence indicates that CXC chemokine receptor 6 (CXCR6) has a crucial role in cancer development and progression, however, its role in clear cell renal cell carcinoma (ccRCC) remains obscure. The aim of this study is to investigate the prognostic value of CXCR6 expression in patients with ccRCC following surgery.
Materials And Methods: This study retrospectively included 239 patients with ccRCC who underwent nephrectomy and had paraffin tissue available at a single center.
Beta-1,4-galactosyltransferase II is found to be associated with the alterations of tumor-related glycosylation. However, the clinical significance of beta-1,4-galactosyltransferase II in non-metastatic clear-cell renal cell carcinoma has not been reported up to now. Herein, our researches suggested that the expression level of beta-1,4-galactosyltransferase II was first found to be positively associated with tumor size, Fuhrman grade, lymphovascular invasion, rhabdoid differentiation, tumor necrosis and poor overall survival and recurrence-free survival of patients with non-metastatic clear-cell renal cell carcinoma, both in training set and validation set.
View Article and Find Full Text PDFBackground: Mucin13 (MUC13) is a transmembrane glycoprotein that is aberrantly expressed in ovarian and gastro-intestinal tumors, but its role in renal cell carcinoma remains elusive. The purpose of this study is to evaluate the prognostic value of MUC13 expression in patients with non-metastatic clear cell renal cell carcinoma (ccRCC) after surgical resection.
Results: MUC13 high expression was associated with high Fuhrman grade (p < 0.