Valence Fluctuation of Uranium Ions in Uranium Sesquinitride Revealed by Dynamical Mean-field Theory Merged with Density Functional Theory.

The electronic properties, in particular, the occupation number of 5f electrons and the valence state of U ions in uranium sesquinitride (U N ) are studied by using density functional theory (DFT) calculations merged with dynamical mean-field theory (DMFT). The results demonstrate that j=5/2 and j=7/2 manifolds are in the weakly correlated metallic and weakly correlated insulating regimes, respectively. The quasi-particle weights indicate that LS coupling scheme is more feasible for 5f electrons, which are not in the orbital-selective localized state.

Attenuation of renal injury by depleting cDC1 and by repurposing Flt3 inhibitor in anti-GBM disease.

Previous studies found cDC1s to be protective in early stage anti-GBM disease through Tregs, but pathogenic in late stage Adriamycin nephropathy through CD8 T cells. Flt3 ligand is a growth factor essential for cDC1 development and Flt3 inhibitors are currently used for cancer treatment. We conducted this study to clarify the role and mechanisms of effects of cDC1s at different time points in anti-GBM disease.

[MicroRNA-125b regulates osteogenic differentiation of human periodontal ligament stem cells].

Purpose: To investigate the effect of microRNA-125b (miR-125b) on osteogenic differentiation of periodontal ligament stem cell (PDLSCs).

Methods: The surface factor of isolated PDLSCs was detected by flow cytometry. After transfected with miR-125b or anti-miR125b in PDLSCs, MTT and LDH were used to detect cell viability and cytotoxicity; ALP activity and calcium level were detected by ALP assay kit and calcium colorimetric assay kit.

[SiRNA silencing Rsk2 gene expression inhibits proliferation and osteogenic differentiation of human periodontal ligament cells].

Purpose: To study the effect of ribosomal S6 kinase (Rsk2) gene on proliferation and osteogenic differentiation of human periodontal ligament cells (hPDLCs) and underlying mechanism.

Methods: Premolar surgically extracted were collected, the periodontal ligament was separated and hPDLCs were primarily cultured. Cells of 4 to 6 passage were used in the experiment.

A first principles study of the thermal stability of A(m)(MH(4))(n) light complex hydrides.

From the physical point of view, the cohesive energy of a reactant is preferable to its formation energy for characterizing its influence on the reaction processes from the reactants to the products. In fact it has been found that there is a certain correlation between the experimental hydrogen desorption temperature and the cohesive energy calculated by a first principles method for a series of A(m)(MH(4))(n) (A = Li, Na, Mg; M = Be, B, Al) light complex hydrides (including Na(2)BeH(4), Li(2)BeH(4), NaAlH(4), LiAlH(4), Mg(AlH(4))(2), LiBH(4) and NaBH(4)), which suggests that cohesive energy may be a useful physical quantity for evaluating the hydrogen desorption ability of complex hydrides, especially in cases when dehydrogenation products have unknown crystal structures, or may even be unknown. To understand this correlation more deeply, the ionic interaction between A and the MH(4) complex and the covalent interaction between M and H were calculated and their contributions to the cohesive energy evaluated quantitatively.

A clinical evaluation of serological diagnosis for pancreatic cancer.

AIM:To assess the diagnostic values of tumor markers for pancreatic cancer.METHODS:Pancreatic cancer-associated antigen from colonic mucosa (PCAAc), pancreas-specific antigen (PaA), pancreatic oncofetal antigen (POA) and minimolecular pancreatic antigen (mPOA) were detected by double antibodies Sandwich ELISA; CA19-9,elastase 1 (E1), human pancreatic elastase 1 (HPE1) and carcinoembryonic antigen (CEA) by radioimmunoassay (RIA); general activities of ribo-nuclease (RNase) and its isoenzymes (RNase I and RNase I) by biochemistry and PAEG;glycylproline dipeptidyl aminopeptidase (GPDA) by biochemistry andalpha 1-antitrypsin (alpha1AT) by rocket immunoelectrophoresis (rocket-IE).RESULTS:The detection of serum POA,mPOA,PaA,PCAAc,CA19-9,RNase and RNase I was able to differentiate pancreatic cancer from the benign disorders and non-pancreatic malignancies with a sensitivity from 66.