Vitro UPLC analysis and mass method identification, and in vivo or cellular immune anti-inflammatory function of Sanhuang Xiexin Decoction (SHXD).

Ethnopharmacological Relevance: Sanhuang Xiexin Decoction (SHXD), consisting of Coptis chinensis Franch., Scutellaria baicalensis Georgi and Rheum palmatum L., is traditionally used for relieving fever, purging fire for removing toxins, eliminating phlegm and haemostasis, eliminating the wetness-evil from the upper warmer, clearing away the heat-evil and expelling superficial evils.

A Bibliometric Analysis of Heart Failure with Preserved Ejection Fraction From 2000 to 2021.

Heart Failure with preserved Ejection Fraction (HFpEF) is a heterogeneous disease, which is becoming a worldwide menace. By retrieving the relevant literature of HFpEF from 2000 to 2021, qualitative and quantitative evaluations are carried out to visualize the scientific achievements in this field. The data were from the Web of Science Core Collection database.

Coronary Heart Disease and Depression or Anxiety: A Bibliometric Analysis.

This study aimed to conduct a bibliometric analysis of published studies on the association between coronary heart disease (CHD) and depression or anxiety. The study also aimed to identify leading authors, institutions, and countries to determine research hotspots and obtain some hints from the speculated future frontiers. Publications about CHD and depression or anxiety between 2004 and 2020 were collected from the Web of Science Core Collection (WOSCC) database.

Network Pharmacology Analysis of the Therapeutic Mechanisms Underlying Beimu-Gualou Formula Activity against Bronchiectasis with Molecular Docking Validation.

Background: The classical Chinese herbal prescription Beimu-Gualou formula (BMGLF) has been diffusely applied to the treatment of respiratory diseases, including bronchiectasis. Although concerning bronchiectasis the effects and mechanisms of action of the BMGLF constituents have been partially elucidated, it remains to be determined how the formula in its entirety exerts therapeutic effects.

Methods: In this study, the multitarget mechanisms of BMGLF against bronchiectasis were predicted with network pharmacology analysis.

Prospective multicenter clinical trial of Chinese herbal formula JZQG (Jiangzhuoqinggan) for hypertension.

A prospective multicenter clinical trial was conducted to compare the beneficial effects of a Chinese herbal medicine formula Jiangzhuoqinggan (JZQG) and western antihypertension drug irbesartan. JZQG is mainly composed of rhubarb, coptis, cassia, and uncaria. A total of 240 patients with mild to moderate hypertension were enrolled in the trial.

[Serum proteomic study on hypertension patients with Gan-Dan damp-heat syndrome].

Objective: To study the serum proteomics in hypertension patients with Gan-Dan damp-heat syndrome (GDDH) for tentatively find special proteins associated with the syndrome.

Methods: Study was performed in 60 hypertensive patients and 39 healthy persons as control. In the patients enrolled, 40 were differentiated as GDDH syndrome and the other 20 as non-GDDH syndrome.

[Relationship between Chinese medicine syndrome and peripheral blood stem cells in patients with ischemic heart failure].

Objective: To explore the relationship of Chinese medicine syndromes with heart function and peripheral blood stem cells (PBSCs) count in patients with ischemic heart failure (IHF).

Methods: Clinical materials of 208 inpatients with IHF were collected and the characteristics of their Chinese medicine syndromes were summarized, the number of PBSC was counted with flow cytometer, and the differences of left ventricular ejection fraction (LVEF), N-terminal brain natriuretic peptide (NT-proBNP) and PBSC count related to various syndrome factors and syndrome types were compared using One-way ANOVA.

Results: LVEF >50% was found in patients with syndromes of qi-deficiency, yin-deficiency, turbid-phlegm and blood-stasis, while <50% in those of yang-deficiency and fluid-retention, showing significant differences between the former four syndromes and the latter two syndromes.

[Association between the number of peripheral blood stem cells and cardiac function index in patients with ischemic heart failure].

Objective: To observe the association between the number of peripheral blood stem cells (PBSC) and cardiac function index (NYHA grade, left ventricular ejection fraction, LVEF, N-terminal-proB-type Natriuretic Peptide, NT-pro BNP) in patients with ischemic heart failure (IHF).

Methods: A total of 199 patients hospitalized in our department between August 2007 and April 2008 due to IHF were included in this study. NYHA grade, LVEF (measured by echocardiography), plasma NT-proBNP and number of PBSC were analyzed.

Serum proteomes of hypertension patients with abundant phlegm-dampness.

Objective: To study the serum proteomes of essential hypertension (EH) patients with abundant phlegm-dampness, and try to find special proteins associated with abundant phlegm-dampness syndrome.

Methods: Fifty-nine hypertension patients were included, and the patients were divided into abundant phlegm-dampness syndrome group (39 cases) and non-phlegm-dampness syndrome group (20 cases). To find the special proteins associated with abundant phlegm-dampness, the EH patients with non-phlegm-dampness and another 30 healthy persons were regarded as control.

[Influence of shenfu injection on heart function and bone marrow stem cell mobilization in patients with chronic heart failure of coronary heart disease].

Objective: To explore the influence of Shenfu Injection (SFI) on heart function and bone marrow stem cell mobilization in patients with chronic heart failure.

Methods: Sixty-three patients of coronary heart disease (CHD) with chronic heart failure were randomly assigned to the control group (32 cases) and the treatment group (31 cases). Western medical conventional treatment was given to all patients, but SFI was given once a day to patients in the treatment group additionally at the dose of 40 mL by dripping after dilution.

[Relationship between plasma protein expression profiles and states of Zang-Fu organs in patients with phlegm or blood stagnation syndromes due to hyperlipidemia and atherosclerosis].

Objective: To investigate the relationship between the plasma biomarker proteins and the states of Zang-Fu organs in patients with phlegm or blood stagnation syndromes due to hyperlipidemia and atherosclerosis.

Methods: The states of Zang-Fu organs in 146 patients with hyperlipidemia and atherosclerosis were diagnosed by syndrome differentiation of traditional Chinese medicine. The plasma proteins from these patients were separated by two-dimensional polyacrylamide gel electrophoresis (2-DE).