[Bioinformatics and animal experiments reveal mechanism of Linggui Zhugan Decoction in ameliorating chronic heart failure after myocardial infarction via HIF-1α/HO-1 signaling pathway].

This study aims to investigate the effect of Linggui Zhugan Decoction(LGZGD) on autophagy in the mouse model of chronic heart failure(CHF) induced by myocardial infarction(MI), as well as the regulatory effect of LGZGD on the hypoxia-inducible factor-1α(HIF-1α)/heme oxygenase-1(HO-1) signaling pathway, based on bioinformatics and animal experiments. The active ingredients and corresponding targets of LGZGD were retrieved from the Traditional Chinese Medicine Systems Pharmacology and Analysis Database, and GEO, GeneCards, and DisGeNET were searched for the disease targets. Cytoscape was used to establish a "drug-component-target" network.

[Effects of reduced nitrogen application on yield, nitrogen utilization of spring maize and soil nitrate content in Weibei dryland, Northwest China].

To get a scientific pattern for nitrogen-reducing and efficiency-increasing production of spring maize in Weibei dryland, we conducted an field experiment of spring maize (Zhengdan 958 and Shaandan 8806) under dryland farming from 2016 to 2019 in Heyang County, located in Weibei dryland of Shaanxi. There were five nitrogen (N) treatments, including 360 kg·hm(N, a rate commonly adopted by local farm households), 270 kg·hm(N), 150-180 kg·hm(N), 75-90 kg·hm(N) and 0 kg·hm(N). We investigated the effects of reduced nitrogen application on maize yield, nitrogen uptake and utilization of spring maize and soil nitrate residue.

[Effects of tillage alternation pattern with subsoiling on soil physical and chemical properties and spring maize yield in the Loess Plateau, China].

Straw mulching and subsoiling can protect soil and improve soil structure. However, long-term continuous subsoiling cannot continuously gain yield increasing and soil improvement. To realize continuous soil improvement and yield enhancement, a long-term experiment on subsoiling alternation patterns was carried out with spring maize continuous cropping in the Loess Plateau in 2007-2016.

Cell Membrane Capsules for Encapsulation of Chemotherapeutic and Cancer Cell Targeting in Vivo.

Systemic administration of chemotherapeutic agents can cause indiscriminate drug distribution and severe toxicity. Until now, encapsulation and targeting of drugs have typically relied on synthetic vehicles, which cannot minimize the clearance by the renal system and may also increase the risk of chemical side effects. Cell membrane capsules (CMCs) provide a generic and far more natural approach to the challenges of drug encapsulation and delivery in vivo.