Publications by authors named "Yuan-Zhen Gao"
Article Synopsis
- ROS from UV radiation can cause significant damage to skin cells, contributing to aging, but the exact process isn't fully understood.
- Researchers created a model to study this damage using UVA irradiation on skin cells and explored how the compound liquiritigenin (LQ) might protect against these effects.
- Findings suggest that LQ helps reduce oxidative stress, boosts energy production, and promotes skin cell growth and collagen synthesis, offering a potential strategy for reversing skin aging.
The broad-spectrum anticancer drug doxorubicin (Dox) is associated with a high incidence of cardiotoxicity, which severely affects the clinical application of the drug and patients' quality of life. Here, we assess how Dox modulates myocardial energy and contractile function and this could aid the development of relevant protective drugs. Mice were subjected to doxorubicin and breviscapine treatment.
View Article and Find Full Text PDFHeart aging is the main susceptible factor to coronary heart disease and significantly increases the risk of heart failure, especially when the aging heart is suffering from ischemia-reperfusion injury. Numerous studies with NAD+ supplementations have suggested its use in anti-aging treatment. However, systematic reviews regarding the overall role of NAD+ in cardiac aging are scarce.
View Article and Find Full Text PDFDoxorubicin (Dox) is an effective chemotherapeutic drug for the treatment of various cancers. Due to its potential fatal cardiotoxic side effects, the clinical application is often limited. Dexrazoxane (Dex) is the only drug approved by the Food and Drug Administration (FDA) for the prevention of Dox-induced cardiotoxicity but has side effects.
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