Small-molecule exhibits anti-tumor activity by targeting the RNA mA reader IGF2BP3 in ovarian cancer.

Based on its absence in normal tissues and its role in tumorigenesis and tumor progression, insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), a reader of N6-methyladenosine (MA) on RNA, represents a putative valuable and specific target for some cancer therapy. In this study, we performed bioinformatic analysis and immunohistochemistry (IHC) to find that IGF2BP3 was highly expressed in tumor epithelial cells and fibroblasts of ovarian cancer (OC), and was associated with poor prognosis, metastasis, and chemosensitivity in OC patients. In particular, we discovered that knockdown IGF2BP3 expression inhibited the malignant phenotype of OC cell lines by decreasing the protein levels of c-MYC, VEGF, CDK2, CDK6, and STAT1.

Molecular characterization and immune efficacy of fructose-1,6-bisphosphate aldolase from Haemaphysalis longicornis (Acari: Ixodidae).

Background: Ticks are obligate hematophagous ectoparasites that transmit a variety of pathogens to humans, wildlife and domestic animals. Vaccination is an effective and environmentally friendly method for tick control. Fructose-1,6-bisphosphate aldolase (FBA) is an important glycometabolism enzyme that is a candidate vaccine against parasites.

Ferroelectric artificial synapse for neuromorphic computing and flexible applications.

Research of artificial synapses is increasing in popularity with the development of bioelectronics and the appearance of wearable devices. Because the high-temperature treatment process of inorganic materials is not compatible with flexible substrates, organic ferroelectric materials that are easier to process have emerged as alternatives. An organic synaptic device based on P(VDF-TrFE) was prepared in this study.

Increased Urinary CD163 Levels in Systemic Vasculitis with Renal Involvement.

Objectives: Systemic vasculitis includes a group of disorders characterized by inflammation of the vessel wall, involving multiple systems, and can cause malignant hypertension. CD163 is a specific marker of anti-inflammatory macrophages. This study is aimed at evaluating the CD163 levels in relation to systemic vasculitis and renal involvements.

SPOCK1 promotes the proliferation and migration of colon cancer cells by regulating the NF-κB pathway and inducing EMT.

Sparc/osteonectin, cwcv, and kazal-like domains proteoglycan 1 (SPOCK1) has been shown to promote various tumors, but its role in colon cancer (CRC) has not been clearly illuminated. The aim of this study was to investigate the effects of SPOCK1 interference on the proliferation, migration, and EMT of CRC cells. First, we analyzed the expression of SPOCK1 in various CRC datasets.

aqueous extract attenuates isoproterenol-induced cardiac hypertrophy through the ERK signalling pathway.

Context: The pharmacological functions of Wall. ex Lindl. (Orchidaceae) in cardiac hypertrophy remains unclear.

Huntingtin-associated protein 1 plays an essential role in the pathogenesis of type 2 diabetes by regulating the translocation of GLUT4 in mouse adipocytes.

Objective: Glucose disposal by insulin-responsive tissues maintains the body glucose homeostasis and insulin resistance leads to a risk of developing type 2 diabetes (T2DM). Insulin stimulates the translocation of glucose transporter isoform 4 (GLUT4) vesicles from intracellular compartments to the plasma membrane to facilitate glucose uptake. However, the underlying mechanisms of GLUT4 vesicle translocation are not well defined.

Evaluating the implementation of rapid diagnostic tests in a malaria elimination setting.

Background: It was recommended that malaria rapid diagnostic tests (RDTs) should be available in all epidemiological situations. But evidence was limited on the implementation of RDTs and its effectiveness in malaria elimination settings. This study examined the implementation of RDTs and how it affected the diagnosis of imported malaria patients in Jiangsu Province, China.

Regulatory effects of Prohibitin 1 on proliferation and apoptosis of pulmonary arterial smooth muscle cells in monocrotaline-induced PAH rats.

Background: Pulmonary arterial hypertension (PAH) is a severe pulmonary vascular disease characterized by unbalanced proliferation and apoptosis of pulmonary arterial smooth muscle cells (PASMCs). Prohibitin 1 (PHB1) is known for its significant anti-proliferative activity. However, the role of PHB1 in PASMCs and PAH have not been elucidated.

Cost-effectiveness analysis of malaria rapid diagnostic tests: a systematic review.

Background: Rapid diagnostic tests (RDT) can effectively manage malaria cases and reduce excess costs brought by misdiagnosis. However, few studies have evaluated the economic value of this technology. The purpose of this study is to systematically review the economic value of RDT in malaria diagnosis.

[Effect of Huntingtin-associated Protein 1 Gene on Proliferation of Mouse Fibroblasts].

Objective: To determine the effect of Huntingtin-associated protein 1 ( 1) on fibroblast proliferation.

Methods: 1 knockout ( 1 ) primary fibroblasts were isolated and cultured . The proliferation of 1 fibroblasts was detected by EdU proliferation assay and cell flow assay.

[Epidemiological analysis of malaria prevalence in Jiangsu Province in 2017].

Objective: To understand the malaria epidemic situation and characteristics in Jiangsu Province in 2017, so as to provide the evidence for formulating the targeted strategy of malaria elimination.

Methods: The data of malaria cases in Jiangsu Province in 2016 were collected from China's Routine Diseases Surveillance Information System (CRDSIS).

Results: Totally, 239 imported malaria cases were reported in Jiangsu Province in 2017, and the cases decreased by 22.

[Results analysis of Jiangsu Provincial Malaria Diagnostic Reference Laboratory in 2017].

Objective: To analyze the results of samples testing of Jiangsu Provincial Malaria Diagnostic Reference Laboratory in 2017, so as to provide the evidence for improving the malaria diagnostic performance in this province.

Methods: The samples of reported malaria cases in Jiangsu were collected by the provincial reference laboratory (PRL) in 2017. The microscopy and nucleic acid test were performed to confirm the infection of species of each case, while antigen tests (rapid diagnostic test, RDT) were performed as well.

HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling.

High mobility group box 1 (HMGB1), a critical nonclassical inflammatory cytokine, has been found up-regulated in patients with idiopathic pulmonary arterial hypertension (IPAH), but its role in vascular remodeling of pulmonary hypertension (PH) is still unknown. In present study, we demonstrated that the plasma level of inflammatory cytokine including HMGB1, interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were elevated in hypoxia-induced pulmonary hypertension rats model. Moreover, expressions of HMGB1 and Toll like receptor-4 (TLR4) in pulmonary arteries were obviously up-regulated accompanied with down-regulation of bone morphogenetic protein receptor 2 (BMPR2) signaling, characterized by decline of phosphorylated Smad1/5/8 (p-Smsd1/5/8) and inhibitor of differention 1 (Id1) expression.

[Construction and application of malaria biobank].

Objective: To establish a systemized malaria biobank with well-rounded epidemiologic data and a computer-aid management system, thus to provide qualified sources for malaria elimination and human malaria research.

Methods: The malaria biobank was based on the platform of Jiangsu Institute of Parasitic Diseases. The blood smear samples, dried blood samples, whole blood samples and parasite strains isolated from patients (from both local and imported cases) were collected since 2011 according to a standardized operational procedure.

[Investigation on malaria rapid diagnostic testing (RDT) - related knowledge, attitude and practice in primary healthcare professionals of Jiangsu Province].

Objective: To investigate the malaria rapid diagnostic testing (RDT) - related knowledge, attitude, practice (KAP) of primary healthcare professionals in Jiangsu Province and analyze the corresponding influencing factors.

Methods: Four cities in Jiangsu Province were selected as the study sites by the typical sampling method to conduct a survey for the RDT related KAP and work satisfaction of primary healthcare professionals, and the multiple logistic regression model was used to explore the relevant influencing factors.

Results: Totally 1 150 questionnaires were issued and 949 valid questionnaires were collected with the recovery rate of 82.

[Analysis of blood smear examination results of fever patients in Jiangsu Province from 2010 to 2016].

Objective: To analyze the working conditions and evaluate the effectiveness of blood smear examinations in fever patients after the start of national malaria elimination program (NMEP), and explore the suitable strategy for malaria diagnosis and surveillance in NMEP, so as to provide the evidence for the development and adaptation of malaria elimination strategies and measures in Jiangsu Province.

Methods: The data of malaria epidemic situation reported by network, fever patients' blood test tables, and epidemiological surveys of malaria cases were collected and statistically analyzed by SPSS 16.0 in Jiangsu Province from 2010 to 2016.

[Progress of malaria elimination of Jiangsu Province, China].

There were vivax malaria, falciparum malaria, and malariae malaria epidemic in Jiangsu Province, and vivax malaria was the dominant disease. and were malaria-transmitted vectors. Since the founding of People's Republic of China, there have been two major malaria outbreaks in Jiangsu Province, when the highest annual malaria incidence reached up to 24.

[Study on expression characteristics of cytochrome P450 genes in ].

Objective: To explore the expression characteristics of cytochrome P450 (CYP) candidate genes (CYP6M3, CYP6Y1, CYP6P5, CYP4H14, CYP4G17, CYP12F16) in .

Methods: The samples were collected from different developmental stages (eggs, larvae, pupae and adult mosquitoes (females and males) ), and different tissues (salivary glands, malpighian tubes, midguts, ovaries, and fat bodies) of and the female adult mosquitoes exposed by different insecticide doses (0, 1.25, 3.

[Protective effect of Dendrobium candidum on isoproterenol induced cardiac hypertrophy in rats].

To study the effect and mechanism of Dendrobium candidum on isoproterenol-induced myocardial hypertrophy in rats, 60 healthy SD rats(30 males and 30 females) were randomly divided into 5 groups(12 in each group): normal group, model group, three D. candidum preventive administration groups(0.09, 0.

[Epidemiological analysis of malaria prevalence in Jiangsu Province in 2016].

Objective: To understand the malaria epidemic situation and characteristics in Jiangsu Province in 2016, so as to provide the evidence for formulating and adjusting the strategy and measures for malaria elimination.

Methods: The data of malaria cases in Jiangsu Province in 2016 were collected from China's Routine Diseases Surveillance Information System (CRD-SIS) and analyzed statistically.

Results: Totally, 308 malaria cases were reported in Jiangsu Province in 2016, and the cases decreased by 23.

Mucilaginibacter rubeus sp. nov., isolated from rhizosphere soil.

A Gram-stain-negative, aerobic, non-motile, rod-shaped and non-spore-forming bacterium, designated EF23T, was isolated from rhizosphere soil of watermelon. Growth of strain EF23T was observed at 10-37 °C, at pH 5.0-9.

Establishment of a Novel Mouse Model of Coronary Microembolization.

Background: Coronary microembolization (CME) has been frequently seen in acute coronary syndromes and percutaneous coronary intervention. Small animal models are required for further studies of CME related to severe prognosis. This study aimed to explore a new mouse model of CME.