Publications by authors named "Yuan-Yan Li"
Mumefural (MF), the primary functional ingredient of prunus mume extract that enhances blood fluidity, is produced by boiling the prunus mume juice for 24-48 h in a traditional one-step concentration process. Low MF yields and long processing time are two disadvantages of this process. This study introduced microwaves into the traditional one-step concentration process of prunus mume extract for increasing MF content.
View Article and Find Full Text PDFGlioblastoma (GBM) is the most aggressive brain tumor, with high mortality. Timosaponin AIII (TIA), a steroidal saponin isolated from the medicinal plant Bge., has been shown to possess anticancer properties in various cancer types.
View Article and Find Full Text PDFArticle Synopsis
- An indigenously developed electronic medication monitor (EMM) was implemented in 138 counties in China and showed a slight increase in tuberculosis (TB) treatment success rates after its introduction.
- A study analyzing TB cases from April 2017 to June 2019 found that a 10% increase in EMM coverage was associated with a 0.2% rise in treatment success rates, though higher proportions of elderly or bacteriologically confirmed cases negatively impacted outcomes.
- The findings indicate a statistically significant relationship between EMM coverage and treatment success, suggesting that more research is necessary to fully understand its effects on TB management.
MiR-26a-5p Inhibits Cell Proliferation and Enhances Doxorubicin Sensitivity in HCC Cells via Targeting AURKA.
Technol Cancer Res Treat
January 2019
Objective: To investigate the role of miR-26a-5p in cell proliferation and doxorubicin sensitivity in hepatocellular carcinoma.
Methods: We evaluated miR-26a-5p expression in hepatocellular carcinoma tissues and cell lines by reverse transcription polymerase chain reaction. Cell Counting Kit-8 was used to examine cell proliferation.
The present study investigated the expression and potential influence of SHC SH2 domain‑binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell proliferation and cell cycle progression, but its role in GC remains unclear. The TCGA database revealed that SHCBP1 is highly expressed in GC tissues.
View Article and Find Full Text PDFBackground: Cyclophilin A (CyPA) is a potential mediator of inflammation. We assessed the predictive value of the first-trimester maternal serum CyPA concentrations for complicated pregnancy.
Methods: The first-trimester serum CyPA concentrations were quantified in 100 women with normal pregnancy and in 351 women with complicated pregnancy, including 102 pre-eclampsia women, 131 gestational hypertension (GH) women and 118 gestational diabetes mellitus (GDM) women.
We measured anti-nociceptive activity of prim-o-glucosylcimifugin (POG), a molecule from Saposhnikovia divaricate (Turcz) Schischk. Anti-nociceptive or anti-inflammatory effects of POG on a formalin-induced tonic nociceptive response and a complete Freund's adjuvant (CFA) inoculation-induced rat arthritis pain model were studied. Single subcutaneous injections of POG produced potent anti-nociception in both models that was comparable to indomethacin analgesia.
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- Spinal cord injury (SCI) leads to significant motor and sensory function loss, drastically affecting the quality of life, and this study explores the effects of RAGE deficiency on recovery in a mouse model of SCI.
- The research found that RAGE expression increased after SCI, and mice lacking RAGE showed improved locomotor recovery, reduced tissue damage, and less inflammation following injury.
- RAGE deficiency was linked to decreased apoptosis and oxidative stress, leading to a reduced glial scar formation at the injury site, highlighting RAGE as a potential therapeutic target for enhancing recovery from SCI.
[Study of an adherence rating score system for tuberculosis patients in China].
Beijing Da Xue Xue Bao Yi Xue Ban
June 2010
Objective: To develop an adherence rating score (ARS) system specific for tuberculosis (TB) patients.
Methods: A cross-sectional survey of 124 TB patients was conducted to figure out risk factors for adherence to treatment. The step-wise logistic regression models were used for selecting adherence-related variables.
Background: More than 1 million tuberculosis (TB) patients are receiving the standard anti-TB treatment provided by China National Tuberculosis Prevention and Control Scheme (CNTS) in China every year. Adverse reactions (ADRs) induced by anti-TB drugs could both do harm to patients and lead to anti-TB treatment failure. The ADACS aimed to explore ADRs' incidences, prognoses, economical and public health impacts for TB patients and TB control, and build a DNA bank of TB patients.
View Article and Find Full Text PDFObjective: To investigate the distribution of glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) genes polymorphisms in Chinese population and smear-positive pulmonary tuberculosis cases of Jilin province.
Methods: Articles about GSTM1 and GSTT1 genes polymorphisms published before 2009 in China were searched. The study population was obtained from fourteen counties (or districts) of Jilin province, which included all cases from November, 2007 to May, 2008, totally 1120.